dorsomorphin  (Tocris)

Journal: Tumour Virus Research

Article Title: Ad-VT oncolytic adenovirus suppresses bladder cancer via cAMP-dependent AMPK-Raptor activation and G2/M arrest

doi: 10.1016/j.tvr.2026.200337

Figure Lengend Snippet: Inhibitory effect of Ad-VT on UM-UC-3 cells in vitro and in vivo through the AMPK-Raptor pathway. (A, B) The expression levels of p-AMPK, AMPK, p-Raptor, Raptor, p-mTOR, and mTOR at 24h after Ad-VT infection (MOI = 100) of UM-UC-3 cells and pretreatment (2h) with a vehicle, Dorsomorphin (1.25 μM) or transfection with the control or Raptor siRNA. (C, D) The viability of UM-UC-3 cells and 5637 cells that were pretreated with Dorsomorphin (B) or Raptor siRNA (C). (E, F) Effect of Dorsomorphin on tumor volume (D) and survival rate (E) of nude mice treated with PBS or Ad-VT. (G) The effect of Raptor siRNA on survival rate of nude mice treated with PBS or Ad-VT treatment. Data are presented as mean ± SEM, ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.

Article Snippet: Dorsomorphin (HY-13418 A), TC11 (HY-129478), and Forskolin (HY-15371) were purchased from MedChemExpress.

Techniques: In Vitro, In Vivo, Expressing, Infection, Transfection, Control

Journal: Poultry Science

Article Title: RESEARCH NOTE: Effect of inhibition of bone morphogenetic protein signaling pathway by dorsomorphin on the establishment of embryo polarity

doi: 10.1016/j.psj.2026.106644

Figure Lengend Snippet: Dose-dependent effect of dorsomorphin on primitive streak formation. Chick embryos at EGK stage X-XI are cultured ex-ovo for 21 hours, with administration of different concentrations of dorsomorphin. (A-C) Representative images showing three types of morphology of the primitive streak: normal (A), truncated (B), and ring-shaped (C). cBRA expression marks primitive streak cells. Orientation of embryos is indicated in (A). (D) Numerical data of the morphological types at various concentrations of dorsomorphin (DM). n for each condition: 6, 6, 6, 7, 6, 8, 7, and 6, in order of increasing the concentration of dorsomorphin (0, 0.1, 0.25, 0.5, 1, 5, 10, and 20 μM). Chi-square test: p = 1.56e-08. Scale bars: 1 mm.

Article Snippet: For dorsomorphin (Tocris, 3093) treatment to the whole embryo, it was diluted first in phosphate-buffered saline (1:10 v:v) and then in albumen (9:10 v:v), which was used for ex ovo culture.

Techniques: Cell Culture, Expressing, Concentration Assay

Journal: Poultry Science

Article Title: RESEARCH NOTE: Effect of inhibition of bone morphogenetic protein signaling pathway by dorsomorphin on the establishment of embryo polarity

doi: 10.1016/j.psj.2026.106644

Figure Lengend Snippet: Enhanced morphological change in isolated anterior cut-half embryos by dorsomorphin treatment . Isolated anterior cut-half embryos are cultured ex-ovo for 9 hours with administration of 0.02% DMSO (control) or 20 μM dorsomorphin. (A) 0.02% DMSO. (B) 20 μM dorsomorphin (DM). A’ and B’ are magnified views of the boxed region in (A) and (B), respectively. cVG1 expression marks the primitive-streak forming region. (C) Comparison of the angle of the groove between the control and DM treatment. Dots represent each data. n = 17 and 26 in the control and DM groups, respectively. Unpaired Student’s t-test (two-sided): **** p < 0.0001. Scale bars: 1 mm.

Article Snippet: For dorsomorphin (Tocris, 3093) treatment to the whole embryo, it was diluted first in phosphate-buffered saline (1:10 v:v) and then in albumen (9:10 v:v), which was used for ex ovo culture.

Techniques: Isolation, Cell Culture, Control, Expressing, Comparison