hypoxia chamber (BioSpherix)

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BioSpherix hypoxia chamber
Hypoxia Chamber, supplied by BioSpherix, used in various techniques. Bioz Stars score: 96/100, based on 235 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/c21/ProOx+C21/pmc13033950-45-8-10
Average 96 stars, based on 235 article reviews

hypoxia chamber - by Bioz Stars, 2026-10

96/100 stars

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Article Title: Metformin protects against myocardial ischemia/reperfusion injury and suppresses the Nur77-SPARCL1 inflammatory axis.
Article Snippet: Myocardial ischemia/reperfusion (I/R) injury triggers sterile inflammation that amplifies tissue damage.. We investigated whether metformin limits this response through the Nur77–SPARCL1 axis.. RNA sequencing of HL-1 cardiomyocytes (n = 3 biological replicates per group) identified Sparcl1 as a metformin-responsive transcript.

Article Title: Immune‐Responsive Bioinks Enable Vision‐Guided in Situ Robotic Bioprinting to Accelerate Diabetic Wound Healing
Article Snippet: Chronic diabetic wounds remain amajor clinical challenge because persistent inflammation, hypoxia, and immune dysregulation prevent the transition of macrophages from pro-inflammatory M1 states to pro-regenerative M2 phenotypes.. Here, we report an immunomodulatory colloidal bioink that integrates zein-based oxygen-generating microparticles and human mesenchymal stem cells within a porous, mechanically robust matrix for adaptive in situ bioprinting.. Implemented with the autonomous, intelligent, visually guided in situ robotic bioprinting platform, this bioink enables patient-specific deposition directly onto wound defects with high spatial conformity and stable tissue integration.

Article Title: Direct interaction between miR-210-5p and HIF-1α regulates HIF-dependent transcription
Article Snippet: Hypoxic stimulation was performed at 1% O2, 5% CO2, and 94% N2 using a ProOx C21 hypoxia chamber (BioSpherix).

Article Title: Female metabolic resilience and male-biased protein quality defects under hypoxia in human brain organoids
Article Snippet: COs were exposed to low oxygen conditions on day 120 employing a hypoxic chamber (C-Chamber Three Shelf, Biospherix) and an oxygen controller (Pro Ox C21 Oxygen CO2 Single Chamber Controller).

Article Title: Female metabolic resilience and male-biased protein quality defects under hypoxic in human brain organoids
Article Snippet: 611 Hypoxia modelling 612 613 COs were exposed to low oxygen conditions on day 120 employing a hypoxic chamber (C-Chamber 614 Three Shelf, Biospherix) and an oxygen controller (Pro Ox C21 Oxygen CO2 Single Chamber 615 Controller).

Cell Culture:

Article Title: EPAS1 knockdown is associated with cell cycle and DNA replication programs and MYC/E2F-related signatures in hemangioma endothelial cells
Article Snippet: .. Cells were cultured under normoxic (21% O2, 5% CO2) or hypoxic (1% O2, 5% CO2, 94% N2) conditions in CO2 incubators (Thermo Fisher), with hypoxia maintained using a ProOx C21 O2 controller (BioSpherix). ..

Incubator:

Article Title: TH1834-Mediated TIP60 Inhibition Protects Against Ischemia/Reperfusion Damage in Human iPSC-Derived Cardiomyocytes and Cardioids
Article Snippet: .. H/R injury was induced using a hypoxia incubator (Biospherix, ProOX C21) with continuous oxygen monitoring. ..

Control:

Article Title: Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing.
Article Snippet: Slices were subsequently cultured in liver tissue culture medium composed of William’s Medium E (WME) with L-glutamine (Thermo Fisher Scientific, Cat# A1217601), supplemented with D-glucose (14 m M ; Sigma– Aldrich, Cat# G8 769), penicillin (100 U/mL) and streptomycin (100 μg/mL; Gibco, Cat# 15140122), insulin (30 n M ; Sigma– Aldrich, Cat# I9278), glucagon (100 n M ; Sigma–Aldrich, Cat# G2044), corticosterone (1 μM ; Sigma–Aldrich, Cat# C2505), epidermal growth factor (EGF, 1 n M ; PeproTech, Cat# AF-100-15), and human AB serum (5%; Sigma–Aldrich, Cat# H4522). .. All experiments under controlled oxygen conditions were conducted in an O2 /CO2 control chamber (ProOx Model C21; BioSpherix). .. Tisue cores were obtained using a 6-mm Stiefel biopsy punch, transerred to a metal mold, embedded in 3% low-gelling-temperature garose, and placed on ice for 2–5 min. Agarose-embedded cores ere sectioned using a Leica VT1200S vibrating blade vibratome t a speed of 0.3 mm/s, amplitude of 1.3 mm, and thickness anging from 150 to 350 μm.

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