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snca  (Bioss)


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    Bioss snca
    Snca, supplied by Bioss, used in various techniques. Bioz Stars score: 92/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/snca/product/Bioss
    Average 92 stars, based on 5 article reviews
    snca - by Bioz Stars, 2026-02
    92/100 stars

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    Image Search Results


    ( A ) The schematic shows the culture pipeline for RNA collection and bulk RNA-seq. ( B ) Venn diagram showing the common differentially expressed genes in Sartans and CBE+Sartans conditions. ( C ) GO enriched terms in DMSO vs Sartans. Biological processes like transport, endocytosis, and response to ROS were significantly altered by AGTR1 inhibition. ( D ) Top 20 UP and DOWN-regulated genes in DMSO vs Sartans, showing SNCA and SNCB (red rectangles) as part of the top DOWN-regulated genes and PRDX1 and G6PD (green rectangles) as part of the top UP-regulated genes by AGTR1 inhibition.

    Journal: bioRxiv

    Article Title: Scalable Human Cellular Models of Parkinson’s Disease Reveal A Druggable Link Between the Angiotensin Receptor 1 and α-Synuclein Pathology

    doi: 10.1101/2025.11.18.689137

    Figure Lengend Snippet: ( A ) The schematic shows the culture pipeline for RNA collection and bulk RNA-seq. ( B ) Venn diagram showing the common differentially expressed genes in Sartans and CBE+Sartans conditions. ( C ) GO enriched terms in DMSO vs Sartans. Biological processes like transport, endocytosis, and response to ROS were significantly altered by AGTR1 inhibition. ( D ) Top 20 UP and DOWN-regulated genes in DMSO vs Sartans, showing SNCA and SNCB (red rectangles) as part of the top DOWN-regulated genes and PRDX1 and G6PD (green rectangles) as part of the top UP-regulated genes by AGTR1 inhibition.

    Article Snippet: Primers were ordered from predesigned Taqman PCR assays (Thermofisher) with the following catalog numbers: (GAPDH: Hs02786624_g1; SNCA: Hs00240906_m1; SNCB: Hs01015410_g1; SNCAIP: Hs00917422_m1).

    Techniques: RNA Sequencing, Inhibition

    ( A ) The schematic shows different conditions used for qRT-PCR analysis of synuclein gene expression. ( B-D ) qRT-PCR for SNCA, SNCAIP, and SNCB expression using Ang II (AGTR1 agonist) vs Cand (AGTR1 inhibitor). Significance is shown compared to DMSO and CBE + CAND compared to CBE * p<0.05, **p<0.01. ( E ) Pipeline of survival experiments in 3D mDA-mAstro assembloids. CBE treatment followed by AGTR1 inhibitors (sartans) was performed at D60 for 14 days. ( F, G ) CBE treatment increases the number of mDA neurons that are positive for p129-αSYN, a hallmark of PD. Treatment with Candesartan or Valsartan mitigates the number of p129αSYN positive cells. (mDA-mAstro assembloids from 3 independent differentiations). Significance is shown compared to the CBE condition. **p<0.01, *** p<0.001. Scale bars: 200μm (100μm in zoomed images)

    Journal: bioRxiv

    Article Title: Scalable Human Cellular Models of Parkinson’s Disease Reveal A Druggable Link Between the Angiotensin Receptor 1 and α-Synuclein Pathology

    doi: 10.1101/2025.11.18.689137

    Figure Lengend Snippet: ( A ) The schematic shows different conditions used for qRT-PCR analysis of synuclein gene expression. ( B-D ) qRT-PCR for SNCA, SNCAIP, and SNCB expression using Ang II (AGTR1 agonist) vs Cand (AGTR1 inhibitor). Significance is shown compared to DMSO and CBE + CAND compared to CBE * p<0.05, **p<0.01. ( E ) Pipeline of survival experiments in 3D mDA-mAstro assembloids. CBE treatment followed by AGTR1 inhibitors (sartans) was performed at D60 for 14 days. ( F, G ) CBE treatment increases the number of mDA neurons that are positive for p129-αSYN, a hallmark of PD. Treatment with Candesartan or Valsartan mitigates the number of p129αSYN positive cells. (mDA-mAstro assembloids from 3 independent differentiations). Significance is shown compared to the CBE condition. **p<0.01, *** p<0.001. Scale bars: 200μm (100μm in zoomed images)

    Article Snippet: Primers were ordered from predesigned Taqman PCR assays (Thermofisher) with the following catalog numbers: (GAPDH: Hs02786624_g1; SNCA: Hs00240906_m1; SNCB: Hs01015410_g1; SNCAIP: Hs00917422_m1).

    Techniques: Quantitative RT-PCR, Gene Expression, Expressing

    ( A ) Immunofluorescent labeling of α-Synuclein on D74 mDA-mAstro assembloids from . ( B, C ) Images from the human whole-brain snRNA-seq database and the Human Aged Midbrain database show high expression of SNCA, SNCAIP, and SNCB in neuronal populations and SNpc. However, only SNCA and SNCAIP, and not SNCB, show high expression in Astrocytes and MSN neurons. Scale bars: 200 μm.

    Journal: bioRxiv

    Article Title: Scalable Human Cellular Models of Parkinson’s Disease Reveal A Druggable Link Between the Angiotensin Receptor 1 and α-Synuclein Pathology

    doi: 10.1101/2025.11.18.689137

    Figure Lengend Snippet: ( A ) Immunofluorescent labeling of α-Synuclein on D74 mDA-mAstro assembloids from . ( B, C ) Images from the human whole-brain snRNA-seq database and the Human Aged Midbrain database show high expression of SNCA, SNCAIP, and SNCB in neuronal populations and SNpc. However, only SNCA and SNCAIP, and not SNCB, show high expression in Astrocytes and MSN neurons. Scale bars: 200 μm.

    Article Snippet: Primers were ordered from predesigned Taqman PCR assays (Thermofisher) with the following catalog numbers: (GAPDH: Hs02786624_g1; SNCA: Hs00240906_m1; SNCB: Hs01015410_g1; SNCAIP: Hs00917422_m1).

    Techniques: Labeling, Expressing