precursor fapi 46 (MedChemExpress)
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precursor fapi 46
Precursor Fapi 46, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fapi+precursor+(fapi-46/FAPI-46/10__1002_slash_bkcs__70104-31-1-5
Average 94 stars, based on 10 article reviews
Precursor Fapi 46, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fapi+precursor+(fapi-46/FAPI-46/10__1002_slash_bkcs__70104-31-1-5
Average 94 stars, based on 10 article reviews
precursor fapi 46 - by Bioz Stars,
2026-11
94/100 stars
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Activation Assay:Article Title: Cytotoxicity and cell cycle changes in prostate cancer cells with differing PSMA expression and p53 status after treatment with PSMA-targeting radioligand [ 212 Pb]Pb-AB001. Article Snippet: .. The 212Pb was used for the radiolabelling of the PSMA ligand AB001 (Medkoo Biosciences, Morrisville, NC, US), as described by Stenberg et al.29 Article Title: Cytotoxicity and cell cycle changes in prostate cancer cells with differing PSMA expression and p53 status after treatment with PSMA-targeting radioligand [ 212 Pb]Pb-AB001 Article Snippet: .. The 212 Pb was used for the radiolabelling of the PSMA ligand AB001 (Medkoo Biosciences, Morrisville, NC, US), as described by Stenberg et al. Article Title: Radiobiological investigations of a [ 212 Pb]Pb-carbonic anhydrase IX-targeting small-molecule ligand in renal cell carcinoma and colorectal cancer models. Article Snippet: Purpose: Carbonic anhydrase IX (CAIX), overexpressed in multiple cancers but limited in normal tissue, is a promising target for radionuclide therapy.. This study evaluates [212Pb]Pb-MKV-509, a novel DOTA-conjugated small-molecule ligand, for CAIX-targeted alpha therapy in preclinical renal carcinoma (SK-RC-52) and colorectal (HT-29) cancer models.. Materials and methods: [212Pb]Pb-MKV-509 was assessed for radiochemical purity and stability. Negative Control:Article Title: Cytotoxicity and cell cycle changes in prostate cancer cells with differing PSMA expression and p53 status after treatment with PSMA-targeting radioligand [ 212 Pb]Pb-AB001. Article Snippet: .. The 212Pb was used for the radiolabelling of the PSMA ligand AB001 (Medkoo Biosciences, Morrisville, NC, US), as described by Stenberg et al.29 Article Title: Cytotoxicity and cell cycle changes in prostate cancer cells with differing PSMA expression and p53 status after treatment with PSMA-targeting radioligand [ 212 Pb]Pb-AB001 Article Snippet: .. The 212 Pb was used for the radiolabelling of the PSMA ligand AB001 (Medkoo Biosciences, Morrisville, NC, US), as described by Stenberg et al. Article Title: Radiobiological investigations of a [ 212 Pb]Pb-carbonic anhydrase IX-targeting small-molecule ligand in renal cell carcinoma and colorectal cancer models. Article Snippet: Purpose: Carbonic anhydrase IX (CAIX), overexpressed in multiple cancers but limited in normal tissue, is a promising target for radionuclide therapy.. This study evaluates [212Pb]Pb-MKV-509, a novel DOTA-conjugated small-molecule ligand, for CAIX-targeted alpha therapy in preclinical renal carcinoma (SK-RC-52) and colorectal (HT-29) cancer models.. Materials and methods: [212Pb]Pb-MKV-509 was assessed for radiochemical purity and stability. Radioactivity:Article Title: [ 68 Ga]Ga-FAPI-46 synthesis on a GAIA® module system: Thorough study of the automated radiolabeling reaction conditions. Article Snippet: .. Article Title: Bridging Research and Clinical Practice: Automated [ 68 Ga]Ga-FAPi-46 Synthesis and Quality Control for Oncological PET Imaging Article Snippet: .. The Injection:Article Title: Feasibility of [
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Ga
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]
<scp>FAPI</scp>
‐46
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for assessing fibroinflammatory remodeling in experimental chronic colitis Article Snippet: [68Ga]FAPI-46 was synthesized by adapting previously reported methods with minor modifications.15 Briefly, a 68Ge/68Ga generator (Eckert & Ziegler, Germany) was eluted with 0.1 M HCl through a 0.22 μm GV sterile filter into a sterile collection vial under aseptic conditions. .. The |
![Radiochemical stability assessment of [ 68 <t>Ga]Ga-FAPi-46</t> in ( A ) saline solution (room temperature) and ( B ) human serum (37 °C), assessed through ascending chromatography. Data are expressed as ‘mean ± SD’ ( n = 3–4). No statistically significant difference was observed within the time interval for the radiochemical stability in saline solution ( p = 0.1758) and human serum ( p = 0.8388). ANOVA was conducted, followed by Tukey’s multiple comparisons test.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_9493/pmc13119493/pmc13119493__pharmaceuticals-19-00594-g003.jpg)
![RP-HPLC chromatographic profiles: ( A ) Free [ 68 Ga]GaCl 3 and the unlabeled FAPi-46 precursor; ( B ) [ 68 Ga]Ga-FAPi-46 evaluated at different time points after radiolabeling (radiochemical stability).](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_9493/pmc13119493/pmc13119493__pharmaceuticals-19-00594-g004.jpg)
![[ 68 Ga]Ga-FAPi-46 and [ 18 F]FDG PET/CT of a 50-year-old woman with lung adenocarcinoma for initial staging. ( A – G ): [ 68 Ga]Ga-FAPi-46 PET/CT. ( H – N ): [ 18 F]FDG PET/CT. ( A , H ): Maximum intensity projection (anterior view). ( D – G ): [ 68 Ga]Ga-FAPi-46 PET/CT and ( K – N ): [ 18 F]FDG PET/CT axial fusion images. PET/CT shows intense uptake of both ( E ) [ 68 Ga]Ga-FAPi-46 and ( L ) [ 18 F]FDG in the primary tumor in the right lung (green arrows). Tracer uptake is also observed in ipsilateral pulmonary hilum and subcarinal lymph nodes metastases (pink circles and arrows) and in a right supraclavicular lymph node metastasis (yellow arrow). Of note, PET/CT with [ 68 Ga]Ga-FAPi-46 showed greater degree of uptake in mediastinal and supraclavicular lymph nodes ( F , G , D ) in comparison to [ 18 F]FDG ( M , N , K ). A nodular lesion in central nervous system shown on head MRI (( J ), red arrow) is shown on PET/CT with [ 68 Ga]Ga-FAPi-46 (( B , C ), red arrows) but is not identified on [ 18 F]FDG PET/CT ( I ). Thyroid uptake due to thyroiditis (blue arrow) is observed in [ 18 F]FDG PET/CT ( K ) but not in [ 68 Ga]Ga-FAPi-46 images ( D ).](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_9493/pmc13119493/pmc13119493__pharmaceuticals-19-00594-g005.jpg)
![Schematic representation of the automated synthesis and purification process for [ 68 Ga]Ga-FAPi-46. Adapted from NIAID NIH BioArt Source .](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_9493/pmc13119493/pmc13119493__pharmaceuticals-19-00594-g006.jpg)