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pirfenidone administration  (TargetMol)


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    TargetMol pirfenidone administration
    Pirfenidone Administration, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pirfenidone administration/product/TargetMol
    Average 94 stars, based on 6 article reviews
    pirfenidone administration - by Bioz Stars, 2026-03
    94/100 stars

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    Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), <t>pirfenidone</t> (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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    Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), pirfenidone (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

    Journal: Frontiers in Pharmacology

    Article Title: GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease

    doi: 10.3389/fphar.2025.1671132

    Figure Lengend Snippet: Comparative effects of GTX-11m and approved antifibrotic therapies on fibrotic marker induction in hNLFs. Gene expression levels of relevant fibrotic markers COL1A1, MMP2, ACTA2, FN and TNC , after incubations with TGFβ1 and GTX-11m (5 μM), nintedanib (1 μM), pirfenidone (1 mM), R-268712 (1 μM) or the indicated combinations for 48h (n = 5). Bars show mean ± SD. Mixed-effects analysis with Dunnett’s correction for multiple comparisons was performed in all graphs. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

    Article Snippet: Nintedanib and pirfenidone were both purchased from MedChemExpress (HY-50904 and HY-B0673).

    Techniques: Marker, Gene Expression