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Janssen riociguat
Riociguat, supplied by Janssen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/riociguat/riociguat/pm39679492-636-28-6
Average 90 stars, based on 1 article reviews
riociguat - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Doppler trans-thoracic echocardiography for detection of pulmonary hypertension in adults
Article Snippet: Schermuly 2011 Schermuly RT, Janssen W, Weissmann N, Stasch JP, Grimminger F, Ghofrani HA.Riociguat for the treatment of pulmonary hypertension.

Article Title: Update on pediatric pulmonary arterial hypertension
Article Snippet: The natural history of pediatric pulmonary arterial hypertension (PAH) is associated with a poor prognosis.. Without treatment, elevation of pulmonary arterial pressure and resistance in PAH patients leads to right heart failure, clinical worsening, and death.. Unlike with adult patients, however, PAH in children is intrinsically linked to lung growth.

Article Title: Structure/activity relationships of (M)ANT- and TNP-nucleotides for inhibition of rat soluble guanylyl cyclase α1β1.
Article Snippet: Soluble guanylyl cyclase (sGC) plays an important role in cardiovascular function and catalyzes formation of cGMP. sGC is activated by nitric oxide and allosteric stimulators and activators.. However, despite its therapeutic relevance, the regulatory mechanisms of sGC are still incompletely understood.. Amajor reason for this situation is that no crystal structures of active sGC have been resolved so far.

Article Title: 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.
Article Snippet: Circulation 2009; 119: 2894–2903. https://doi.org/10.1183/13993003.00879-2022 126 EUROPEAN RESPIRATORY JOURNAL ESC/ERS GUIDELINES | M. HUMBERT ET AL. 394 Schermuly RT, Janssen W, Weissmann N, et al. Riociguat for the treatment of pulmonary hypertension.

Article Title: Clinical Significance of Guanylate Cyclase Stimulator, Riociguat, on Right Ventricular Functional Improvement in Patients with Pulmonary Hypertension.
Article Snippet: Background: Riociguat is a soluble guanylate cyclase stimulator that improves hemodynamics in patients with pulmonary hypertension (PH).. Accumulating evidence implicates the additional effect of riociguat on the increase in cardiac output.. However, its mechanisms have not been fully understood.

Article Title: [Optimization of specific therapy for pulmonary hypertension: the possibilities of riociguat].
Article Snippet: Schermuly RT, Janssen W, Weissmann N, et al. Riociguat for the treatment of pulmonary hypertension.

Article Title: Extracellular matrix instability and chronic inflammation underlie maladaptive right ventricular pressure overload remodeling and failure in male mice.
Article Snippet: Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch 836 JP, Ghofrani HA, Seeger W, Schermuly RT, and Novoyatleva T. Effect of Riociguat and Sildenafil on Right 837 Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding.



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Ambeed Inc riociguat a255332
Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), <t>riociguat</t> (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).
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Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), riociguat (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).

Journal: bioRxiv

Article Title: Myocardial cGMP-PKG1α dysregulation contributes to VT pathogenesis in type II diabetes and metabolic syndrome

doi: 10.1101/2025.02.12.638003

Figure Lengend Snippet: Development of ventricular tachycardia (VT) in response to programmed ventricular stimulation in (A) Db/Db mice and (B) high fat high sucrose-fed mice pre-treated for 7 days with vehicle (V), riociguat (Rio) 10 mg/kg, or sildenafil 10 (Sil) 10 mg/kg. *, p<0.05 by Student’s unpaired T test (riociguat graphs) or in sildenafil-treated graphs, by Welch’s T test (Db/Db) or Mann-Whitney test (HFHS).

Article Snippet: Riociguat (AmBeed, A255332) was administered by oral gavage at 10 mg/kg once daily for 7 days.

Techniques: MANN-WHITNEY