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hy 111376  (MedChemExpress)


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    Structured Review

    MedChemExpress hy 111376
    Hy 111376, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pyrrophenone/Pyrrophenone/pm41138926-47-8-18
    Average 94 stars, based on 5 article reviews
    hy 111376 - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Activity Assay:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Infection:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Virus:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Plaque Assay:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Solvent:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Control:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Functional Assay:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Membrane:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Blocking Assay:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Concentration Assay:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Fluorescence:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Transfection:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Inhibition:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Injection:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Microinjection:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Mutagenesis:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Labeling:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.

    Marker:

    Article Title: ProcCluster ® and procaine hydrochloride inhibit the replication of influenza A virus in vitro
    Article Snippet: Bromoenol lacton (Merck, Germany) and pyrrophenone (MedChemExpress, United States) were diluted in DMSO and stored at −20°C.



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    Image Search Results


    Effects of GIVA cPLA 2 inhibitors on cell viability. ( A ) MTT assay for all compounds at 3.5 μΜ. Only pyrrophenone shows significant decrease in cell viability. Statistics obtained by Student’s t -test comparing cells treated with each inhibitor with cells treated with DMSO as vehicle (untreated). # p < 0.0001. DMSO alone had no effect on cell viability at concentrations used (<0.05%, left). Statistics by One-way Anova followed by Dunnett’s multiple comparison test (* p = 0.0224, *** p = 0.0001, **** p < 0.0001). ( B ) IC 50 values obtained following treatment with GK420 or GK484 inhibitors, using nonlinear regression.

    Journal: Biomolecules

    Article Title: A Lipidomic Approach to Studying the Downregulation of Free Fatty Acids by Cytosolic Phospholipase A 2 Inhibitors

    doi: 10.3390/biom15050626

    Figure Lengend Snippet: Effects of GIVA cPLA 2 inhibitors on cell viability. ( A ) MTT assay for all compounds at 3.5 μΜ. Only pyrrophenone shows significant decrease in cell viability. Statistics obtained by Student’s t -test comparing cells treated with each inhibitor with cells treated with DMSO as vehicle (untreated). # p < 0.0001. DMSO alone had no effect on cell viability at concentrations used (<0.05%, left). Statistics by One-way Anova followed by Dunnett’s multiple comparison test (* p = 0.0224, *** p = 0.0001, **** p < 0.0001). ( B ) IC 50 values obtained following treatment with GK420 or GK484 inhibitors, using nonlinear regression.

    Article Snippet: Pyrrophenone and CAY10502 were purchased from Cayman Chemical Company (>98%, Ann Arbor, MI, USA).

    Techniques: MTT Assay, Comparison

    Change in intracellular FFAs upon treatment of SH-SY5Y cells with pyrrophenone and CAY10502.

    Journal: Biomolecules

    Article Title: A Lipidomic Approach to Studying the Downregulation of Free Fatty Acids by Cytosolic Phospholipase A 2 Inhibitors

    doi: 10.3390/biom15050626

    Figure Lengend Snippet: Change in intracellular FFAs upon treatment of SH-SY5Y cells with pyrrophenone and CAY10502.

    Article Snippet: Pyrrophenone and CAY10502 were purchased from Cayman Chemical Company (>98%, Ann Arbor, MI, USA).

    Techniques:

    Ferroptosis inhibition by CEPT1 is partially dependent on phospholipases. (A–D) Pulldown assays were performed with S protein beads (SFB-tagged proteins were used as the baits), and the indicated proteins were detected by WB. (E) Cell death was measured by propidium iodide (PI) staining in control (sgControl), DDHD1 -knockout, or DDHD2 -knockout (sg1/2) 786-O cells overexpressing CEPT1 or transfected with empty vector (EV) treated with 50 nmol/L RSL3 for 24 h. (F) Cell death was measured by PI staining in control (shControl) and ABHD3 -knockdown (sh1/3) 786-O cells overexpressing CEPT1 or transfected with EV treated with 50 nmol/L RSL3 for 24 h. (G and H) Cell death was measured by PI staining in control (sgControl) and PLAA -knockout (sg1/2) 786-O cells overexpressing CEPT1 or transfected with EV treated with 50 nmol/L RSL3 (G) or 10 µmol/L erastin (H) for 24 h. (I and J) Cell death was measured by PI staining in 786-O cells overexpressing CEPT1 or transfected with EV treated with DMSO, 50 nmol/L RSL3 (I), or 10 µmol/L erastin (J) with 1 µmol/L pyrrophenone (PY) or indicated combinations for 24 h. (K) PLA2 enzyme activities were measured in 786-O cells overexpressing CEPT1 WT or indicated mutants or transfected with an empty vector (EV).

    Journal: Protein & Cell

    Article Title: Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis

    doi: 10.1093/procel/pwae004

    Figure Lengend Snippet: Ferroptosis inhibition by CEPT1 is partially dependent on phospholipases. (A–D) Pulldown assays were performed with S protein beads (SFB-tagged proteins were used as the baits), and the indicated proteins were detected by WB. (E) Cell death was measured by propidium iodide (PI) staining in control (sgControl), DDHD1 -knockout, or DDHD2 -knockout (sg1/2) 786-O cells overexpressing CEPT1 or transfected with empty vector (EV) treated with 50 nmol/L RSL3 for 24 h. (F) Cell death was measured by PI staining in control (shControl) and ABHD3 -knockdown (sh1/3) 786-O cells overexpressing CEPT1 or transfected with EV treated with 50 nmol/L RSL3 for 24 h. (G and H) Cell death was measured by PI staining in control (sgControl) and PLAA -knockout (sg1/2) 786-O cells overexpressing CEPT1 or transfected with EV treated with 50 nmol/L RSL3 (G) or 10 µmol/L erastin (H) for 24 h. (I and J) Cell death was measured by PI staining in 786-O cells overexpressing CEPT1 or transfected with EV treated with DMSO, 50 nmol/L RSL3 (I), or 10 µmol/L erastin (J) with 1 µmol/L pyrrophenone (PY) or indicated combinations for 24 h. (K) PLA2 enzyme activities were measured in 786-O cells overexpressing CEPT1 WT or indicated mutants or transfected with an empty vector (EV).

    Article Snippet: Ferroptosis inducer (1S,3R)-RSL3 (#19288), erastin (#17754), arachidonic acid (#90010), and pyrrophenone (#13294) were from Cayman Chemical.

    Techniques: Inhibition, Staining, Control, Knock-Out, Transfection, Plasmid Preparation, Knockdown