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aa92593  (MedChemExpress)


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    MedChemExpress aa92593
    Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor <t>AA92593</t> on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.
    Aa92593, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 94 stars, based on 3 article reviews
    aa92593 - by Bioz Stars, 2026-02
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    Images

    1) Product Images from "Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens"

    Article Title: Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

    Journal: Investigative Ophthalmology & Visual Science

    doi: 10.1167/iovs.66.1.3

    Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor AA92593 on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.
    Figure Legend Snippet: Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor AA92593 on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.

    Techniques Used: In Vitro, Expressing, Labeling, Two Tailed Test, MANN-WHITNEY



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    Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor <t>AA92593</t> on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.
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    Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor <t>AA92593</t> on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.
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    Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor <t>AA92593</t> on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.
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    Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor <t>AA92593</t> on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.
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    Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor AA92593 on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.

    Journal: Investigative Ophthalmology & Visual Science

    Article Title: Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens

    doi: 10.1167/iovs.66.1.3

    Figure Lengend Snippet: Both OPN4 and melatonin influence ER stress in chicken RGCs under BL in vitro. ( A ) Expression levels of genes associated with mitochondrial dynamics and damage in the retina following five weeks of monochromatic light treatment ( n = 5–9). ( B ) Fluorescent labeling of DNA fragmentation in chicken retinas. ( C ) Effects of light wavelength on the transcription levels of Opn4 orthologs in the chicken retina ( n = 5). ( D ) Protein levels of OPN4m in chicken retinas after five weeks of monochromatic light treatment ( n = 5). ( E ) BL exposure resulted in greater muscular pupil constriction in chickens ( n = 6). ( F , G ) BL exposure does not influence the kinetics of pupil contraction in chickens (one-phase association, n = 5). ( H ) Expression levels of melatonin-related proteins ( n = 5). ( I ) Localization of Mel1a in the chicken retina. ( J ) Localization of AANAT in the nuclei of RGCs ( n = 5). ( K ) Effects of the OPN4 inhibitor AA92593 on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( L ) Effects of melatonin on the viability of embryonic chicken retinal cells ( n = 4). The black arrows indicate the drug concentrations used in vitro. ( M , N ) Effects of the in vitro addition of AA92593 and melatonin on the intensity of p -PERK immune-positive signals in TUJ-1 + embryonic chicken retinal cells under BL ( n = 5). Data were presented as means ± SEM. The results were analyzed using the Kruskal-Wallis test with Dunn's multiple comparisons ( A ) or one-way ANOVA with Sidak's multiple comparisons tests ( C , D , E , H , and J ). Comparisons between drugs and their solvents were conducted using an unpaired two-tailed Student's t -test or Mann-Whitney U test ( K , L , and N ); * P < 0.05, ** P < 0.01, and **** P < 0.0001. Dnm1, dynamin 1; Opa1, optic atrophy 1; Mfn1, mitofusin-1; Mfn2, mitofusin-2; cgas, cyclic guanosine monophosphate (GMP)-AMP synthase; Sting, stimulator of interferon genes; Mel1b, melatonin receptor 2; NQO2, quinone dehydrogenase 2; Mel, melatonin.

    Article Snippet: During the experiments, DMSO (0.1%), AA92593 (HY-125145; MedChemExpress, Monmouth Junction, NJ, USA), melatonin (HY-B0075; MedChemExpress), or a combination of AA92593 and melatonin was added 30 minutes before light treatment.

    Techniques: In Vitro, Expressing, Labeling, Two Tailed Test, MANN-WHITNEY