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triapine  (MedChemExpress)


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    MedChemExpress triapine
    Triapine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/triapine/product/MedChemExpress
    Average 94 stars, based on 10 article reviews
    triapine - by Bioz Stars, 2026-02
    94/100 stars

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    Fig. 1 RNRi and WEE1i cooperate in inducing cell death in ES cells. Cells were exposed to triapine in combination with (A) adavosertib or (B) ZN-c3 for 48 h. Cell death was determined by flow-cytometric analysis of PI uptake. Means ± SEM of each three independent measurements are shown

    Journal: BMC cancer

    Article Title: Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing's sarcoma cells.

    doi: 10.1186/s12885-025-13691-2

    Figure Lengend Snippet: Fig. 1 RNRi and WEE1i cooperate in inducing cell death in ES cells. Cells were exposed to triapine in combination with (A) adavosertib or (B) ZN-c3 for 48 h. Cell death was determined by flow-cytometric analysis of PI uptake. Means ± SEM of each three independent measurements are shown

    Article Snippet: Twenty-four hours after seeding, cells were treated with triapine (0.125–1 μM; Selleck Chemicals, Planegg, Germany), adavosertib (0.05–0.5 μM; Selleck Chemicals), ZN-c3 (0.3–0.5 μM; Selleck Chemicals), olaparib (0.1–2 μM; Biomol, Hamburg, Germany) and/or veliparib (2.5–20 μM; Biomol) and incubated for 24 h (caspase 3/7 activity, immunoblotting, PCR) or 48 h (flow-cytometric analyses).

    Techniques:

    Fig. 2 CI values for triapine plus adavosertib or ZN-c3 in ES cells. Based on data from (A) Fig. 1A and (B) Fig. 1B, CI values were calculated with the Chou- Talalay method

    Journal: BMC cancer

    Article Title: Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing's sarcoma cells.

    doi: 10.1186/s12885-025-13691-2

    Figure Lengend Snippet: Fig. 2 CI values for triapine plus adavosertib or ZN-c3 in ES cells. Based on data from (A) Fig. 1A and (B) Fig. 1B, CI values were calculated with the Chou- Talalay method

    Article Snippet: Twenty-four hours after seeding, cells were treated with triapine (0.125–1 μM; Selleck Chemicals, Planegg, Germany), adavosertib (0.05–0.5 μM; Selleck Chemicals), ZN-c3 (0.3–0.5 μM; Selleck Chemicals), olaparib (0.1–2 μM; Biomol, Hamburg, Germany) and/or veliparib (2.5–20 μM; Biomol) and incubated for 24 h (caspase 3/7 activity, immunoblotting, PCR) or 48 h (flow-cytometric analyses).

    Techniques:

    Fig. 6 RNRi and WEE1i cooperate in inducing p53 target gene expression. Cells were exposed to triapine in combination with adavosertib or ZN-c3 for 24 h. CDKN1A and BBC3 expression levels were determined by real-time RT-PCR and normalised to B2M expression levels; relative gene expression levels are the ratio of treated cells to untreated cells. Means ± SEM of each three independent measurements are shown (*p < 0.05, **p < 0.01, ***p < 0.001)

    Journal: BMC cancer

    Article Title: Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing's sarcoma cells.

    doi: 10.1186/s12885-025-13691-2

    Figure Lengend Snippet: Fig. 6 RNRi and WEE1i cooperate in inducing p53 target gene expression. Cells were exposed to triapine in combination with adavosertib or ZN-c3 for 24 h. CDKN1A and BBC3 expression levels were determined by real-time RT-PCR and normalised to B2M expression levels; relative gene expression levels are the ratio of treated cells to untreated cells. Means ± SEM of each three independent measurements are shown (*p < 0.05, **p < 0.01, ***p < 0.001)

    Article Snippet: Twenty-four hours after seeding, cells were treated with triapine (0.125–1 μM; Selleck Chemicals, Planegg, Germany), adavosertib (0.05–0.5 μM; Selleck Chemicals), ZN-c3 (0.3–0.5 μM; Selleck Chemicals), olaparib (0.1–2 μM; Biomol, Hamburg, Germany) and/or veliparib (2.5–20 μM; Biomol) and incubated for 24 h (caspase 3/7 activity, immunoblotting, PCR) or 48 h (flow-cytometric analyses).

    Techniques: Targeted Gene Expression, Expressing, Quantitative RT-PCR, Gene Expression