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Philips Healthcare uvb lamps
The extraction process and proposed mechanisms for GPEVs in treating <t>UVB-induced</t> Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. <t>UVB</t> <t>radiation</t> triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.
Uvb Lamps, supplied by Philips Healthcare, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Article Title: Gynostemma pentaphyllum -derived extracellular vesicles alleviate skin aging by destabilizing STING

Journal: Bioactive Materials

doi: 10.1016/j.bioactmat.2026.03.010

The extraction process and proposed mechanisms for GPEVs in treating UVB-induced Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. UVB radiation triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.
Figure Legend Snippet: The extraction process and proposed mechanisms for GPEVs in treating UVB-induced Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. UVB radiation triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.

Techniques Used: Extraction, Derivative Assay, Isolation, Purification

Related Articles

other:

Article Title: The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging.
Article Snippet: UVB was supplied by Philips (China).

Article Title: Aloe Kanti, a natural anti-aging gel, modulates exogenous insult- and aging-induced aberrations in keratinocytes, dermal fibroblasts, melanocytes, and protects Caenorhabditis elegans from UVB photoaging.
Article Snippet: Chronological aging, exposure to ultraviolet radiation, and various environmental insults deteriorate structure and function of skin.. Lack of proper skincare further augments skin aging and related disorders.. The objective of current study was to investigate phytochemical composition and bioactivity of Aloe Kanti (Aloe K), an Aloe verabased topical herbal skincare gel formulation.

Article Title: Mechanically regulated microcarriers with stem cell loading for skin photoaging therapy
Article Snippet: In photoaging model experiment, the dorsal skin of nude mice (6–8 weeks old) was exposed to UVB (Philips; emission spectrum 311 nm) positioned 15 cm above and MOP-8 (0.1 mg/ml) every other day for eight weeks.

Irradiation:

Article Title: Milk-derived exosome-loaded SS31 as a novel strategy to mitigate UV-induced photodamage in skin
Article Snippet: It is widely recognized that ultraviolet (UV) radiation primarily catalyses photodamage in the skin by generating reactive oxygen species (ROS).. In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.. Our findings indicate that Exo-SS31 is an effective antioxidant capable of mitigating Human dermal fibroblast (HDF) damage induced by ultraviolet exposure, suppressing ROS production, and achieving greater therapeutic efficacy than SS31 alone.

Article Title: Pickering emulsion of lavender essential oil stabilized by the sodium starch octenyl succinate-hyaluronic acid complex for skin photodamage prevention.
Article Snippet: Preventing ultraviolet (UV) radiation is crucial for protecting the skin barrier and delaying skin photoaging.. Lavender essential oil (LEO) possesses antioxidant and skin barrier–protective effects; however, its application is constrained by volatility.. This study aimed to develop a LEO Pickering emulsion (LEOPE) stabilized by sodium starch octenyl succinate–hyaluronic acid (SSOS–HA) and apply it to protect the skin from UV-induced damage.

Article Title: Andrographolide analogues are agonists of the estrogen receptor alpha in vitro and in vivo.
Article Snippet: Estrogen mediates diverse physiological and pathological processes through estrogen receptors (ERα and ERβ).. Andrographolide analogues have broad pharmacological effects including anti-inflammation and antimicrobial, antiviral, and hepatoprotective activity.. However, the direct targets of these andrographolide analogues are not clear yet.

Activation Assay:

Article Title: Qualitative and quantitative analysis of colorimetric response in different UV solar radiation level indicator bracelets based on photochromic substances
Article Snippet: .. When photochromic devices were exposed to only UVB (exposure under 5.8Wm-2 of a narrow Band UVB phototherapy lamp (Philips PL-S 9 W/01, Philips, Netherlands) with a peak at 311 nm), only faint activation was observed after 120 s (data not shown). ..

Saline:

Article Title: A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9 + Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive Autoimmunity
Article Snippet: .. The cells were washed once with phosphate-buffered saline (PBS, pH 7.4) before being exposed to the indicated dose of UVB (50 mj/cm 2 or 100 mj/cm 2 ) using a SolRx 100-Series Handheld device equipped with fluorescent bulbs (285–350 nm, Philips PL S 9W/12/2P, Solar System, Canada). ..



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The extraction process and proposed mechanisms for GPEVs in treating <t>UVB-induced</t> Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. <t>UVB</t> <t>radiation</t> triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.
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The extraction process and proposed mechanisms for GPEVs in treating <t>UVB-induced</t> Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. <t>UVB</t> <t>radiation</t> triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.
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The extraction process and proposed mechanisms for GPEVs in treating <t>UVB-induced</t> Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. <t>UVB</t> <t>radiation</t> triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.
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The extraction process and proposed mechanisms for GPEVs in treating UVB-induced Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. UVB radiation triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.

Journal: Bioactive Materials

Article Title: Gynostemma pentaphyllum -derived extracellular vesicles alleviate skin aging by destabilizing STING

doi: 10.1016/j.bioactmat.2026.03.010

Figure Lengend Snippet: The extraction process and proposed mechanisms for GPEVs in treating UVB-induced Skin aging. Extracellular vesicles derived from Gynostemma pentaphyllum (GPEVs), isolated and purified from fresh whole herb via differential ultracentrifugation, exhibit anti-photoaging properties. UVB radiation triggers the up-regulation of STING, activating the TBK1-CTCF pathway and causing photoaging. GPEVs effectively promote STING degradation, reducing CTCF-mediated aging gene transcription, protecting against UVB-induced skin aging.

Article Snippet: The UVB radiation source consists of four UVB lamps (Philips, Shanghai, China) with a peak intensity at 311 nm.

Techniques: Extraction, Derivative Assay, Isolation, Purification