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spp1  (OriGene)


Bioz Verified Symbol OriGene is a verified supplier
Bioz Manufacturer Symbol OriGene manufactures this product  
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    Structured Review

    OriGene spp1
    Spp1, supplied by OriGene, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/spp1/Spp1+(NM_009263)+Mouse+Tagged+ORF+Clone/10__1016_slash_j__jpha__2026__101679-138-17-19
    Average 94 stars, based on 1 article reviews
    spp1 - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Transduction:

    Article Title: Intracellular SPP1 inhibits FNDC5 to activate DEGS1-regulated ceramide metabolism in silicosis
    Article Snippet: PLA was performed using Duolink In Situ Detection Reagents Red (Duo92101, SigmaAldrich, St. Louis, MO, USA) following the manufacturer's protocol. .. MH-S cells were subjected to various treatments: exposure to 150 μg/mL crystalline silica, transduction for overexpression of Spp1 (MR226579L4, OriGene Technologies Inc., Rockville, MD, USA), or transduction for overexpression of Fndc5 (G84198, Miaolingbio. ..

    Over Expression:

    Article Title: Intracellular SPP1 inhibits FNDC5 to activate DEGS1-regulated ceramide metabolism in silicosis
    Article Snippet: PLA was performed using Duolink In Situ Detection Reagents Red (Duo92101, SigmaAldrich, St. Louis, MO, USA) following the manufacturer's protocol. .. MH-S cells were subjected to various treatments: exposure to 150 μg/mL crystalline silica, transduction for overexpression of Spp1 (MR226579L4, OriGene Technologies Inc., Rockville, MD, USA), or transduction for overexpression of Fndc5 (G84198, Miaolingbio. ..

    Immunohistochemistry:

    Article Title: Antibacterial and DNA-Based Hydrogels In Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding.
    Article Snippet: Alveolar bone injury under diabetic conditions can severely impede many oral disease treatments.. Rebuilding diabetic alveolar bone in clinics is currently challenging due to persistent infection and inflammatory response.. Here, an antibacterial DNA-based hydrogel named Agantigel is developed by integrating silver nanoclusters (AgNCs) and tumor necrosis factor-alpha (TNF-α) antibody into DNA hydrogel to promote diabetic alveolar bone regeneration.

    Staining:

    Article Title: Antibacterial and DNA-Based Hydrogels In Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding.
    Article Snippet: Alveolar bone injury under diabetic conditions can severely impede many oral disease treatments.. Rebuilding diabetic alveolar bone in clinics is currently challenging due to persistent infection and inflammatory response.. Here, an antibacterial DNA-based hydrogel named Agantigel is developed by integrating silver nanoclusters (AgNCs) and tumor necrosis factor-alpha (TNF-α) antibody into DNA hydrogel to promote diabetic alveolar bone regeneration.

    Incubation:

    Article Title: Antibacterial and DNA-Based Hydrogels In Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding.
    Article Snippet: Alveolar bone injury under diabetic conditions can severely impede many oral disease treatments.. Rebuilding diabetic alveolar bone in clinics is currently challenging due to persistent infection and inflammatory response.. Here, an antibacterial DNA-based hydrogel named Agantigel is developed by integrating silver nanoclusters (AgNCs) and tumor necrosis factor-alpha (TNF-α) antibody into DNA hydrogel to promote diabetic alveolar bone regeneration.



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    Image Search Results


    A Identification of four celltypes in the LLC TME by scRNA-seq. B Anti-SPP1 therapy increases all immune subsets, decreases non-immune cells. C Subclustering of T/NK cells. D GO enrichment analysis of genes highly expressed in CD8 + T cells at different groups (control vs. anti-SPP1). E Anti-SPP1 therapy decreases M2-like macrophage proportion. F Immunofluorescence indicated increased CD8 + T infiltration with concurrent M2 reduction post-treatment.

    Journal: NPJ Precision Oncology

    Article Title: Multi-omics profiling reveals tumor microenvironment characteristics linked to immunotherapy response and prognosis in non-small cell lung cancer

    doi: 10.1038/s41698-026-01474-2

    Figure Lengend Snippet: A Identification of four celltypes in the LLC TME by scRNA-seq. B Anti-SPP1 therapy increases all immune subsets, decreases non-immune cells. C Subclustering of T/NK cells. D GO enrichment analysis of genes highly expressed in CD8 + T cells at different groups (control vs. anti-SPP1). E Anti-SPP1 therapy decreases M2-like macrophage proportion. F Immunofluorescence indicated increased CD8 + T infiltration with concurrent M2 reduction post-treatment.

    Article Snippet: Five days post-inoculation, mice with palpable tumors were randomly assigned to four treatment groups ( n = 4 per group) using a random number table : Control (PBS) , Anti-PD-1 (clone RMP1-14, Bio X Cell, #BE0146) , Anti-SPP1 (anti-mouse osteopontin antibody, clone 103D6, MCE), and Anti-SPP1 combined with Anti-PD-1.

    Techniques: Control, Immunofluorescence