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cnqx  (Tocris)


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    Tocris cnqx
    Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, <t>CNQX,</t> <t>DAP5,</t> and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).
    Cnqx, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 2876 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cnqx/product/Tocris
    Average 96 stars, based on 2876 article reviews
    cnqx - by Bioz Stars, 2026-05
    96/100 stars

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    1) Product Images from "Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice"

    Article Title: Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice

    Journal: Endocrinology

    doi: 10.1210/endocr/bqag034

    Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, CNQX, DAP5, and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).
    Figure Legend Snippet: Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, CNQX, DAP5, and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).

    Techniques Used: Membrane



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    Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, <t>CNQX,</t> <t>DAP5,</t> and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).
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    Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, CNQX, DAP5, and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).

    Journal: Endocrinology

    Article Title: Robust serotonin activation of the kisspeptin GnRH pulse generator in male and female mice

    doi: 10.1210/endocr/bqag034

    Figure Lengend Snippet: Effects of serotonin and 5-HT receptor compounds on ARN KISS neuron firing in acute brain slices from diestrous female mice. (A) Robust excitatory effect of 90 seconds puff of 40 µM serotonin on firing rate of a middle ARN kisspeptin neuron. (B) Inhibitory effect of 90 seconds puff of 60 µM serotonin on firing rate of a caudal ARN kisspeptin neuron initially stimulated to fire by a 200 nM puff of NKB. (C) Rostral ARN kisspeptin neuron not responding to 60 µM puffs of serotonin but later activated by NKB. (D) Summary of percentage of rostral (rARN), middle (mARN), and caudal (cARN) kisspeptin neurons excited or inhibited by serotonin. (E) Caudal ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of methiothepin (100 µM). (F) Middle ARN kisspeptin neuron in which the excitatory effect of serotonin (40 µM) is blocked by methiothepin (100 µM). (G) Middle ARN kisspeptin neuron activated by serotonin (40 µM) in the absence and presence of SB228357 (100 µM). (H) Caudal ARN kisspeptin neuron in which zacopride (2 µM) facilitates serotonin excitation. (I) Whole-cell recording from an ARN KISS neuron in the continuous presence of TTX, CNQX, DAP5, and bicuculline, showing depolarization during bath application of 5-HT (30 µM). (J) Summary of mean membrane potential measured predrug, during 5-HT application, and following wash ( P < .001; n = 4 animals).

    Article Snippet: Stock solutions of GABAzine (SR95531, 5 mM, Tocris, UK), CNQX (10 mM, Tocris, UK), and DAP5, (50 mM, Tocris, UK) were prepared with Milli-Q water or NaOH for DAP5.

    Techniques: Membrane