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riociguat  (MedChemExpress)


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    Structured Review

    MedChemExpress riociguat
    Riociguat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 19 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/riociguat/Riociguat/pmc13412036-212-23-27
    Average 94 stars, based on 19 article reviews
    riociguat - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Cell Culture:

    Article Title: Mitochondrial Abundant Heat Soluble (MAHS) Protein Expression Modulates Metabolic Dynamics in Human Adipose-Derived Stem Cells
    Article Snippet: .. At 24 h after plating, cells were cultured for 1 h in routine culture media or routine culture media supplemented with 0.1 μM Riociguat (BAY 632521; HY-14779; MedChemExpress, Monmouth Junction, NJ, USA). .. Intracellular cyclic guanosine monophosphate (cGMP) levels were measured using a Cyclic GMP ELISA Kit (581021; Cayman Chemical, Ann Arbor, MI, USA) following the manufacturer’s protocol for acetylated samples.

    Incubation:

    Article Title: Differential modulation of the sGC-cGMP pathway by sGC stimulators and activators in human lung cells.
    Article Snippet: .. When experiments were performed without CSE stimulation, cells were first pre-treated with or without sildenafil 1 μM (Cayman Chemical, Ann Arbor, MI, U.S.) for 15 min, followed by an additional 15-minute incubation with either riociguat (BAY 63-2521; MedChemExpress, Monmouth Junction, NJ, U.S.) or cinaciguat (BAY 58-2667; MedChemExpress, Monmouth Junction, NJ, U.S.). ..

    Biomarker Discovery:

    Article Title: Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice.
    Article Snippet: .. Absolute ethanol was purchased from Panreac Applichem (Spain); riociguat was acquired from Medchem Express (Sollentuna, SWEDEN); protease and phosphatase inhibitor PhosSTOP cocktail tablets were obtained from Roche Diagnosis GmbH (Mannheim, Germany) and Testosterone ELISA kit DE1559 was acquired from Demeditec (Kiel, Germany). .. Ketamine hydrochloride was obtained from Pfizer, S.L. (Alcobendas Spain) and diazepam from Roche Farma, S.A. (Madrid, Spain).

    Enzyme-linked Immunosorbent Assay:

    Article Title: Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice.
    Article Snippet: .. Absolute ethanol was purchased from Panreac Applichem (Spain); riociguat was acquired from Medchem Express (Sollentuna, SWEDEN); protease and phosphatase inhibitor PhosSTOP cocktail tablets were obtained from Roche Diagnosis GmbH (Mannheim, Germany) and Testosterone ELISA kit DE1559 was acquired from Demeditec (Kiel, Germany). .. Ketamine hydrochloride was obtained from Pfizer, S.L. (Alcobendas Spain) and diazepam from Roche Farma, S.A. (Madrid, Spain).



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    Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), <t>riociguat</t> (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).
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    Image Search Results


    Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), riociguat (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).

    Journal: bioRxiv

    Article Title: Myocardial cGMP-PKG1α dysregulation contributes to VT pathogenesis in type II diabetes and metabolic syndrome

    doi: 10.1101/2025.02.12.638003

    Figure Lengend Snippet: Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), riociguat (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).

    Article Snippet: Riociguat (AmBeed, A255332) was administered by oral gavage at 10 mg/kg once daily for 7 days.

    Techniques: MANN-WHITNEY