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gs 5734  (MedChemExpress)


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    Structured Review

    MedChemExpress gs 5734
    Gs 5734, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 254 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/remdesivir/Remdesivir/bio_rxiv__64898__2026__06__12__731861-75-18-19
    Average 96 stars, based on 254 article reviews
    gs 5734 - by Bioz Stars, 2026-10
    96/100 stars

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    Generated:

    Article Title: Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function.
    Article Snippet: s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 22 M ay 2 02 6 by 1 03 .1 57 .4 8. 61 . was purchased from Sigma-Aldrich (St. Louis, MO, USA; S4441). Remdesivir (GS-5734) was purchased from MedChemExpress (Monmouth Junction, NJ, USA; HY-104077). Stock solutions (10 mM) were prepared by dissolving these compounds in DMSO. Analysis of MDCK cell viability following compound treatment using

    Cell Culture:

    Article Title: Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function.
    Article Snippet: s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 22 M ay 2 02 6 by 1 03 .1 57 .4 8. 61 . was purchased from Sigma-Aldrich (St. Louis, MO, USA; S4441). Remdesivir (GS-5734) was purchased from MedChemExpress (Monmouth Junction, NJ, USA; HY-104077). Stock solutions (10 mM) were prepared by dissolving these compounds in DMSO. Analysis of MDCK cell viability following compound treatment using

    Virus:

    Article Title: Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function.
    Article Snippet: s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 22 M ay 2 02 6 by 1 03 .1 57 .4 8. 61 . was purchased from Sigma-Aldrich (St. Louis, MO, USA; S4441). Remdesivir (GS-5734) was purchased from MedChemExpress (Monmouth Junction, NJ, USA; HY-104077). Stock solutions (10 mM) were prepared by dissolving these compounds in DMSO. Analysis of MDCK cell viability following compound treatment using

    Food & Beverages:

    Article Title: Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function.
    Article Snippet: s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 22 M ay 2 02 6 by 1 03 .1 57 .4 8. 61 . was purchased from Sigma-Aldrich (St. Louis, MO, USA; S4441). Remdesivir (GS-5734) was purchased from MedChemExpress (Monmouth Junction, NJ, USA; HY-104077). Stock solutions (10 mM) were prepared by dissolving these compounds in DMSO. Analysis of MDCK cell viability following compound treatment using

    Transfection:

    Article Title: Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function.
    Article Snippet: s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 22 M ay 2 02 6 by 1 03 .1 57 .4 8. 61 . was purchased from Sigma-Aldrich (St. Louis, MO, USA; S4441). Remdesivir (GS-5734) was purchased from MedChemExpress (Monmouth Junction, NJ, USA; HY-104077). Stock solutions (10 mM) were prepared by dissolving these compounds in DMSO. Analysis of MDCK cell viability following compound treatment using

    Polymerase Chain Reaction:

    Article Title: Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function.
    Article Snippet: s: //j ou rn al s. as m .o rg /jo ur na l/s pe ct ru m o n 22 M ay 2 02 6 by 1 03 .1 57 .4 8. 61 . was purchased from Sigma-Aldrich (St. Louis, MO, USA; S4441). Remdesivir (GS-5734) was purchased from MedChemExpress (Monmouth Junction, NJ, USA; HY-104077). Stock solutions (10 mM) were prepared by dissolving these compounds in DMSO. Analysis of MDCK cell viability following compound treatment using



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    Image Search Results


    PHEV dsRNA serves as a prerequisite for RIG-I-dependent induction of type I IFN. ( A ) Schematic illustration of the proposed mechanisms by which Remdesivir (RDV) and Lopinavir (LPV) suppress PHEV replication. RdRp, RNA-dependent RNA polymerase; 3CLpro, 3C-like protease. ( B ) RDV and LPV suppress PHEV replication. N2a cells were infected with PHEV for 1 h, treated with RDV or LPV (20 μM), and harvested at 24 h post-infection for qRT-PCR analysis of PHEV mRNA levels. ( C ) QRT-PCR analysis of IFNA and IFNB1 mRNA expression as described in panel B . ( D ) QRT-PCR analysis of I RIG-I, IRF3, and IRF7 mRNA expression as described in panel B . ( E ) WB analysis of RIG-I, phosphorylated IRF3 (p-IRF3), p-IRF7, and PHEV N protein as described in panel B . ( F ) Immunostaining assay. N2a cells as indicated in panel B were harvested and immunostained with anti-dsRNA (red) and anti-RIG-I (green) antibodies, DAPI (blue). Scale bar, 10 µm. Data represent mean ± SD (** P < 0.01 and *** P < 0.001 by unpaired two-tailed Student’s t-test).

    Journal: Journal of Virology

    Article Title: Porcine hemagglutinating encephalomyelitis virus nucleocapsid protein targets RIG-I and IRF3 to evade IFN immunity

    doi: 10.1128/jvi.02112-25

    Figure Lengend Snippet: PHEV dsRNA serves as a prerequisite for RIG-I-dependent induction of type I IFN. ( A ) Schematic illustration of the proposed mechanisms by which Remdesivir (RDV) and Lopinavir (LPV) suppress PHEV replication. RdRp, RNA-dependent RNA polymerase; 3CLpro, 3C-like protease. ( B ) RDV and LPV suppress PHEV replication. N2a cells were infected with PHEV for 1 h, treated with RDV or LPV (20 μM), and harvested at 24 h post-infection for qRT-PCR analysis of PHEV mRNA levels. ( C ) QRT-PCR analysis of IFNA and IFNB1 mRNA expression as described in panel B . ( D ) QRT-PCR analysis of I RIG-I, IRF3, and IRF7 mRNA expression as described in panel B . ( E ) WB analysis of RIG-I, phosphorylated IRF3 (p-IRF3), p-IRF7, and PHEV N protein as described in panel B . ( F ) Immunostaining assay. N2a cells as indicated in panel B were harvested and immunostained with anti-dsRNA (red) and anti-RIG-I (green) antibodies, DAPI (blue). Scale bar, 10 µm. Data represent mean ± SD (** P < 0.01 and *** P < 0.001 by unpaired two-tailed Student’s t-test).

    Article Snippet: The Remdesivir and Lopinavir were purchased from MCE.

    Techniques: Infection, Quantitative RT-PCR, Expressing, Immunostaining, Two Tailed Test