Journal: Przegla̜d Menopauzalny = Menopause Review

Article Title: The clinicopathological role of miRNA-196a and its SNP variant rs11614913 in high-grade ovarian cancer

doi: 10.5114/pm.2024.145949

Figure Lengend Snippet: Distribution of genotypes and alleles of SNP rs11614913 in test group and controls (in total)

Article Snippet: The miR-196a C/T single-nucleotide polymorphism rs11614913 was analyzed using the commercially available pre-made TaqMan SNP Genotyping Assay (Applied Biosystems, CA, USA) with the assay ID: C_31185852_10.

Techniques: Control

Journal: The New England journal of medicine

Article Title: MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

doi: 10.1056/NEJMoa1801562

Figure Lengend Snippet: Genotypic Association of MUC5B rs35705950 Single-Nucleotide Polymorphism in Patients with RA, with and without ILD, and Unaffected Controls. *

Article Snippet: GENOTYPING Genotyping of the MUC5B rs35705950 single-nucleotide polymorphism involved the use of TaqMan Genotyping Assays (Applied Biosystems), as reported previously.

Techniques:

Journal: The New England journal of medicine

Article Title: MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

doi: 10.1056/NEJMoa1801562

Figure Lengend Snippet: Shown are forest plots of odds ratios and 95% confidence intervals. The boxes indicate odds ratios, and the horizontal lines indicate 95% confidence intervals for the best-fitting genetic model (dominant or additive) for each association test. The black dashed line represents a mean odds ratio value of 1. The red boxes and red lines indicate the overall odds ratios and 95% confidence intervals, respectively. The case series from France represents the discovery population. For comparisons between patients with RA and controls, the associations were adjusted for the country of origin and sex. For comparisons among patients with RA, the associations were adjusted for the country of origin, sex, age at inclusion, and smoking status. Panel A shows a lack of association of the MUC5B promoter variant rs35705950 with RA without ILD. Panel B shows an additive genotypic association of the MUC5B promoter variant rs35705950 with RA-ILD. The red dashed line represents the mean overall odds ratio value. In Panels A and B, United States–1 indicates one of two case series from the United States. Panel C shows a dominant genotypic association of the MUC5B promoter variant rs35705950 with ILD among patients with RA and those with a pattern of usual interstitial pneumonia (UIP) or possible UIP. RA-UIP denotes RA-ILD and a UIP or possible UIP pattern, and RA-nonUIP denotes RA-ILD and a pattern inconsistent with UIP.

Article Snippet: GENOTYPING Genotyping of the MUC5B rs35705950 single-nucleotide polymorphism involved the use of TaqMan Genotyping Assays (Applied Biosystems), as reported previously.

Techniques: Variant Assay

Journal: The New England journal of medicine

Article Title: MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

doi: 10.1056/NEJMoa1801562

Figure Lengend Snippet: Dominant Genotypic Association of MUC5B rs35705950 Single-Nucleotide Polymorphism in Patients with RA-ILD and a Pattern of Usual Interstitial Pneumonia (UIP) or Possible UIP and in Patients with RA-ILD and a Pattern Inconsistent with UIP. *

Article Snippet: GENOTYPING Genotyping of the MUC5B rs35705950 single-nucleotide polymorphism involved the use of TaqMan Genotyping Assays (Applied Biosystems), as reported previously.

Techniques:

Journal: The New England journal of medicine

Article Title: MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

doi: 10.1056/NEJMoa1801562

Figure Lengend Snippet: Shown are representative lung-tissue images from an unaffected control with a GG genotype (Panel A), a patient with RA-ILD and a GG genotype (Panel B), and a patient with RA-ILD and a GT genotype (Panel C). Panel A includes a low-power view (left) of normal lung, top and middle insets with a high-power view of bronchiole with MUC5B staining, and a bottom inset with a high-power view of alveolar epithelia. Panels B and C each include a low-power view (left) of the UIP pattern in explanted lung tissue, a top inset with a high-power view of bronchiole with MUC5B staining, and middle and bottom insets with a high-power view of MUC5B staining in metaplastic epithelia lining honeycomb cysts and MUC5B staining of mucus in honeycomb cysts.

Article Snippet: GENOTYPING Genotyping of the MUC5B rs35705950 single-nucleotide polymorphism involved the use of TaqMan Genotyping Assays (Applied Biosystems), as reported previously.

Techniques: Control, Staining