gpx4 (MedChemExpress)
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gpx4
Gpx4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gpx4/GPX4+Antibody/pm42126735-78-33-35
Average 94 stars, based on 1 article reviews
Gpx4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gpx4/GPX4+Antibody/pm42126735-78-33-35
Average 94 stars, based on 1 article reviews
gpx4 - by Bioz Stars,
2026-09
94/100 stars
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Incubation:Article Title: Inhibition of aerobic glycolysis suppresses ferroptosis via activation of the AMPK-FoxO3a pathway in epileptic rats. Article Snippet: 1 Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266100, Shandong Province, China 2 Department of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China 3 Department of Clinical Pharmacy, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China Abstract Background Ferroptosis has recently been implicated in seizure-induced neurodegeneration, whereas enhanced aerobic glycolysis during seizures may aggravate oxidative stress and ferroptotic damage.. This study investigated whether inhibition of aerobic glycolysis suppresses ferroptosis through activation of the AMP-activated protein kinase (AMPK)–Forkhead box O3a (FoxO3a) signaling pathway in epileptic rats.. Methods and results A pilocarpine (PILO)-induced epilepsy model was established in male Wistar rats. Article Title: miR-495-3p promotes chronic obstructive pulmonary disease by activating ferroptosis in lung epithelial cells through regulation of the ETS1/GPX4 axis Article Snippet: .. To determine the role of Article Title: FGFR1 drives metabolic adaptation associated with temozolomide resistance in glioblastoma. Article Snippet: Therapy resistance is a major limitation in therapeutic efficacy for glioblastoma (GBM) patients, positioning GBM among the deadliest tumor types.. In this work, we have dissected resistance mechanisms in GBM, which resulted in the identification of FGFR1 pathway as a major controller of the signaling and metabolic rewiring associated to temozolomide (TMZ) resistance.. Hence, in FGFR1-positive, p53 WT GBM cells, FGFR1 controls a p53-mediated cell cycle arrest to allow DNA repair in response to TMZ. Article Title: Bazedoxifene rescues hepatocytes from chemically induced oxidative ferroptotic injury in vivo and in vitro by inhibiting protein disulfide isomerase Article Snippet: .. For detection of Blocking Assay:Article Title: FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation. Article Snippet: .. After blocking with 5% non-fat milk for 1 h at RT, the membranes were probed with the following primary antibodies diluted in the appropriate blocking buffe: FBXO39 (1:1000, GTX04746, GeneTex, Irvine, CA, USA), PGC-1α (1:1000, HY-P80783, MCE, Monmouth Junction, NJ, USA), Tfam (1:1000, HPA040648, Atlas Antibodies, Stockholm, Stockholm County, SWE), TOMM20 (1:5000, HY-P86575, MCE, Monmouth Junction, NJ, USA), KDM5A (1:1000, ab78322, Abcam), Pyrolysis Gas Chromatography:Article Title: FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation. Article Snippet: .. After blocking with 5% non-fat milk for 1 h at RT, the membranes were probed with the following primary antibodies diluted in the appropriate blocking buffe: FBXO39 (1:1000, GTX04746, GeneTex, Irvine, CA, USA), PGC-1α (1:1000, HY-P80783, MCE, Monmouth Junction, NJ, USA), Tfam (1:1000, HPA040648, Atlas Antibodies, Stockholm, Stockholm County, SWE), TOMM20 (1:5000, HY-P86575, MCE, Monmouth Junction, NJ, USA), KDM5A (1:1000, ab78322, Abcam), Western Blot:Article Title: Dexamethasone sensitizes lens epithelial cells to ferroptosis through the glucocorticoid receptor/nuclear factor erythroid 2-related factor 2 signaling axis. Article Snippet: Purpose: The aim of this study was to investigate dexamethasone (Dex) involvement in lens epithelial cell (LEC) Transfection:Article Title: miR-495-3p promotes chronic obstructive pulmonary disease by activating ferroptosis in lung epithelial cells through regulation of the ETS1/GPX4 axis Article Snippet: .. To determine the role of AST Assay:Article Title: A sustained-release sinomenine hydrogel targets microglial ferroptosis via Nrf2-hmox1 activation to alleviate diabetic peripheral neuropathy. Article Snippet: Background: Sinomenine (SIN), a bioactive alkaloid from Sinomenium acutum, possesses anti-inflammatory properties, but its efficacy against diabetic peripheral neuropathy (DPN) is limited by poor bioavailability and undefined mechanisms.. Purpose: This study aimed to evaluate the therapeutic effects and mechanism of a SIN-loaded hydrogel (Gel-SIN- Modification:Article Title: A sustained-release sinomenine hydrogel targets microglial ferroptosis via Nrf2-hmox1 activation to alleviate diabetic peripheral neuropathy. Article Snippet: Background: Sinomenine (SIN), a bioactive alkaloid from Sinomenium acutum, possesses anti-inflammatory properties, but its efficacy against diabetic peripheral neuropathy (DPN) is limited by poor bioavailability and undefined mechanisms.. Purpose: This study aimed to evaluate the therapeutic effects and mechanism of a SIN-loaded hydrogel (Gel-SIN- Encapsulation:Article Title: A sustained-release sinomenine hydrogel targets microglial ferroptosis via Nrf2-hmox1 activation to alleviate diabetic peripheral neuropathy. Article Snippet: Background: Sinomenine (SIN), a bioactive alkaloid from Sinomenium acutum, possesses anti-inflammatory properties, but its efficacy against diabetic peripheral neuropathy (DPN) is limited by poor bioavailability and undefined mechanisms.. Purpose: This study aimed to evaluate the therapeutic effects and mechanism of a SIN-loaded hydrogel (Gel-SIN- Immunofluorescence:Article Title: A sustained-release sinomenine hydrogel targets microglial ferroptosis via Nrf2-hmox1 activation to alleviate diabetic peripheral neuropathy. Article Snippet: Background: Sinomenine (SIN), a bioactive alkaloid from Sinomenium acutum, possesses anti-inflammatory properties, but its efficacy against diabetic peripheral neuropathy (DPN) is limited by poor bioavailability and undefined mechanisms.. Purpose: This study aimed to evaluate the therapeutic effects and mechanism of a SIN-loaded hydrogel (Gel-SIN- Multiple Displacement Amplification:Article Title: A sustained-release sinomenine hydrogel targets microglial ferroptosis via Nrf2-hmox1 activation to alleviate diabetic peripheral neuropathy. Article Snippet: Background: Sinomenine (SIN), a bioactive alkaloid from Sinomenium acutum, possesses anti-inflammatory properties, but its efficacy against diabetic peripheral neuropathy (DPN) is limited by poor bioavailability and undefined mechanisms.. Purpose: This study aimed to evaluate the therapeutic effects and mechanism of a SIN-loaded hydrogel (Gel-SIN- Saline:Article Title: A sustained-release sinomenine hydrogel targets microglial ferroptosis via Nrf2-hmox1 activation to alleviate diabetic peripheral neuropathy. Article Snippet: Background: Sinomenine (SIN), a bioactive alkaloid from Sinomenium acutum, possesses anti-inflammatory properties, but its efficacy against diabetic peripheral neuropathy (DPN) is limited by poor bioavailability and undefined mechanisms.. Purpose: This study aimed to evaluate the therapeutic effects and mechanism of a SIN-loaded hydrogel (Gel-SIN- |
