Journal: ACS Omega

Article Title: Theranostic Nanoprobes Assisted NIR-II Fluorescence Imaging for Efficient Angiography and Tumor Therapy

doi: 10.1021/acsomega.5c01553

Figure Lengend Snippet: (a) Cytotoxicity of HeLa cells incubated with free IR820, IR-T, and IR-DT at different concentrations (50, 100, 150, and 200 μg/mL) for 4 h. (b) NIR confocal laser scanning microscopic images of HeLa cells incubated with IR-DT nanoprobes. Scale bar = 50 μm. Excitation for the nanoprobes was 640 nm, excitation for HOCHEST was 405 nm. (c) Flow cytometric analysis of HeLa cells incubated with various concentrations (50, 100, 150, and 200 μg/mL) of IR783, IR-T nanoprobes, and IR-DT nanoprobes in aqueous dispersion, respectively.

Article Snippet: For metabolic imaging, IR783 and IR-DT nanoprobes (200 μL, 2.7 mg/kg) were intravenously injected into mice and imaged at different time points (2, 4, 8, 24, 48, and 72 h) by using the NIR-II imaging system (MARS-Pathfinder) under 808 nm laser irradiation.

Techniques: Incubation, Dispersion

Journal: ACS Omega

Article Title: Theranostic Nanoprobes Assisted NIR-II Fluorescence Imaging for Efficient Angiography and Tumor Therapy

doi: 10.1021/acsomega.5c01553

Figure Lengend Snippet: (a) In vivo NIR-II fluorescence imaging of IR-DT nanoprobes and IR783-treated nude mice at different time points (2 h, 4 h, 8 h, 24 h, 48 h, and 72 h). (b) Corresponding fluorescence intensity analysis at different time points in (a). (c) Corresponding quantitative fluorescence analysis of main organs in (d).

Article Snippet: For metabolic imaging, IR783 and IR-DT nanoprobes (200 μL, 2.7 mg/kg) were intravenously injected into mice and imaged at different time points (2, 4, 8, 24, 48, and 72 h) by using the NIR-II imaging system (MARS-Pathfinder) under 808 nm laser irradiation.

Techniques: In Vivo, Fluorescence, Imaging