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(a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) <t>boceprevir,</t> and (g) ebselen. The red dashed lines indicate the heterodimers.
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boceprevir  (Merck & Co)
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(a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) <t>boceprevir,</t> and (g) ebselen. The red dashed lines indicate the heterodimers.
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biktarvy boceprevir victrelis cidofovir cobicistat cidofovir cobicistat tybost combivir daclatasvir  (Gilead Sciences)
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(a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) <t>boceprevir,</t> and (g) ebselen. The red dashed lines indicate the heterodimers.
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reference ligand boceprevir  (Molecular Dynamics Inc)
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(a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) <t>boceprevir,</t> and (g) ebselen. The red dashed lines indicate the heterodimers.
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merck s boceprevir  (Merck & Co)
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Merck & Co merck s boceprevir
(a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) <t>boceprevir,</t> and (g) ebselen. The red dashed lines indicate the heterodimers.
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(a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) boceprevir, and (g) ebselen. The red dashed lines indicate the heterodimers.

Journal: bioRxiv

Article Title: Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

doi: 10.1101/2025.11.16.688752

Figure Lengend Snippet: (a) The strategy for M pro subunit exchange. (b) Monitoring of unbound M pro subunit exchange by native mass spectrometry. M pro subunit exchange is affected by (c) PF-07321332, (d) PF-00835231, (e) GC376, (f) boceprevir, and (g) ebselen. The red dashed lines indicate the heterodimers.

Article Snippet: PF-07321332, PF-00835231, boceprevir, carmofur, ebselen, AT7519, and pelitinib were purchased from MedChemExpress (Princeton, NJ, USA).

Techniques: Mass Spectrometry