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BOC Sciences
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Image Search Results
Journal: PLoS ONE
Article Title: Conditional Inducible Triple-Transgenic Mouse Model for Rapid Real-Time Detection of HCV NS3/4A Protease Activity
doi: 10.1371/journal.pone.0150894
Figure Lengend Snippet: (A) Two groups of triple-transgenic mice (n = 5 per group) were treated with telaprevir (200 mg/kg) or DMSO via oral gavage twice daily for 10 days. During the treatment period, the mice were continuously induced with Dox (1 mg/mL Dox and 50 g/L sugar were dissolved in their drinking water). (B) Triple-transgenic mice were induced with Dox for 10 days (n = 5 per group). At the third day after Dox induction, the mice were treated with boceprevir (100 mg/kg) or DMSO via oral gavage twice daily for 7 days. Blood samples were collected daily from the caudal vein to measure plasma Gluc activity. Each data point represents the mean ± SD. *** = p<0.001 compared with the vehicle control.
Article Snippet: Telaprevir and
Techniques: Transgenic Assay, Clinical Proteomics, Activity Assay, Control
Journal: Journal of medicinal chemistry
Article Title: Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle
doi: 10.1021/acs.jmedchem.7b00561
Figure Lengend Snippet: Synergistic Activity of 7a and 7ii with Selected HCV Therapeutics
Article Snippet: 13 , 22 The known antiviral drugs include ribavirin (Sigma-Aldrich), sofosbuvir (Advanced Chemblocks), telaprevir (Selleckchem), daclatasvir (Selleckchem), cyclosporin A (Sigma-Aldrich), and
Techniques: Activity Assay