Journal: ACS Omega
Article Title: Theranostic Nanoprobes Assisted NIR-II Fluorescence Imaging for Efficient Angiography and Tumor Therapy
doi: 10.1021/acsomega.5c01553
Figure Lengend Snippet: (a) Cytotoxicity of HeLa cells incubated with free IR820, IR-T, and IR-DT at different concentrations (50, 100, 150, and 200 μg/mL) for 4 h. (b) NIR confocal laser scanning microscopic images of HeLa cells incubated with IR-DT nanoprobes. Scale bar = 50 μm. Excitation for the nanoprobes was 640 nm, excitation for HOCHEST was 405 nm. (c) Flow cytometric analysis of HeLa cells incubated with various concentrations (50, 100, 150, and 200 μg/mL) of IR783, IR-T nanoprobes, and IR-DT nanoprobes in aqueous dispersion, respectively.
Article Snippet: For metabolic imaging, IR783 and IR-DT nanoprobes (200 μL, 2.7 mg/kg) were intravenously injected into mice and imaged at different time points (2, 4, 8, 24, 48, and 72 h) by using the NIR-II imaging system (MARS-Pathfinder) under 808 nm laser irradiation.
Techniques: Incubation, Dispersion