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cell motility hitkit  (Thermo Fisher)


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    Thermo Fisher cell motility hitkit
    Cell Motility Hitkit, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hitkit/us09062341-13-21-24
    Average 90 stars, based on 1 article reviews
    cell motility hitkit - by Bioz Stars, 2026-11
    90/100 stars

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    Related Articles

    other:

    Article Title: Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor
    Article Snippet: Cells were also labeled with rhodamine phalloidin and DAPI (Molecular Probes).

    Article Title: Abl functions as a negative regulator of Met-induced cell motility via phosphorylation of the adapter protein CrkII.
    Article Snippet: HGF, the ligand for the Met receptor tyrosine kinase, is a potent modulator of epithelial–mesenchymal transition and dispersal of epithelial cells, which are processes that play a crucial role in cell motility during normal development and malignant transformation.. We and others have shown earlier that the adapter protein CrkII and its associated proteins positively regulate cell migratory events in response to both haptotactic and chemotactic stimuli, including HGF.. Here, we demonstrate for the first time that phosphorylation of CrkII serves as a negative feedback loop to regulate motile responses upon Met stimulation.

    Multiple Displacement Amplification:

    Article Title: The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
    Article Snippet: .. Cell MotilityAssay Motility was measured in MDA-MB-231 breast cancer cells treated with PX-866 or wortmannin according to the Cellomics Cell Motility HitKit manufacturer’s protocol. .. Briefly, fluorescent microspheres were coated onto collagen-covered 96-well plates (BD Biosciences).

    Motility Assay:

    Article Title: Actin-depolymerizing Factor and Cofilin-1 Play Overlapping Roles in Promoting Rapid F-Actin Depolymerization in Mammalian Nonmuscle Cells
    Article Snippet: Transfection of B16F1 cells was performed with Superfect (QIAGEN, Valencia, CA) and for NIH3T3 cells with FuGENE6 (Roche Diagnostics, Mannheim, Germany) according to manufacturers' recommendations. .. Cell Motility Assays Cell motility assay with NIH 3T3 cells was performed with the Cell Motility HitKit (Cellomics, Pittsburgh, PA). ..

    Article Title: The EphB4 Receptor-tyrosine Kinase Promotes the Migration of Melanoma Cells through Rho-mediated Actin Cytoskeleton Reorganization
    Article Snippet: .. Single Cell Motility Assay—The single cell motility assay was performed with Cell Motility Hitkit (Cellomics). ..

    Migration:

    Article Title: Substrate used for cell migration assays and method for cell migration assays
    Article Snippet: .. Examples of commercially available apparatuses used for cell migration assays include classic Boyden's chambers, cell culture inserts, FluoroBlock® (BD Biosciences), and Cell Motility HitKit® (Cellomics). ..

    Cell Culture:

    Article Title: Substrate used for cell migration assays and method for cell migration assays
    Article Snippet: .. Examples of commercially available apparatuses used for cell migration assays include classic Boyden's chambers, cell culture inserts, FluoroBlock® (BD Biosciences), and Cell Motility HitKit® (Cellomics). ..

    Single Cell:

    Article Title: The EphB4 Receptor-tyrosine Kinase Promotes the Migration of Melanoma Cells through Rho-mediated Actin Cytoskeleton Reorganization
    Article Snippet: .. Single Cell Motility Assay—The single cell motility assay was performed with Cell Motility Hitkit (Cellomics). ..



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    Image Search Results


    The effects of TXS inhibition on tumour cell apoptosis . A) Apoptosis was induced in a dose-dependant manner following 24 h treatment with ozagrel, relative to untreated control cells. Cell health following ozagrel treatment was assessed using 3 spectrally distinct flourophores to examine nuclei, f -actin (marker of cytoskeletal integrity), and mitochondrial mass/potential. Reduced f -actin levels demonstrate a loss in cellular integrity during apoptosis. Membrane blebbing also occurs and mitochondrial activity occurs, coupled with a loss of potential across the mitochondrial membrane. These markers were quantified by the Kinetic Scan HCS reader and are represented (B). Similar observations were made in SKMES-1 cells (data not shown). Apoptosis was confirmed following selective TXS inhibition by Cell Death Detection ELISA and DNA laddering in both cell lines (A-549 shown as representative). Cell Death ELISA demonstrated increased apoptosis in a concentration dependant manner, with fold induction expressed as a ratio of control cells (C). DNA laddering was also observed following ozagrel treatment at both 500 nM and 5 μM concentrations (D).

    Journal: Molecular Cancer

    Article Title: Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer

    doi: 10.1186/1476-4598-10-25

    Figure Lengend Snippet: The effects of TXS inhibition on tumour cell apoptosis . A) Apoptosis was induced in a dose-dependant manner following 24 h treatment with ozagrel, relative to untreated control cells. Cell health following ozagrel treatment was assessed using 3 spectrally distinct flourophores to examine nuclei, f -actin (marker of cytoskeletal integrity), and mitochondrial mass/potential. Reduced f -actin levels demonstrate a loss in cellular integrity during apoptosis. Membrane blebbing also occurs and mitochondrial activity occurs, coupled with a loss of potential across the mitochondrial membrane. These markers were quantified by the Kinetic Scan HCS reader and are represented (B). Similar observations were made in SKMES-1 cells (data not shown). Apoptosis was confirmed following selective TXS inhibition by Cell Death Detection ELISA and DNA laddering in both cell lines (A-549 shown as representative). Cell Death ELISA demonstrated increased apoptosis in a concentration dependant manner, with fold induction expressed as a ratio of control cells (C). DNA laddering was also observed following ozagrel treatment at both 500 nM and 5 μM concentrations (D).

    Article Snippet: The Multiparamater Apoptosis HitKit from Cellomics provides High Content Screening qualified fluorescent reagents for simultaneous measurement of 3 fundamental parameters of apoptosis.

    Techniques: Inhibition, Marker, Activity Assay, Enzyme-linked Immunosorbent Assay, DNA Laddering, Concentration Assay

    Effect of stable TXS -over-expression on tumour cell survival . Apoptosis was measured in TXS stable transfectants, and corresponding controls (wild-type and empty vector) following 48 h (A) and 72 h (B) serum-starvation by flow cytometry. Representative dot plots following 72 h serum starvation are shown for wild-type (C), empty vector (D) and TXS overexpressing (E) cells. Graphical data is represented at a percentage of the empty vector control, which was set to 100%. Data is expressed as mean ± SEM. n=3 independent experiments.

    Journal: Molecular Cancer

    Article Title: Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer

    doi: 10.1186/1476-4598-10-25

    Figure Lengend Snippet: Effect of stable TXS -over-expression on tumour cell survival . Apoptosis was measured in TXS stable transfectants, and corresponding controls (wild-type and empty vector) following 48 h (A) and 72 h (B) serum-starvation by flow cytometry. Representative dot plots following 72 h serum starvation are shown for wild-type (C), empty vector (D) and TXS overexpressing (E) cells. Graphical data is represented at a percentage of the empty vector control, which was set to 100%. Data is expressed as mean ± SEM. n=3 independent experiments.

    Article Snippet: The Multiparamater Apoptosis HitKit from Cellomics provides High Content Screening qualified fluorescent reagents for simultaneous measurement of 3 fundamental parameters of apoptosis.

    Techniques: Over Expression, Plasmid Preparation, Flow Cytometry