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cnr2  (Bioss)


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    Bioss cnr2
    Cnr2, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnr2/product/Bioss
    Average 93 stars, based on 10 article reviews
    cnr2 - by Bioz Stars, 2026-03
    93/100 stars

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    <t>CB</t> <t>2</t> activation reduces the number of infected cells without altering HIV receptor expression. a , b. Bulk RNA-seq analysis showing the expression of key endocannabinoid system genes in ( a ) MDMs and ( b ) iMg. c. Representative images of iMg immunostained for CD4 (red), CCR5 (green), and DAPI (blue). d. Quantification of CD4 and CCR5 expression. Each symbol represents the average of 2 wells/condition. n = 3 differentiations from 2 iMg lines. e. Representative images of iMg immunostained for HIV p24. f. Quantification of CD4 and CCR5 expression. Each symbol represents the average of 2 wells/condition. n = 3 differentiations from 2 iMg lines. One-way analysis of variance (ANOVA) with Dunnett’s correction for multiple comparisons. * p < 0.05; ns, not significant
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    Image Search Results


    mRNA expression of the cannabinoid-related receptors Cnr1 ( A ), Cnr2 ( B ), Gpr55 ( C ), Pparα ( D ), and Trpv1 ( E ) in hippocampal astrocytes from 3×Tg-AD offspring of both sexes born to control and PEE mothers. Data are expressed as the mean ± S.E.M. ( n = 5–9). Relevant p values from the two-way ANOVA are shown below each graph, with significant p -values highlighted in bold. Tukey’s test: * p < 0.05. See also effect sizes in the .

    Journal: International Journal of Molecular Sciences

    Article Title: Perinatal Ethanol Exposure Induces Astrogliosis and Decreases GRP55/PEA-Mediated Neuroprotection in Hippocampal Astrocytes of the 3×Tg Alzheimer’s Animal Model

    doi: 10.3390/ijms262211154

    Figure Lengend Snippet: mRNA expression of the cannabinoid-related receptors Cnr1 ( A ), Cnr2 ( B ), Gpr55 ( C ), Pparα ( D ), and Trpv1 ( E ) in hippocampal astrocytes from 3×Tg-AD offspring of both sexes born to control and PEE mothers. Data are expressed as the mean ± S.E.M. ( n = 5–9). Relevant p values from the two-way ANOVA are shown below each graph, with significant p -values highlighted in bold. Tukey’s test: * p < 0.05. See also effect sizes in the .

    Article Snippet: Cnr2 (CB2) , Mm02620087 , NM_009924.4 , 171.

    Techniques: Expressing, Control

    CB 2 activation reduces the number of infected cells without altering HIV receptor expression. a , b. Bulk RNA-seq analysis showing the expression of key endocannabinoid system genes in ( a ) MDMs and ( b ) iMg. c. Representative images of iMg immunostained for CD4 (red), CCR5 (green), and DAPI (blue). d. Quantification of CD4 and CCR5 expression. Each symbol represents the average of 2 wells/condition. n = 3 differentiations from 2 iMg lines. e. Representative images of iMg immunostained for HIV p24. f. Quantification of CD4 and CCR5 expression. Each symbol represents the average of 2 wells/condition. n = 3 differentiations from 2 iMg lines. One-way analysis of variance (ANOVA) with Dunnett’s correction for multiple comparisons. * p < 0.05; ns, not significant

    Journal: Journal of Neuroimmune Pharmacology

    Article Title: Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

    doi: 10.1007/s11481-025-10254-x

    Figure Lengend Snippet: CB 2 activation reduces the number of infected cells without altering HIV receptor expression. a , b. Bulk RNA-seq analysis showing the expression of key endocannabinoid system genes in ( a ) MDMs and ( b ) iMg. c. Representative images of iMg immunostained for CD4 (red), CCR5 (green), and DAPI (blue). d. Quantification of CD4 and CCR5 expression. Each symbol represents the average of 2 wells/condition. n = 3 differentiations from 2 iMg lines. e. Representative images of iMg immunostained for HIV p24. f. Quantification of CD4 and CCR5 expression. Each symbol represents the average of 2 wells/condition. n = 3 differentiations from 2 iMg lines. One-way analysis of variance (ANOVA) with Dunnett’s correction for multiple comparisons. * p < 0.05; ns, not significant

    Article Snippet: Custom TaqMan assay plates preloaded with the following human primer/probe pairs (Thermo Fisher Scientific, Waltham, MA) were used: GAPDH , Hs02786624_g1; CD4 , Hs01058407_m1, CCR5 , Hs99999149_s1; CXCR4 , Hs00607978_s1; CNR1 , Hs01038522_s1; CNR2 , Hs00361490_m1; GPR55 , Hs00271662_s1; IL1B , Hs01555410_m1; IL18 , Hs01038788_m1; NLRP3 , Hs00918082_m1; PYCARD , Hs01547324_gH; IL6 , Hs00174131_m1; TNFA , Hs00174128_m1; and CASP1 , Hs00354836_m1.

    Techniques: Activation Assay, Infection, Expressing, RNA Sequencing

    CB 2 agonists dose-dependently reduce HIV replication in macrophages and microglia. a , b. HIV p24 levels in supernatants of monocyte-derived macrophages (MDMs, n = 7) ( a ) and human induced pluripotent stem cell-derived microglia (iMg, n = 3) ( b ), normalized to the HIV + vehicle. Two-way ANOVA with Dunnett’s correction for multiple comparisons. * p < 0.05, ** p < 0.01. c , d. Bulk RNA-seq data showing count/million reads of key endocannabinoid system genes in MDMs ( c ) and iMg ( d )

    Journal: Journal of Neuroimmune Pharmacology

    Article Title: Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

    doi: 10.1007/s11481-025-10254-x

    Figure Lengend Snippet: CB 2 agonists dose-dependently reduce HIV replication in macrophages and microglia. a , b. HIV p24 levels in supernatants of monocyte-derived macrophages (MDMs, n = 7) ( a ) and human induced pluripotent stem cell-derived microglia (iMg, n = 3) ( b ), normalized to the HIV + vehicle. Two-way ANOVA with Dunnett’s correction for multiple comparisons. * p < 0.05, ** p < 0.01. c , d. Bulk RNA-seq data showing count/million reads of key endocannabinoid system genes in MDMs ( c ) and iMg ( d )

    Article Snippet: Custom TaqMan assay plates preloaded with the following human primer/probe pairs (Thermo Fisher Scientific, Waltham, MA) were used: GAPDH , Hs02786624_g1; CD4 , Hs01058407_m1, CCR5 , Hs99999149_s1; CXCR4 , Hs00607978_s1; CNR1 , Hs01038522_s1; CNR2 , Hs00361490_m1; GPR55 , Hs00271662_s1; IL1B , Hs01555410_m1; IL18 , Hs01038788_m1; NLRP3 , Hs00918082_m1; PYCARD , Hs01547324_gH; IL6 , Hs00174131_m1; TNFA , Hs00174128_m1; and CASP1 , Hs00354836_m1.

    Techniques: Derivative Assay, RNA Sequencing

    CB 2 agonists reduce global cytokine release following HIV infection in MDMs but not in iMg. a , b. Cytokine levels in cell-free supernatants of MDM ( a ) and ( b ) iMg cultures were measured with Bio-Plex Pro 48-Plex human cytokine screening panel. Heatmaps show log 2 fold changes from the HIV + vehicle condition. Supernatants were pooled from 4 wells/condition at days postinfection 9 (DPI 9) and assayed in duplicate. n = 6 MDM donors and 3 iMg lines. Student’s t test, ** p < 0.01. c. Levels of cytokines reportedly associated with HIV-induced brain injury in MDM and iMg supernatants, measured with Bio-Plex Pro 48-Plex human cytokine screening panel. d , e. Levels of tumor necrosis factor alpha (TNF-α) and IL-6 in ( d ) MDM and ( e ) iMg culture supernatants, measured with AlphaLISA. n = 6 MDM donors and 3 iMg lines. Student’s t test, * p < 0.05

    Journal: Journal of Neuroimmune Pharmacology

    Article Title: Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

    doi: 10.1007/s11481-025-10254-x

    Figure Lengend Snippet: CB 2 agonists reduce global cytokine release following HIV infection in MDMs but not in iMg. a , b. Cytokine levels in cell-free supernatants of MDM ( a ) and ( b ) iMg cultures were measured with Bio-Plex Pro 48-Plex human cytokine screening panel. Heatmaps show log 2 fold changes from the HIV + vehicle condition. Supernatants were pooled from 4 wells/condition at days postinfection 9 (DPI 9) and assayed in duplicate. n = 6 MDM donors and 3 iMg lines. Student’s t test, ** p < 0.01. c. Levels of cytokines reportedly associated with HIV-induced brain injury in MDM and iMg supernatants, measured with Bio-Plex Pro 48-Plex human cytokine screening panel. d , e. Levels of tumor necrosis factor alpha (TNF-α) and IL-6 in ( d ) MDM and ( e ) iMg culture supernatants, measured with AlphaLISA. n = 6 MDM donors and 3 iMg lines. Student’s t test, * p < 0.05

    Article Snippet: Custom TaqMan assay plates preloaded with the following human primer/probe pairs (Thermo Fisher Scientific, Waltham, MA) were used: GAPDH , Hs02786624_g1; CD4 , Hs01058407_m1, CCR5 , Hs99999149_s1; CXCR4 , Hs00607978_s1; CNR1 , Hs01038522_s1; CNR2 , Hs00361490_m1; GPR55 , Hs00271662_s1; IL1B , Hs01555410_m1; IL18 , Hs01038788_m1; NLRP3 , Hs00918082_m1; PYCARD , Hs01547324_gH; IL6 , Hs00174131_m1; TNFA , Hs00174128_m1; and CASP1 , Hs00354836_m1.

    Techniques: Infection

    RNA-seq identifies convergent and divergent responses to CB 2 signaling between HIV-infected MDMs and iMg. a , b . Top 10 GO biological process gene sets enriched in the significant differentially expressed genes (DEGs) in comparison between HIV-infected/vehicle-treated and HIV-infected/JWH-133 treated ( a ) MDMs and ( b ) iMg. c. Top 10 KEGG gene sets enriched in the significant DEGs in comparison between HIV-infected/JWH-133-treated MDMs and iMg. n = 2 MDM donors and 2 iMg lines

    Journal: Journal of Neuroimmune Pharmacology

    Article Title: Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

    doi: 10.1007/s11481-025-10254-x

    Figure Lengend Snippet: RNA-seq identifies convergent and divergent responses to CB 2 signaling between HIV-infected MDMs and iMg. a , b . Top 10 GO biological process gene sets enriched in the significant differentially expressed genes (DEGs) in comparison between HIV-infected/vehicle-treated and HIV-infected/JWH-133 treated ( a ) MDMs and ( b ) iMg. c. Top 10 KEGG gene sets enriched in the significant DEGs in comparison between HIV-infected/JWH-133-treated MDMs and iMg. n = 2 MDM donors and 2 iMg lines

    Article Snippet: Custom TaqMan assay plates preloaded with the following human primer/probe pairs (Thermo Fisher Scientific, Waltham, MA) were used: GAPDH , Hs02786624_g1; CD4 , Hs01058407_m1, CCR5 , Hs99999149_s1; CXCR4 , Hs00607978_s1; CNR1 , Hs01038522_s1; CNR2 , Hs00361490_m1; GPR55 , Hs00271662_s1; IL1B , Hs01555410_m1; IL18 , Hs01038788_m1; NLRP3 , Hs00918082_m1; PYCARD , Hs01547324_gH; IL6 , Hs00174131_m1; TNFA , Hs00174128_m1; and CASP1 , Hs00354836_m1.

    Techniques: RNA Sequencing, Infection, Comparison

    CB 2 activation has minimal impact on transcriptional priming of the NLRP3 inflammasome in MDMs and iMg with established HIV infection. (a) NLRP3 inflammasome gene expression in MDMs on DPI 9, determined with qRT-PCR, represented as log 2 fold change from Mock + Veh. n = 3 MDM donors. (b) NLRP3 inflammasome gene expression in iMg on DPI 9, determined with bulk RNA-seq. n = 3 iMg lines

    Journal: Journal of Neuroimmune Pharmacology

    Article Title: Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

    doi: 10.1007/s11481-025-10254-x

    Figure Lengend Snippet: CB 2 activation has minimal impact on transcriptional priming of the NLRP3 inflammasome in MDMs and iMg with established HIV infection. (a) NLRP3 inflammasome gene expression in MDMs on DPI 9, determined with qRT-PCR, represented as log 2 fold change from Mock + Veh. n = 3 MDM donors. (b) NLRP3 inflammasome gene expression in iMg on DPI 9, determined with bulk RNA-seq. n = 3 iMg lines

    Article Snippet: Custom TaqMan assay plates preloaded with the following human primer/probe pairs (Thermo Fisher Scientific, Waltham, MA) were used: GAPDH , Hs02786624_g1; CD4 , Hs01058407_m1, CCR5 , Hs99999149_s1; CXCR4 , Hs00607978_s1; CNR1 , Hs01038522_s1; CNR2 , Hs00361490_m1; GPR55 , Hs00271662_s1; IL1B , Hs01555410_m1; IL18 , Hs01038788_m1; NLRP3 , Hs00918082_m1; PYCARD , Hs01547324_gH; IL6 , Hs00174131_m1; TNFA , Hs00174128_m1; and CASP1 , Hs00354836_m1.

    Techniques: Activation Assay, Infection, Gene Expression, Quantitative RT-PCR, RNA Sequencing

    In iMg, CB 2 -specific agonists impair HIV-induced NLRP3 inflammasome activation with a corresponding increase in autophagosome number. (a) Quantification of the number of NLRP3 + /ASC + specks in iMg detected with immunostaining. Average of 2 wells/condition from 3 differentiations in 2 iMg lines, one-way ANOVA with Dunnett’s correction for multiple comparisons. * p < 0.05. (b) Autophagic vacuoles measured by an autophagy assay. n = 3 iMg lines, one-way ANOVA with Dunnett’s correction for multiple comparisons, * p < 0.05. (c) Caspase 1 activity measured by the Caspase-Glo 1 inflammasome assay, with results normalized to HIV + Veh. n = 3 iMg lines, one-way ANOVA with Dunnett’s correction for multiple comparisons, * p < 0.05. (d) Levels of IL-1β in iMg supernatants, measured by AlphaLISA. n = 3 iMg lines, one-way ANOVA with Dunnett’s correction for multiple comparisons, ** p < 0.01; ns, not significant

    Journal: Journal of Neuroimmune Pharmacology

    Article Title: Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia

    doi: 10.1007/s11481-025-10254-x

    Figure Lengend Snippet: In iMg, CB 2 -specific agonists impair HIV-induced NLRP3 inflammasome activation with a corresponding increase in autophagosome number. (a) Quantification of the number of NLRP3 + /ASC + specks in iMg detected with immunostaining. Average of 2 wells/condition from 3 differentiations in 2 iMg lines, one-way ANOVA with Dunnett’s correction for multiple comparisons. * p < 0.05. (b) Autophagic vacuoles measured by an autophagy assay. n = 3 iMg lines, one-way ANOVA with Dunnett’s correction for multiple comparisons, * p < 0.05. (c) Caspase 1 activity measured by the Caspase-Glo 1 inflammasome assay, with results normalized to HIV + Veh. n = 3 iMg lines, one-way ANOVA with Dunnett’s correction for multiple comparisons, * p < 0.05. (d) Levels of IL-1β in iMg supernatants, measured by AlphaLISA. n = 3 iMg lines, one-way ANOVA with Dunnett’s correction for multiple comparisons, ** p < 0.01; ns, not significant

    Article Snippet: Custom TaqMan assay plates preloaded with the following human primer/probe pairs (Thermo Fisher Scientific, Waltham, MA) were used: GAPDH , Hs02786624_g1; CD4 , Hs01058407_m1, CCR5 , Hs99999149_s1; CXCR4 , Hs00607978_s1; CNR1 , Hs01038522_s1; CNR2 , Hs00361490_m1; GPR55 , Hs00271662_s1; IL1B , Hs01555410_m1; IL18 , Hs01038788_m1; NLRP3 , Hs00918082_m1; PYCARD , Hs01547324_gH; IL6 , Hs00174131_m1; TNFA , Hs00174128_m1; and CASP1 , Hs00354836_m1.

    Techniques: Activation Assay, Immunostaining, Activity Assay