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Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), <t>riociguat</t> (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).
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https://www.bioz.com/product/riociguat/bio_rxiv__2025__02__12__638003-76-0-1?v=Ambeed+Inc
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Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), <t>riociguat</t> (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).
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riociguat  (Bayer HealthCare Pharmaceuticals Inc)
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Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), <t>riociguat</t> (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).
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Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), riociguat (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).

Journal: bioRxiv

Article Title: Myocardial cGMP-PKG1α dysregulation contributes to VT pathogenesis in type II diabetes and metabolic syndrome

doi: 10.1101/2025.02.12.638003

Figure Lengend Snippet: Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), riociguat (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).

Article Snippet: Riociguat (AmBeed, A255332) was administered by oral gavage at 10 mg/kg once daily for 7 days.

Techniques: MANN-WHITNEY