Journal: Applied Microbiology and Biotechnology
Article Title: Aloin remodels the cell wall of Candida albicans to reduce its hyphal virulence against oral candidiasis
doi: 10.1007/s00253-025-13411-7
Figure Lengend Snippet: Aloin remodeled the cell wall of C. albicans . a PCA plots of the transcriptomes from C. albicans SC5314 exposed to 100 µg/mL aloin or equal amounts of DMSO as control. b Volcano plot illustrating differentially expressed genes in C. albicans SC5314 exposed to 100 µg/mL aloin relative to the control groups. Orange, blue, and gray dots represent upregulated, downregulated, and insignificantly changed genes, respectively. c GO analysis of differentially expressed genes in C. albicans exposed to 100 µg/mL aloin compared to the control group (top 30). The fungal-type cell wall was highlighted in a red line. d The heatmap of the differential expression of cell wall–related genes in C. albicans SC5314 treated with 100 µg/mL aloin relative to the control group. e Effects of aloin on chitin and β−1,3-glucan content of C. albicans cell walls. ** P < 0.01; **** P < 0.0001; ns, no significance. f The expressions of key genes related β−1,3-glucan biosynthesis were measured by RT-qPCR. * P < 0.05; ** P < 0.01; ns, no significance. g The combinational effects between micafungin and aloin. C. albicans SC5314 was treated with aloin alone (6.25 to 100 µg/mL), micafungin alone (0.016 to 0.25 µg/mL), and their combinations (micafungin ranged from 0.016 to 0.25 µg/mL with aloin at 100 µg/mL). Aloin significantly reduced the inhibitory effects of micafungin at 0.032 and 0.064 µg/mL
Article Snippet: Micafungin sodium (CAS 208538–73-2), itraconazole (CAS 84625–61-6), and 5-fluorocytosine (CAS 2022–85-7) were purchased from MCE (Monmouth Junction, NJ, USA).
Techniques: Control, Expressing, Quantitative RT-PCR
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