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boceprevir  (MedChemExpress)


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    Structured Review

    MedChemExpress boceprevir
    (a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) <t>boceprevir,</t> and (g) ebselen. The red dashed lines indicate the heterodimers.
    Boceprevir, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 29 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/boceprevir/Boceprevir/bio_rxiv__2025__11__16__688752-171-2-11
    Average 94 stars, based on 29 article reviews
    boceprevir - by Bioz Stars, 2026-09
    94/100 stars

    Images

    1) Product Images from "Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen"

    Article Title: Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    Journal: bioRxiv

    doi: 10.1101/2025.11.16.688752

    (a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) boceprevir, and (g) ebselen. The red dashed lines indicate the heterodimers.
    Figure Legend Snippet: (a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) boceprevir, and (g) ebselen. The red dashed lines indicate the heterodimers.

    Techniques Used: Mass Spectrometry

    Related Articles

    Mass Spectrometry:

    Article Title: Oleuropein aglycone aldehyde as a SARS-CoV-2 main protease inhibitor.
    Article Snippet: e following, which were obtained commercially: Oleuroside (Cat. No. SYN116383314, SY Innovation, Pyeongtaek, South Korea); Oleuropeinic Acid (Cat. No. HY-N6875) and Boceprevir (Cat. No. HY-10237) from MedChemExpress (Monmouth Junction, NJ, USA); Oleuropeic Acid (Cat. No. RS889155, Interpharm, Goyang, South Korea); Oleuropein Aglycone Aldehyde (Cat. No. O532945) and Elenolic Acid (Cat. No. E501030)

    Article Title: Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen
    Article Snippet: PF-07321332, PF-00835231, boceprevir, carmofur, ebselen, AT7519, and pelitinib were purchased from MedChemExpress (Princeton, NJ, USA).. GC376 was purchased from Selleckchem (Houston, USA).GC376 was purchased from Selleckchem (Houston, USA).

    Article Title: A split luciferase system for studying coronavirus M pro dimerization in vitro and in living cells.
    Article Snippet: Mpro inhibitors were purchased as powders and 381 dissolved in DMSO at working concentrations of 10 mM.Mpro inhibitors were purchased as powders and 381 dissolved in DMSO at working concentrations of 10 mM.. Nirmatrelvir (33), boceprevir (46), 382 GC376 (34), WU-04 (38), and N3 (19) were obtained from MedChemExpress (catalog no. 383 HY138687, HY10237, HY100721, HY149535, and HY136149, respectively).. CDD-1829 and 384 FB2001 were reported (36,47) and provided as fresh powders by Rayhan Biswas and Daniel Harki 385 (University of Minnesota).CDD-1829 and 384 FB2001 were reported (36,47) and provided as fresh powders by Rayhan Biswas and Daniel Harki 385 (University of Minnesota).

    Article Title: Novel SARS-CoV-2 allosteric inhibitors that destabilize the Main Protease M pro dimer.
    Article Snippet: Compounds 1-10 were purchased from Specs, while boceprevir, pelitinib, and nirmatrelvir were purchased from Merck and MedChemExpress, respectively. .. G

    Article Title: Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease
    Article Snippet: Boc-Leu-OH and 4-methoxyindole carboxylic acid were purchased from Ambeed.com at purity grades >95% and checked for identify prior to synthesis. .. Nirmatrelvir and Boceprevir were obtained from Medchemexpress.com. .. Commercially available ACS grade solvents (>99.0% purity) were used for column chromatography without any further purification.

    Article Title: Synthetic notch receptor protein for modulating gene expression
    Article Snippet: mCherry reporter (Addgene #64128) and sgRNA1 Tet-inducible Luciferase plasmids (Addgene #64128) were gifts from Moritoshi Sato (University of Tokyo). .. NS3 Inhibitors Asunaprevir, boceprevir, danoprevir, MK-5172 (a.k.a., grazoprevir), and simeprevir were from MedChemExpress. .. Telaprevir was from Selleck Chemicals.

    Generated:

    Article Title: Oleuropein aglycone aldehyde as a SARS-CoV-2 main protease inhibitor.
    Article Snippet: e following, which were obtained commercially: Oleuroside (Cat. No. SYN116383314, SY Innovation, Pyeongtaek, South Korea); Oleuropeinic Acid (Cat. No. HY-N6875) and Boceprevir (Cat. No. HY-10237) from MedChemExpress (Monmouth Junction, NJ, USA); Oleuropeic Acid (Cat. No. RS889155, Interpharm, Goyang, South Korea); Oleuropein Aglycone Aldehyde (Cat. No. O532945) and Elenolic Acid (Cat. No. E501030)

    Article Title: Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen
    Article Snippet: PF-07321332, PF-00835231, boceprevir, carmofur, ebselen, AT7519, and pelitinib were purchased from MedChemExpress (Princeton, NJ, USA).. GC376 was purchased from Selleckchem (Houston, USA).GC376 was purchased from Selleckchem (Houston, USA).

    Article Title: A split luciferase system for studying coronavirus M pro dimerization in vitro and in living cells.
    Article Snippet: Mpro inhibitors were purchased as powders and 381 dissolved in DMSO at working concentrations of 10 mM.Mpro inhibitors were purchased as powders and 381 dissolved in DMSO at working concentrations of 10 mM.. Nirmatrelvir (33), boceprevir (46), 382 GC376 (34), WU-04 (38), and N3 (19) were obtained from MedChemExpress (catalog no. 383 HY138687, HY10237, HY100721, HY149535, and HY136149, respectively).. CDD-1829 and 384 FB2001 were reported (36,47) and provided as fresh powders by Rayhan Biswas and Daniel Harki 385 (University of Minnesota).CDD-1829 and 384 FB2001 were reported (36,47) and provided as fresh powders by Rayhan Biswas and Daniel Harki 385 (University of Minnesota).

    Article Title: Novel SARS-CoV-2 allosteric inhibitors that destabilize the Main Protease M pro dimer.
    Article Snippet: Compounds 1-10 were purchased from Specs, while boceprevir, pelitinib, and nirmatrelvir were purchased from Merck and MedChemExpress, respectively. .. G

    Article Title: Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease
    Article Snippet: Boc-Leu-OH and 4-methoxyindole carboxylic acid were purchased from Ambeed.com at purity grades >95% and checked for identify prior to synthesis. .. Nirmatrelvir and Boceprevir were obtained from Medchemexpress.com. .. Commercially available ACS grade solvents (>99.0% purity) were used for column chromatography without any further purification.

    Article Title: Synthetic notch receptor protein for modulating gene expression
    Article Snippet: mCherry reporter (Addgene #64128) and sgRNA1 Tet-inducible Luciferase plasmids (Addgene #64128) were gifts from Moritoshi Sato (University of Tokyo). .. NS3 Inhibitors Asunaprevir, boceprevir, danoprevir, MK-5172 (a.k.a., grazoprevir), and simeprevir were from MedChemExpress. .. Telaprevir was from Selleck Chemicals.

    Staining:

    Article Title: Oleuropein aglycone aldehyde as a SARS-CoV-2 main protease inhibitor.
    Article Snippet: e following, which were obtained commercially: Oleuroside (Cat. No. SYN116383314, SY Innovation, Pyeongtaek, South Korea); Oleuropeinic Acid (Cat. No. HY-N6875) and Boceprevir (Cat. No. HY-10237) from MedChemExpress (Monmouth Junction, NJ, USA); Oleuropeic Acid (Cat. No. RS889155, Interpharm, Goyang, South Korea); Oleuropein Aglycone Aldehyde (Cat. No. O532945) and Elenolic Acid (Cat. No. E501030)

    Article Title: Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen
    Article Snippet: PF-07321332, PF-00835231, boceprevir, carmofur, ebselen, AT7519, and pelitinib were purchased from MedChemExpress (Princeton, NJ, USA).. GC376 was purchased from Selleckchem (Houston, USA).GC376 was purchased from Selleckchem (Houston, USA).

    Article Title: A split luciferase system for studying coronavirus M pro dimerization in vitro and in living cells.
    Article Snippet: Mpro inhibitors were purchased as powders and 381 dissolved in DMSO at working concentrations of 10 mM.Mpro inhibitors were purchased as powders and 381 dissolved in DMSO at working concentrations of 10 mM.. Nirmatrelvir (33), boceprevir (46), 382 GC376 (34), WU-04 (38), and N3 (19) were obtained from MedChemExpress (catalog no. 383 HY138687, HY10237, HY100721, HY149535, and HY136149, respectively).. CDD-1829 and 384 FB2001 were reported (36,47) and provided as fresh powders by Rayhan Biswas and Daniel Harki 385 (University of Minnesota).CDD-1829 and 384 FB2001 were reported (36,47) and provided as fresh powders by Rayhan Biswas and Daniel Harki 385 (University of Minnesota).

    Article Title: Novel SARS-CoV-2 allosteric inhibitors that destabilize the Main Protease M pro dimer.
    Article Snippet: Compounds 1-10 were purchased from Specs, while boceprevir, pelitinib, and nirmatrelvir were purchased from Merck and MedChemExpress, respectively. .. G

    Article Title: Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease
    Article Snippet: Boc-Leu-OH and 4-methoxyindole carboxylic acid were purchased from Ambeed.com at purity grades >95% and checked for identify prior to synthesis. .. Nirmatrelvir and Boceprevir were obtained from Medchemexpress.com. .. Commercially available ACS grade solvents (>99.0% purity) were used for column chromatography without any further purification.

    Article Title: Synthetic notch receptor protein for modulating gene expression
    Article Snippet: mCherry reporter (Addgene #64128) and sgRNA1 Tet-inducible Luciferase plasmids (Addgene #64128) were gifts from Moritoshi Sato (University of Tokyo). .. NS3 Inhibitors Asunaprevir, boceprevir, danoprevir, MK-5172 (a.k.a., grazoprevir), and simeprevir were from MedChemExpress. .. Telaprevir was from Selleck Chemicals.

    Produced:

    Article Title: Oleuropein aglycone aldehyde as a SARS-CoV-2 main protease inhibitor.
    Article Snippet: e following, which were obtained commercially: Oleuroside (Cat. No. SYN116383314, SY Innovation, Pyeongtaek, South Korea); Oleuropeinic Acid (Cat. No. HY-N6875) and Boceprevir (Cat. No. HY-10237) from MedChemExpress (Monmouth Junction, NJ, USA); Oleuropeic Acid (Cat. No. RS889155, Interpharm, Goyang, South Korea); Oleuropein Aglycone Aldehyde (Cat. No. O532945) and Elenolic Acid (Cat. No. E501030)

    Article Title: Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen
    Article Snippet: PF-07321332, PF-00835231, boceprevir, carmofur, ebselen, AT7519, and pelitinib were purchased from MedChemExpress (Princeton, NJ, USA).. GC376 was purchased from Selleckchem (Houston, USA).GC376 was purchased from Selleckchem (Houston, USA).

    Article Title: A split luciferase system for studying coronavirus M pro dimerization in vitro and in living cells.
    Article Snippet: Mpro inhibitors were purchased as powders and 381 dissolved in DMSO at working concentrations of 10 mM.Mpro inhibitors were purchased as powders and 381 dissolved in DMSO at working concentrations of 10 mM.. Nirmatrelvir (33), boceprevir (46), 382 GC376 (34), WU-04 (38), and N3 (19) were obtained from MedChemExpress (catalog no. 383 HY138687, HY10237, HY100721, HY149535, and HY136149, respectively).. CDD-1829 and 384 FB2001 were reported (36,47) and provided as fresh powders by Rayhan Biswas and Daniel Harki 385 (University of Minnesota).CDD-1829 and 384 FB2001 were reported (36,47) and provided as fresh powders by Rayhan Biswas and Daniel Harki 385 (University of Minnesota).

    Article Title: Novel SARS-CoV-2 allosteric inhibitors that destabilize the Main Protease M pro dimer.
    Article Snippet: Compounds 1-10 were purchased from Specs, while boceprevir, pelitinib, and nirmatrelvir were purchased from Merck and MedChemExpress, respectively. .. G

    Article Title: Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease
    Article Snippet: Boc-Leu-OH and 4-methoxyindole carboxylic acid were purchased from Ambeed.com at purity grades >95% and checked for identify prior to synthesis. .. Nirmatrelvir and Boceprevir were obtained from Medchemexpress.com. .. Commercially available ACS grade solvents (>99.0% purity) were used for column chromatography without any further purification.

    Article Title: Synthetic notch receptor protein for modulating gene expression
    Article Snippet: mCherry reporter (Addgene #64128) and sgRNA1 Tet-inducible Luciferase plasmids (Addgene #64128) were gifts from Moritoshi Sato (University of Tokyo). .. NS3 Inhibitors Asunaprevir, boceprevir, danoprevir, MK-5172 (a.k.a., grazoprevir), and simeprevir were from MedChemExpress. .. Telaprevir was from Selleck Chemicals.



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    Image Search Results


    (a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) boceprevir, and (g) ebselen. The red dashed lines indicate the heterodimers.

    Journal: bioRxiv

    Article Title: Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    doi: 10.1101/2025.11.16.688752

    Figure Lengend Snippet: (a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) boceprevir, and (g) ebselen. The red dashed lines indicate the heterodimers.

    Article Snippet: PF-07321332, PF-00835231, boceprevir, carmofur, ebselen, AT7519, and pelitinib were purchased from MedChemExpress (Princeton, NJ, USA).

    Techniques: Mass Spectrometry