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vs5584  (MedChemExpress)


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    MedChemExpress vs5584
    Vs5584, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/vs5584/product/MedChemExpress
    Average 91 stars, based on 2 article reviews
    vs5584 - by Bioz Stars, 2026-02
    91/100 stars

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    vs5584  (MedChemExpress)
    91
    MedChemExpress vs5584
    Vs5584, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/vs5584/product/MedChemExpress
    Average 91 stars, based on 1 article reviews
    vs5584 - by Bioz Stars, 2026-02
    91/100 stars
    		  Buy from Supplier
    vs5584  (Selleck Chemicals)
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    Selleck Chemicals vs5584
    Fig. 6. CCT128930 enhanced the anticancer effect of <t>VS5584</t> in human osteosarcoma cells. (A) Combined inhibitory effect of CCT128930 and VS5584 on U2OS cells. U2OS cells were co-treated with 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Cell inhibitory rate was detected by CCK-8 assay. (B) CCT128930 enhanced VS5584-induced early apoptosis in human osteosarcoma cells. U2OS cells were exposed to 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Then, cells were stained by Annexin-V/PI, and examined by a fluorescence microscope. Apoptotic cells were calculated by counting annexin-positive cells. (C) Cells apoptosis imaged by fluorescence microscope. CCT128930 enhanced VS5584-induced PARP cleavage and caspase activation in U2OS (D) and MG-63 (E) cells. U2OS cells or MG-63 cells were exposed to 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Protein expression was detected through western blotting method. Bars with different letters indicate the statistical significance at P < 0.05.
    Vs5584, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/vs5584/product/Selleck Chemicals
    Average 92 stars, based on 1 article reviews
    vs5584 - by Bioz Stars, 2026-02
    92/100 stars
    		  Buy from Supplier

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    Fig. 6. CCT128930 enhanced the anticancer effect of VS5584 in human osteosarcoma cells. (A) Combined inhibitory effect of CCT128930 and VS5584 on U2OS cells. U2OS cells were co-treated with 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Cell inhibitory rate was detected by CCK-8 assay. (B) CCT128930 enhanced VS5584-induced early apoptosis in human osteosarcoma cells. U2OS cells were exposed to 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Then, cells were stained by Annexin-V/PI, and examined by a fluorescence microscope. Apoptotic cells were calculated by counting annexin-positive cells. (C) Cells apoptosis imaged by fluorescence microscope. CCT128930 enhanced VS5584-induced PARP cleavage and caspase activation in U2OS (D) and MG-63 (E) cells. U2OS cells or MG-63 cells were exposed to 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Protein expression was detected through western blotting method. Bars with different letters indicate the statistical significance at P < 0.05.

    Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    Article Title: CCT128930 induces G1-phase arrest and apoptosis and synergistically enhances the anticancer efficiency of VS5584 in human osteosarcoma cells.

    doi: 10.1016/j.biopha.2020.110544

    Figure Lengend Snippet: Fig. 6. CCT128930 enhanced the anticancer effect of VS5584 in human osteosarcoma cells. (A) Combined inhibitory effect of CCT128930 and VS5584 on U2OS cells. U2OS cells were co-treated with 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Cell inhibitory rate was detected by CCK-8 assay. (B) CCT128930 enhanced VS5584-induced early apoptosis in human osteosarcoma cells. U2OS cells were exposed to 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Then, cells were stained by Annexin-V/PI, and examined by a fluorescence microscope. Apoptotic cells were calculated by counting annexin-positive cells. (C) Cells apoptosis imaged by fluorescence microscope. CCT128930 enhanced VS5584-induced PARP cleavage and caspase activation in U2OS (D) and MG-63 (E) cells. U2OS cells or MG-63 cells were exposed to 5 μM CCT128930 or/and 5 μM VS5584 for 24 h. Protein expression was detected through western blotting method. Bars with different letters indicate the statistical significance at P < 0.05.

    Article Snippet: CCT128930 (#885499-61-6) and VS5584 (1246560-33-7) were obtained from Selleck (Shanghai, China).

    Techniques: CCK-8 Assay, Staining, Microscopy, Activation Assay, Expressing, Western Blot