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methylmalonate  (MedChemExpress)


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    Structured Review

    MedChemExpress methylmalonate
    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    Methylmalonate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/methylmalonate/product/MedChemExpress
    Average 94 stars, based on 3 article reviews
    methylmalonate - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis"

    Article Title: An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis

    Journal: Cell Genomics

    doi: 10.1016/j.xgen.2025.100855

    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    Figure Legend Snippet: ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .

    Techniques Used: Control, Over Expression, CRISPR, Knock-Out, Labeling, Flux Assay, Two Tailed Test



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    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
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    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
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    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
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    Image Search Results


    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .

    Journal: Cell Genomics

    Article Title: An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis

    doi: 10.1016/j.xgen.2025.100855

    Figure Lengend Snippet: ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .

    Article Snippet: Methylmalonate , MedChemExpress , Cat# 516-05-2.

    Techniques: Control, Over Expression, CRISPR, Knock-Out, Labeling, Flux Assay, Two Tailed Test