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topotecan hydrochloride tpt  (MedChemExpress)


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    MedChemExpress topotecan hydrochloride tpt
    Topotecan Hydrochloride Tpt, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/topotecan/Topotecan+hydrochloride/pm42261811-317-0-6
    Average 94 stars, based on 26 article reviews
    topotecan hydrochloride tpt - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Cell Counting:

    Article Title: Inhibition of ABCG2 by SCO-101 Enhances Chemotherapy Efficacy in Cancer
    Article Snippet: DMSO (cat#D2650-100), SN-38 (cat#H0165), Ko-143 (cat#K2144), Hoechst 33342 (cat#14533), PSC833 (cat#SML0572), MTT reagent (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (cat#475989), and Crystal Violet solution (cat#HT90132-1L) were purchased from Sigma-Aldrich/Merck (Burlington, MA, USA). .. Topotecan (catHY-13768A), pevonedistat (cat#HY-70062), mitoxantrone (cat#HY-13502A), and Cell counting kit 8 assay (CCK-8 assay; cat#HY-K0301) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). .. Zosuquidar (ZSQ, cat#LY335979) was purchased from Selleck Chemicals (Munich, DE, Germany).

    CCK-8 Assay:

    Article Title: Inhibition of ABCG2 by SCO-101 Enhances Chemotherapy Efficacy in Cancer
    Article Snippet: DMSO (cat#D2650-100), SN-38 (cat#H0165), Ko-143 (cat#K2144), Hoechst 33342 (cat#14533), PSC833 (cat#SML0572), MTT reagent (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (cat#475989), and Crystal Violet solution (cat#HT90132-1L) were purchased from Sigma-Aldrich/Merck (Burlington, MA, USA). .. Topotecan (catHY-13768A), pevonedistat (cat#HY-70062), mitoxantrone (cat#HY-13502A), and Cell counting kit 8 assay (CCK-8 assay; cat#HY-K0301) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). .. Zosuquidar (ZSQ, cat#LY335979) was purchased from Selleck Chemicals (Munich, DE, Germany).

    other:

    Article Title: Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death
    Article Snippet: Cas9 nickase or Cas9 nuclease mRNA was prepared in resuspension buffer R supplemented with RNasin Plus (40 U, Promega, #N2615) at the desired concentration in which to resuspend the cells for electroporation.

    Article Title: KSQ‐4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1‐Mediated Multidrug Resistant Cancers
    Article Snippet: Doxorubicin (HY‐15142A), paclitaxel (HY‐B0015), vincristine (HY‐N0488), topotecan (HY‐13768), and verapamil (HY‐14275) were from supplier of MedChem Express (Monmouth Junction, NJ, USA).



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    Image Search Results


    Schematic representation of casting of the topotecan-loaded MSP. MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Schematic representation of casting of the topotecan-loaded MSP. MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques:

    Representative digital images of the master mold (A) , PDMS mold (B) , and stereomicroscopic images of the topotecan MSP at different magnifications (C and D) , scanning electron microscopic images of the topotecan MSP (E) . MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Representative digital images of the master mold (A) , PDMS mold (B) , and stereomicroscopic images of the topotecan MSP at different magnifications (C and D) , scanning electron microscopic images of the topotecan MSP (E) . MSP = microneedle scleral patch; PDMS = polydimethylsiloxane.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques:

    Force-displacement curves obtained after compression test of blank and topotecan MSP (A) , and insertion test of blank and topotecan MSP into the excised goat sclera (B) . MSP = microneedle scleral patch.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Force-displacement curves obtained after compression test of blank and topotecan MSP (A) , and insertion test of blank and topotecan MSP into the excised goat sclera (B) . MSP = microneedle scleral patch.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques:

    Representative Fourier-transform infrared spectra (A) , powder X-ray diffraction peak pattern (B) , differential scanning colorimetry thermograms (C) , and thermogravimetry analysis thermograms (D) of pure topotecan HCl, sodium hyaluronate, physical mixture (topotecan HCl + sodium hyaluronate), and topotecan MSP. The physical mixture was prepared with topotecan HCl: sodium hyaluronate ratio same as that in topotecan MSP. MSP = microneedle scleral patch.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Representative Fourier-transform infrared spectra (A) , powder X-ray diffraction peak pattern (B) , differential scanning colorimetry thermograms (C) , and thermogravimetry analysis thermograms (D) of pure topotecan HCl, sodium hyaluronate, physical mixture (topotecan HCl + sodium hyaluronate), and topotecan MSP. The physical mixture was prepared with topotecan HCl: sodium hyaluronate ratio same as that in topotecan MSP. MSP = microneedle scleral patch.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques: Fourier Transform Infrared Spectroscopy, Colorimetric Assay

    Scanning electron microscopic images of in vitro dissolution of topotecan MSP at different time points of 0 second, 5 seconds, 10 seconds, 15 seconds, 20 seconds, and 25 seconds. MSP = microneedle scleral patch.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Scanning electron microscopic images of in vitro dissolution of topotecan MSP at different time points of 0 second, 5 seconds, 10 seconds, 15 seconds, 20 seconds, and 25 seconds. MSP = microneedle scleral patch.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques: In Vitro, Dissolution

    Cumulative amount of topotecan permeated across the excised goat sclera after administration of the MSP and topotecan solution. Asterisk (∗) represents that the value is significantly different at P < 0.05 compared with topotecan solution. MSP = microneedle scleral patch.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Cumulative amount of topotecan permeated across the excised goat sclera after administration of the MSP and topotecan solution. Asterisk (∗) represents that the value is significantly different at P < 0.05 compared with topotecan solution. MSP = microneedle scleral patch.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques:

    Ex vivo distribution of topotecan in various ocular tissues after application for 1 hour (A) and 4 hours (B) . MSP = microneedle scleral patch.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Ex vivo distribution of topotecan in various ocular tissues after application for 1 hour (A) and 4 hours (B) . MSP = microneedle scleral patch.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques: Ex Vivo

    Topotecan distribution in different ocular tissues in rabbit eyes at different time points, including 1 hour (A) , 2 hours (B) , and 8 hours (C) , after intravitreal injection and MSP application. MSP = microneedle scleral patch.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Topotecan distribution in different ocular tissues in rabbit eyes at different time points, including 1 hour (A) , 2 hours (B) , and 8 hours (C) , after intravitreal injection and MSP application. MSP = microneedle scleral patch.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques: Injection

    Retinal fundus images of rabbit ocular model before and after application of topotecan MSP. MSP = microneedle scleral patch.

    Journal: Ophthalmology Science

    Article Title: Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma

    doi: 10.1016/j.xops.2026.101226

    Figure Lengend Snippet: Retinal fundus images of rabbit ocular model before and after application of topotecan MSP. MSP = microneedle scleral patch.

    Article Snippet: Topotecan hydrochloride was procured from TCI Chemicals Ltd.

    Techniques:

    NUDT1 expression predicts differential therapeutic responses in OS. ( A-L ) Correlation analysis between NUDT1 expression and drug sensitivity (IC 50 ) for chemotherapeutic and targeted agents, including Dihydrorotenone, Foretinib, Gallibiscoquinazole, Irinotecan, Palbociclib, Sabutoclax, Topotecan, Doramapimod, Nelarabine, Ruxolitinib, Selumetinib, and Staurosporine based on the TARGET cohort. ( M-P ) In vitro validation of NUDT1-mediated chemosensitization. Cell viability curves for 143B ( M , O ) and U2OS ( N , P ) cells treated with varying concentrations of Irinotecan ( M , N ) and Topotecan ( O , P ) following NUDT1 overexpress. The IC 50 values (shown in tables) demonstrate that NUDT1 deficiency significantly enhances the sensitivity of OS cells to both chemotherapeutic agents. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Drug sensitivity prediction was conducted using independent biological samples from the TARGET cohort. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001)

    Journal: Cancer Cell International

    Article Title: NUDT1 drives osteosarcoma progression and serves as a robust predictor of clinical outcomes

    doi: 10.1186/s12935-026-04347-7

    Figure Lengend Snippet: NUDT1 expression predicts differential therapeutic responses in OS. ( A-L ) Correlation analysis between NUDT1 expression and drug sensitivity (IC 50 ) for chemotherapeutic and targeted agents, including Dihydrorotenone, Foretinib, Gallibiscoquinazole, Irinotecan, Palbociclib, Sabutoclax, Topotecan, Doramapimod, Nelarabine, Ruxolitinib, Selumetinib, and Staurosporine based on the TARGET cohort. ( M-P ) In vitro validation of NUDT1-mediated chemosensitization. Cell viability curves for 143B ( M , O ) and U2OS ( N , P ) cells treated with varying concentrations of Irinotecan ( M , N ) and Topotecan ( O , P ) following NUDT1 overexpress. The IC 50 values (shown in tables) demonstrate that NUDT1 deficiency significantly enhances the sensitivity of OS cells to both chemotherapeutic agents. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001). Drug sensitivity prediction was conducted using independent biological samples from the TARGET cohort. For quantitative analyses, data are presented as mean ± SD. Statistical significance was determined using Student’s t-test (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001)

    Article Snippet: Topotecan (#HY-13768) and Irinotecan (#HY-16562) were purchased from MedChemExpress.

    Techniques: Expressing, In Vitro, Biomarker Discovery