Journal: Nanoscale Advances
Article Title: Bis-prodrug cryopreserved lipid nanoparticles with enzymatically triggered release
doi: 10.1039/d5na00675a
Figure Lengend Snippet: Effect of cryoprotectant concentration and surfactant composition on appearance of the formulations after freeze–drying and after redispersion samples were freeze-dried on Day 2 after formulation. (A) Photos of each formulation's cake once freeze-dried with different concentrations of cryoprotectant (sucrose) as well as surfactant composition. (B) Photos of each of the same formulation before and after lyophilization. (C) Z-average diameter, and PDI obtained by DLS. All formulations contained tricaprin at 14 wt% with varied in pegylated/unpegylated lipid surfactant blends on a mass ratio. Measurements made at a fixed position of 4.65 mm in the DLS at ∼0.58 mg mL −1 excluding sucrose.
Article Snippet: Tricaprin was purchased from Tokyo chemical industry and used as received.
Techniques: Concentration Assay, Formulation, Lyophilization