Review



methylmalonate  (MedChemExpress)


Bioz Verified Symbol MedChemExpress is a verified supplier
Bioz Manufacturer Symbol MedChemExpress manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 94
      Buy from Supplier

    Structured Review

    MedChemExpress methylmalonate
    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    Methylmalonate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/methylmalonate/product/MedChemExpress
    Average 94 stars, based on 3 article reviews
    methylmalonate - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis"

    Article Title: An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis

    Journal: Cell Genomics

    doi: 10.1016/j.xgen.2025.100855

    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    Figure Legend Snippet: ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .

    Techniques Used: Control, Over Expression, CRISPR, Knock-Out, Labeling, Flux Assay, Two Tailed Test



    Similar Products

    methylmalonate  (MedChemExpress)
    94
    MedChemExpress methylmalonate
    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    Methylmalonate, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/methylmalonate/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    methylmalonate - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier
    13c4 methylmalonic acid  (Millipore)
    90
    Millipore 13c4 methylmalonic acid
    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    13c4 Methylmalonic Acid, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/13c4 methylmalonic acid/product/Millipore
    Average 90 stars, based on 1 article reviews
    13c4 methylmalonic acid - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    methylmalonic aciduria with homocystinuria  (5 PRIME)
    90
    5 PRIME methylmalonic aciduria with homocystinuria
    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    Methylmalonic Aciduria With Homocystinuria, supplied by 5 PRIME, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/methylmalonic aciduria with homocystinuria/product/5 PRIME
    Average 90 stars, based on 1 article reviews
    methylmalonic aciduria with homocystinuria - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    d4902 methylmalonate medchemexpress  (MedChemExpress)
    94
    MedChemExpress d4902 methylmalonate medchemexpress
    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    D4902 Methylmalonate Medchemexpress, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/d4902 methylmalonate medchemexpress/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    d4902 methylmalonate medchemexpress - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier
    bis[(12-crown-4)methyl]-2-dodecyl-2-methylmalonate 1  (Dojindo Labs)
    90
    Dojindo Labs bis[(12-crown-4)methyl]-2-dodecyl-2-methylmalonate 1
    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    Bis[(12 Crown 4)Methyl] 2 Dodecyl 2 Methylmalonate 1, supplied by Dojindo Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bis[(12-crown-4)methyl]-2-dodecyl-2-methylmalonate 1/product/Dojindo Labs
    Average 90 stars, based on 1 article reviews
    bis[(12-crown-4)methyl]-2-dodecyl-2-methylmalonate 1 - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    methylmalonic acid elisa kit  (Abbexa Ltd)
    90
    Abbexa Ltd methylmalonic acid elisa kit
    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of <t>methylmalonate</t> (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .
    Methylmalonic Acid Elisa Kit, supplied by Abbexa Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/methylmalonic acid elisa kit/product/Abbexa Ltd
    Average 90 stars, based on 1 article reviews
    methylmalonic acid elisa kit - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    methylmalonic acid thermofisher  (Thermo Fisher)
    90
    Thermo Fisher methylmalonic acid thermofisher

    Methylmalonic Acid Thermofisher, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/methylmalonic acid thermofisher/product/Thermo Fisher
    Average 90 stars, based on 1 article reviews
    methylmalonic acid thermofisher - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier
    pan methylmalonic acid  (Cell Signaling Technology Inc)
    95
    Cell Signaling Technology Inc pan methylmalonic acid

    Pan Methylmalonic Acid, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pan methylmalonic acid/product/Cell Signaling Technology Inc
    Average 95 stars, based on 1 article reviews
    pan methylmalonic acid - by Bioz Stars, 2026-02
    95/100 stars
    		  Buy from Supplier
    mma  (MedChemExpress)
    94
    MedChemExpress mma

    Mma, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mma/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    mma - by Bioz Stars, 2026-02
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .

    Journal: Cell Genomics

    Article Title: An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis

    doi: 10.1016/j.xgen.2025.100855

    Figure Lengend Snippet: ACSF3 regulates mitochondrial activities by controlling the catabolism of threonine to MMA (A and B) Relative abundance of methylmalonate (A) and respiratory rates (B) in hepatocytes. CON, control; OE, adenovirus-based Acsf3 overexpression; MMA, methylmalonic acid. n = 5. (C) Establishment of the Acsf3 −/− mouse model using CRISPR-Cas9 technology, in which exons 2–5 were depleted. (D) Relative abundance of MMA in serum, urine, hepatocytes, and liver and relative abundance of MMA and succinyl-CoA in the liver. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (E) Respiratory rates in hepatocytes. MMA, 5 mM methylmalonate. N = 3. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 2–3. (F) Images and relative AR-S intensity induced by differentiated medium in C3H10. CON, control. MMA: methylmalonic acid. Scale bar, 100 μm. n = 5. (G) Potential metabolic pathway of MMA based on the literature. (H) Relative abundance of MMA in the serum of mice administered a ketogenic diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ); Keto, ketogenic diet. n = 3. (I) Relative abundance of threonine and MMA in mice administered a ketogenic diet and threonine in drinking water. KO, knockout mice ( Acsf3 −/− ). n = 3. (J) Relative abundance of MMA in the serum of mice administered a low-threonine diet. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. (K) Schematic of a 13 C-labeled threonine-based metabolic flux assay. (L) Relative abundance of 13 C-labeled MMA-CoA in hepatocytes. CON, control mice ( Acsf3 +/− ); KO, knockout mice ( Acsf3 −/− ). n = 4. Data are shown as mean ± SEM. Data analyses were conducted by two-tailed t test except where noted otherwise. See also .

    Article Snippet: Methylmalonate , MedChemExpress , Cat# 516-05-2.

    Techniques: Control, Over Expression, CRISPR, Knock-Out, Labeling, Flux Assay, Two Tailed Test

    Journal: iScience

    Article Title: Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy

    doi: 10.1016/j.isci.2025.111957

    Figure Lengend Snippet:

    Article Snippet: Methylmalonic acid (MMA) , ThermoFisher , Cat#: 127090050.

    Techniques: Recombinant, Synthesized, Selection, Enzyme-linked Immunosorbent Assay, Mass Spectrometry, Software