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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of <t>DCT</t> rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .
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Forest plots representing allele (panel A and B) and genotype (panel C) association of DCT rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .

Journal: Biochemistry and Biophysics Reports

Article Title: Functional polymorphisms in pigmentation-related genes MC1R and DCT display population-specific association with wet age-related macular degeneration

doi: 10.1016/j.bbrep.2026.102477

Figure Lengend Snippet: Forest plots representing allele (panel A and B) and genotype (panel C) association of DCT rs1407995 and MC1R rs3212351 variants to wet AMD in the Polish, Hungarian, Finnish and the UK cohorts. Age and sex adjusted odds ratios (OR) with 95 % confidence intervals (CI95), related p -values, and weight (%) of each cohort in the study are shown. Polymorphism specific alleles are shown in .

Article Snippet: Genotyping of Polish and Hungarian cohorts was performed using TaqMan SNP Genotyping Assay ID: C_7593137_20 for variant rs1407995 and Custom Genotyping Assay for rs3212351, both provided by Thermo Fisher Scientific (Foster City, CA, USA).

Techniques:

Known interactions of the MC1R-MITF pathway and DCT depicting critical regulatory loops involved in l -DOPA and melanin synthesis in RPE cells. The recently described associations with cellular antioxidant and immune defense mechanisms, mitochondrial function as well as PEDF-mediated anti-angiogenic actions are also shown. Associated risk variants rs1407995 and rs3212351 are indicated (SNP in red) in the DCT and MC1R genes, respectively.

Journal: Biochemistry and Biophysics Reports

Article Title: Functional polymorphisms in pigmentation-related genes MC1R and DCT display population-specific association with wet age-related macular degeneration

doi: 10.1016/j.bbrep.2026.102477

Figure Lengend Snippet: Known interactions of the MC1R-MITF pathway and DCT depicting critical regulatory loops involved in l -DOPA and melanin synthesis in RPE cells. The recently described associations with cellular antioxidant and immune defense mechanisms, mitochondrial function as well as PEDF-mediated anti-angiogenic actions are also shown. Associated risk variants rs1407995 and rs3212351 are indicated (SNP in red) in the DCT and MC1R genes, respectively.

Article Snippet: Genotyping of Polish and Hungarian cohorts was performed using TaqMan SNP Genotyping Assay ID: C_7593137_20 for variant rs1407995 and Custom Genotyping Assay for rs3212351, both provided by Thermo Fisher Scientific (Foster City, CA, USA).

Techniques: