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y27632  (MedChemExpress)


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    Structured Review

    MedChemExpress y27632
    Y27632, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 714 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/y27632/Y-27632/pm42435365-56-10-11
    Average 99 stars, based on 714 article reviews
    y27632 - by Bioz Stars, 2026-09
    99/100 stars

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    Related Articles

    Formulation:

    Article Title: Culture medium and culture method for primary cells of intestinal cancer
    Article Snippet: .. The formulation of Basic Medium is: DMEM/F12 medium (purchased from Corning)+5 μM Y27632 (purchased from MCE)+5% (v/v) fetal bovine serum (purchased from Excell Bio)+100 μg/mL Primocin (purchased from InvivoGen, 0.2% (v/v), the concentration of commercial product is 50 mg/ml). ..

    Concentration Assay:

    Article Title: Culture medium and culture method for primary cells of intestinal cancer
    Article Snippet: .. The formulation of Basic Medium is: DMEM/F12 medium (purchased from Corning)+5 μM Y27632 (purchased from MCE)+5% (v/v) fetal bovine serum (purchased from Excell Bio)+100 μg/mL Primocin (purchased from InvivoGen, 0.2% (v/v), the concentration of commercial product is 50 mg/ml). ..

    Passaging:

    Article Title: Development of compact transcriptional effectors using high-throughput measurements in diverse contexts
    Article Snippet: WTC11 (Gladstone Institute) human iPSCs were cultured in mTeSR Plus medium (STEMCELL Technologies) and cultured on Geltrex-coated plates (Gibco). .. Cells were routinely passaged at approximately 80% confluency by enzymatic lifting with Accutase (Innovative Cell Technologies), and media was supplemented with 10 μM Y27632 (MedChemExpress) for the first 24 h after passaging. .. Primary CD8 + T cells were isolated using the EasySep Human CD8 + T cell Isolation Kit (STEMCELL Technologies) from the whole peripheral blood provided by healthy donors at the Blood Donor Center at Boston Children’s Hospital through a protocol approved by the Boston University Institutional Review Board.

    Suspension:

    Article Title: Robust generation of distal respiratory airway organoids by an engineered cuboid chip.
    Article Snippet: Generation of LPCs For differentiation into lung progenitor cells (LPCs), hPSCs line H1 (passage 25-40) were first dissociated into single cells using Accutase (StemCell Technologies, 07920). .. The resulting cell suspension was resuspended in mTeSR1 medium containing 10 μM Y27632 (MCE, HY10071), and counted using an automated cell counter (HUAPO APCFcount300) with Trypan blue (Gibco; 1:1 ratio) for viability assessment. ..



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    Image Search Results


    Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.

    Journal: Bioactive Materials

    Article Title: Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores

    doi: 10.1016/j.bioactmat.2026.02.005

    Figure Lengend Snippet: Cell-substrate adhesion characteristics control cell spanning. (a) Representative microscopy images for fibroblasts adhered to a soft substrate, stimulated with CN03 (RhoA activator), Y27632 (ROCK inhibitor), PF228 (Focal adhesion kinase inhibitor), and MMC (DNA crosslinking). (b) Cell length for the distinct modulators and (c) FSD compared to the fibroblasts (dash-dotted reference line indicates the median value). (d) Relationship between probability of spanning cells and cylinder diameter for the selected cell types. (e) Correlation between cell length and probability of cells spanning. (f) Correlation between FSD and probability of cells spanning. In red, allometric fit, given by y = a x b . (g, left) Schematic representation of the boundary conditions ( U, UR indicating translational and rotational degrees of freedom respectively) and material properties of the FE model representing an individual cell with two adhesion morphologies (C1 = fully adherent, circular morphology, C2 = large FSD, polar morphology) attached to cylindrical surfaces with Ø = 100 and 1000 μm. (g, middle) Resulting cell displacement according to the cell adhesion morphology (C1, C2) on a cylinder with Ø = 100 μm and (g, right) on a cylinder with Ø = 1000 μm in isometric view (top row) and front view (bottom row). Vector plot is combined with deformed shape to better visualize the direction and magnitude of the displacement. Statistical significance via Mann-Whitney test (two sided) with Bonferroni correction, ∗p < 0.05. N ≥ 60 cells/cell type for FA and morphological analysis. N ≥ 3 GeoChips/cell type for a total of N ≥ 12 half-cylinders/condition. 1 donor/cell type. Scale bar 50 μm.

    Article Snippet: Y27632 (13624, Cell Signaling Technology, Inc.) was supplemented to the medium at a concentration of 10 μM, CN03 (Rho Activator II, Cytoskeleton, Inc.) was used at a concentration of 5 μg/ml, and PF228 (PZ0117, Sigma-Aldrich) was supplemented at a concentration of 100 μM.

    Techniques: Control, Microscopy, Plasmid Preparation, MANN-WHITNEY