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chi3l1  (Proteintech)


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    Proteintech chi3l1
    Chi3l1, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 45 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/chi3l1/CHI3L1%2FYKL40+Antibody/10__1016_slash_j__fbp__2026__03__030-53-59-70
    Average 95 stars, based on 45 article reviews
    chi3l1 - by Bioz Stars, 2026-09
    95/100 stars

    Images

    Related Articles

    other:

    Article Title: Molecular Mechanisms of Rotator Cuff Degeneration Identified by Spatial Transcriptomics and Multiplex Immunofluorescence
    Article Snippet: CHI3L1 (CHI3L1/YKL40 Polyclonal antibody) , Proteintech , 12036‐1‐AP , 1:200.

    Immunohistochemistry:

    Article Title: Clinical and molecular features of primary gliosarcoma with digital spatial whole-transcriptome analysis of glial and mesenchymal components
    Article Snippet: Immunohistochemistry for LEF1 was performed with clone EP310 (Cell Marque, predilute) on a Ventana Ultra stainer with DAB Ultra View detection kit. .. Immunohistochemistry for CHI3L1 was performed using CHI3L1 antibody (Proteintech 12036-1-AP), antigen retrieval with citrate buffer pH 6.0 at 80° C for 45 minutes, blocking by 3% milk solution for 15 minutes, and primary antibody 1:500 overnight at 4° C. Secondary antibody (Vector Laboratories BA-1000 1:800) was applied for 1 hour at room temperature and detected by incubation with DAB solution. ..

    Blocking Assay:

    Article Title: Clinical and molecular features of primary gliosarcoma with digital spatial whole-transcriptome analysis of glial and mesenchymal components
    Article Snippet: Immunohistochemistry for LEF1 was performed with clone EP310 (Cell Marque, predilute) on a Ventana Ultra stainer with DAB Ultra View detection kit. .. Immunohistochemistry for CHI3L1 was performed using CHI3L1 antibody (Proteintech 12036-1-AP), antigen retrieval with citrate buffer pH 6.0 at 80° C for 45 minutes, blocking by 3% milk solution for 15 minutes, and primary antibody 1:500 overnight at 4° C. Secondary antibody (Vector Laboratories BA-1000 1:800) was applied for 1 hour at room temperature and detected by incubation with DAB solution. ..

    Incubation:

    Article Title: Clinical and molecular features of primary gliosarcoma with digital spatial whole-transcriptome analysis of glial and mesenchymal components
    Article Snippet: Immunohistochemistry for LEF1 was performed with clone EP310 (Cell Marque, predilute) on a Ventana Ultra stainer with DAB Ultra View detection kit. .. Immunohistochemistry for CHI3L1 was performed using CHI3L1 antibody (Proteintech 12036-1-AP), antigen retrieval with citrate buffer pH 6.0 at 80° C for 45 minutes, blocking by 3% milk solution for 15 minutes, and primary antibody 1:500 overnight at 4° C. Secondary antibody (Vector Laboratories BA-1000 1:800) was applied for 1 hour at room temperature and detected by incubation with DAB solution. ..

    MTT Assay:

    Article Title: Pleurotus citrinopileatus polysaccharide inhibits glioma growth by downregulating the expression of CHI3L1 CHI3L1 as a therapeutic target in glioma
    Article Snippet: Pleurotus citrinopileatus polysaccharide (PCFP) demonstrates anti-glioma potential.. We found that PCFP significantly inhibited the survival rate of glioma cells as determined by MTT assay.. Additionally, 100 mg/kg PCFP significantly inhibited the growth of U251 tumors in nude mice xenograft models, with a tumor inhibition rate of 61.41%; no significant toxicity was observed in organs such as the liver, spleen, or heart.

    Bioprocessing:

    Article Title: Pleurotus citrinopileatus polysaccharide inhibits glioma growth by downregulating the expression of CHI3L1 CHI3L1 as a therapeutic target in glioma
    Article Snippet: Pleurotus citrinopileatus polysaccharide (PCFP) demonstrates anti-glioma potential.. We found that PCFP significantly inhibited the survival rate of glioma cells as determined by MTT assay.. Additionally, 100 mg/kg PCFP significantly inhibited the growth of U251 tumors in nude mice xenograft models, with a tumor inhibition rate of 61.41%; no significant toxicity was observed in organs such as the liver, spleen, or heart.



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    Characterization of TM and TMSC markers under TGF-β2 treatment. ( A–D ) <t>CHI3L1</t> and MYOC expression in TM cells treated with dexamethasone (Dex, 100 nM, 5 days). Immunofluorescent staining is shown in ( A ), quantitative analyses in ( B ), Western blotting results in ( C ), and densitometric analyses in ( D ). ( E–H ) CHI3L1 expression in TM cells and TMSCs and OCT4 expression in TMSCs under control and TGF-β2 (3 ng/mL, 5 days) conditions. Immunofluorescent staining is shown in ( E , F ), and corresponding quantitative analyses are shown in ( G , H ). ( I–L ) Western blotting analysis of CHI3L1 and OCT4 expression in TMSCs ( I ) and CHI3L1 expression in TM cells ( K ) under control and TGF-β2 treatment, with densitometric analyses shown in ( J–L ). Data are presented as mean ± SD ( n ≥ 3). Statistical analyses were performed using two-tailed unpaired t -tests. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
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    LMS percentiles for urinary (a) KIM-1, (b, boys; c, girls) NGAL, (d, boys; e, girls) DKK3, and (f) <t>CHI3L1</t> to creatinine ratios in the HARP cohort. The 5th, 10th, 25th (dashed line), 50th (bold line), 75th (dashed line), 90th, and 95th percentiles are given. Data on boys and girls is given as blue triangles and orange dots, respectively. CHI3L1, chitinase 3-like protein-1; crea, creatinine; DKK3, dickkopf-3; KIM-1, kidney-injury molecule-1; LMS, lambda-mu-sigma; NGAL, neutrophil gelatinase-associated lipocalin.
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    LMS percentiles for urinary (a) KIM-1, (b, boys; c, girls) NGAL, (d, boys; e, girls) DKK3, and (f) <t>CHI3L1</t> to creatinine ratios in the HARP cohort. The 5th, 10th, 25th (dashed line), 50th (bold line), 75th (dashed line), 90th, and 95th percentiles are given. Data on boys and girls is given as blue triangles and orange dots, respectively. CHI3L1, chitinase 3-like protein-1; crea, creatinine; DKK3, dickkopf-3; KIM-1, kidney-injury molecule-1; LMS, lambda-mu-sigma; NGAL, neutrophil gelatinase-associated lipocalin.
    Chi3l1, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    LMS percentiles for urinary (a) KIM-1, (b, boys; c, girls) NGAL, (d, boys; e, girls) DKK3, and (f) <t>CHI3L1</t> to creatinine ratios in the HARP cohort. The 5th, 10th, 25th (dashed line), 50th (bold line), 75th (dashed line), 90th, and 95th percentiles are given. Data on boys and girls is given as blue triangles and orange dots, respectively. CHI3L1, chitinase 3-like protein-1; crea, creatinine; DKK3, dickkopf-3; KIM-1, kidney-injury molecule-1; LMS, lambda-mu-sigma; NGAL, neutrophil gelatinase-associated lipocalin.
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    LMS percentiles for urinary (a) KIM-1, (b, boys; c, girls) NGAL, (d, boys; e, girls) DKK3, and (f) <t>CHI3L1</t> to creatinine ratios in the HARP cohort. The 5th, 10th, 25th (dashed line), 50th (bold line), 75th (dashed line), 90th, and 95th percentiles are given. Data on boys and girls is given as blue triangles and orange dots, respectively. CHI3L1, chitinase 3-like protein-1; crea, creatinine; DKK3, dickkopf-3; KIM-1, kidney-injury molecule-1; LMS, lambda-mu-sigma; NGAL, neutrophil gelatinase-associated lipocalin.
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    Image Search Results


    Characterization of TM and TMSC markers under TGF-β2 treatment. ( A–D ) CHI3L1 and MYOC expression in TM cells treated with dexamethasone (Dex, 100 nM, 5 days). Immunofluorescent staining is shown in ( A ), quantitative analyses in ( B ), Western blotting results in ( C ), and densitometric analyses in ( D ). ( E–H ) CHI3L1 expression in TM cells and TMSCs and OCT4 expression in TMSCs under control and TGF-β2 (3 ng/mL, 5 days) conditions. Immunofluorescent staining is shown in ( E , F ), and corresponding quantitative analyses are shown in ( G , H ). ( I–L ) Western blotting analysis of CHI3L1 and OCT4 expression in TMSCs ( I ) and CHI3L1 expression in TM cells ( K ) under control and TGF-β2 treatment, with densitometric analyses shown in ( J–L ). Data are presented as mean ± SD ( n ≥ 3). Statistical analyses were performed using two-tailed unpaired t -tests. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.

    Journal: Investigative Ophthalmology & Visual Science

    Article Title: Hepatocyte Growth Factor Confers Trabecular Meshwork Stem Cell Resilience and Paracrine Protection of Trabecular Meshwork Cells in Glaucoma

    doi: 10.1167/iovs.67.4.1

    Figure Lengend Snippet: Characterization of TM and TMSC markers under TGF-β2 treatment. ( A–D ) CHI3L1 and MYOC expression in TM cells treated with dexamethasone (Dex, 100 nM, 5 days). Immunofluorescent staining is shown in ( A ), quantitative analyses in ( B ), Western blotting results in ( C ), and densitometric analyses in ( D ). ( E–H ) CHI3L1 expression in TM cells and TMSCs and OCT4 expression in TMSCs under control and TGF-β2 (3 ng/mL, 5 days) conditions. Immunofluorescent staining is shown in ( E , F ), and corresponding quantitative analyses are shown in ( G , H ). ( I–L ) Western blotting analysis of CHI3L1 and OCT4 expression in TMSCs ( I ) and CHI3L1 expression in TM cells ( K ) under control and TGF-β2 treatment, with densitometric analyses shown in ( J–L ). Data are presented as mean ± SD ( n ≥ 3). Statistical analyses were performed using two-tailed unpaired t -tests. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.

    Article Snippet: Membranes were blocked with EveryBlot Blocking Buffer (Bio-Rad, Hercules, CA, USA) for 5 minutes at room temperature and incubated overnight at 4°C with primary antibodies against CHI3L1 (R&D Systems, 1:500), MYOC (a kind gift from Dr. W. Daniel Stamer, Duke University, 1:3000), OCT4 (Cell Signaling Technology, Danvers, MA, USA; 1:1000), CTGF (Santa Cruz Biotechnology, 1:1000), α-SMA (R&D Systems, 1:1000), fibronectin (FN, Abcam, 1:1000), and GAPDH (Cell Signaling Technology, 1:2000).

    Techniques: Expressing, Staining, Western Blot, Control, Two Tailed Test

    LMS percentiles for urinary (a) KIM-1, (b, boys; c, girls) NGAL, (d, boys; e, girls) DKK3, and (f) CHI3L1 to creatinine ratios in the HARP cohort. The 5th, 10th, 25th (dashed line), 50th (bold line), 75th (dashed line), 90th, and 95th percentiles are given. Data on boys and girls is given as blue triangles and orange dots, respectively. CHI3L1, chitinase 3-like protein-1; crea, creatinine; DKK3, dickkopf-3; KIM-1, kidney-injury molecule-1; LMS, lambda-mu-sigma; NGAL, neutrophil gelatinase-associated lipocalin.

    Journal: Kidney International Reports

    Article Title: Kidney Injury Urine Biomarker Normal Ranges in Children

    doi: 10.1016/j.ekir.2026.106348

    Figure Lengend Snippet: LMS percentiles for urinary (a) KIM-1, (b, boys; c, girls) NGAL, (d, boys; e, girls) DKK3, and (f) CHI3L1 to creatinine ratios in the HARP cohort. The 5th, 10th, 25th (dashed line), 50th (bold line), 75th (dashed line), 90th, and 95th percentiles are given. Data on boys and girls is given as blue triangles and orange dots, respectively. CHI3L1, chitinase 3-like protein-1; crea, creatinine; DKK3, dickkopf-3; KIM-1, kidney-injury molecule-1; LMS, lambda-mu-sigma; NGAL, neutrophil gelatinase-associated lipocalin.

    Article Snippet: Urinary concentrations of KIM-1 (Quantikine ELISA, R&D system; MN Catalog No. DKM100; sensitivity 0.046 ng/ml), NGAL (Quantikine ELISA, R&D system; MN, Catalog No. DLCN20; sensitivity 0.04 ng/ml), DKK3 (Duo Set ELISA, R&D system; MN, Catalog No. DY1118, sensitivity 31.2 pg/ml), CHI3L1 (Quantikine ELISA, R&D system; MN, Catalog No. DC3L10; sensitivity 8.15 pg/ml), MCP-1 (Quantikine ELISA, R&D system;MN, Catalog No. DCP00; sensitivity 10 pg/ml), PIIINP (Novus Biologicals, Wiesbaden Nordenstadt, Germany, Catalog No. NBP2-76434; sensitivity 14.06 pg/ml), and EGF (Quantikine ELISA, R&D system; MN, Catalog No. DEG00; sensitivity 0.7 pg/ml) were measured using ELISA, according to the manufacturer’s protocols.

    Techniques: