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telaglenastat  (MedChemExpress)


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    MedChemExpress telaglenastat
    Telaglenastat, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 134 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/telaglenastat/Telaglenastat/pm42442323-132-4-5
    Average 96 stars, based on 134 article reviews
    telaglenastat - by Bioz Stars, 2026-09
    96/100 stars

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    other:

    Article Title: Metabolic reprogramming controlled by NF-YA alternative splicing creates therapeutic opportunities in colorectal cancer
    Article Snippet: When indicated, we concomitantly added Gln pathways inhibitors: 10 μg/ml Glufosinate-ammonium (Sigma-Aldrich, #45520), 1μM V-9302 (MedChemExpress, #HY-112683A) or 25nM Telaglenastat -CB-839-(MedChemExpress, #HY-12248).

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    Article Title: L-glutamine supplementation improves porcine sperm quality and early embryo development during in vitro fertilization.
    Article Snippet: L-glutamine (Gln), as a key additive in porcine sperm capacitation medium and in vitro fertilization (IVF) systems, has been shown to significantly improve sperm motility and survival rates.. However, its precise roles during porcine IVF and subsequent early embryonic development remain elusive.. This study utilized an IVF model in pigs to investigate the effects of glutamine on sperm quality and embryonic development.



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    A. Primary FLT3-ITD AML cells cultured in hypoxia with and without glutamine (2 mM), with <t>telaglenastat</t> (100 nM) and with glutamine and telaglenastat and harvested at 0, 48 and 96 hours were immunoblotted for c-CBL, FLT3, p-STAT5, STAT5 and vinculin expression, and bands were quantified by densitometry. Immunoblots and densitometric analysis are shown. B. MOLM-14 cells and primary FLT3-ITD AML cells from two patients were cultured in hypoxia in the presence of glutamine with telaglenastat and the FLT3 inhibitors gilteritinib or quizartinib at diverse concentrations. Drug combination effects were analyzed using the Chou-Talalay method. Combination index <1, =1 or >1 indicated synergy, additivity and antagonism, respectively. Synergistic effects were seen.
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    A. Primary FLT3-ITD AML cells cultured in hypoxia with and without glutamine (2 mM), with telaglenastat (100 nM) and with glutamine and telaglenastat and harvested at 0, 48 and 96 hours were immunoblotted for c-CBL, FLT3, p-STAT5, STAT5 and vinculin expression, and bands were quantified by densitometry. Immunoblots and densitometric analysis are shown. B. MOLM-14 cells and primary FLT3-ITD AML cells from two patients were cultured in hypoxia in the presence of glutamine with telaglenastat and the FLT3 inhibitors gilteritinib or quizartinib at diverse concentrations. Drug combination effects were analyzed using the Chou-Talalay method. Combination index <1, =1 or >1 indicated synergy, additivity and antagonism, respectively. Synergistic effects were seen.

    Journal: bioRxiv

    Article Title: Glutamine-Dependent Downregulation of FLT3-ITD is a Mechanism of FLT3 Inhibitor Resistance in FLT3-ITD AML in Hypoxia

    doi: 10.64898/2026.05.02.722336

    Figure Lengend Snippet: A. Primary FLT3-ITD AML cells cultured in hypoxia with and without glutamine (2 mM), with telaglenastat (100 nM) and with glutamine and telaglenastat and harvested at 0, 48 and 96 hours were immunoblotted for c-CBL, FLT3, p-STAT5, STAT5 and vinculin expression, and bands were quantified by densitometry. Immunoblots and densitometric analysis are shown. B. MOLM-14 cells and primary FLT3-ITD AML cells from two patients were cultured in hypoxia in the presence of glutamine with telaglenastat and the FLT3 inhibitors gilteritinib or quizartinib at diverse concentrations. Drug combination effects were analyzed using the Chou-Talalay method. Combination index <1, =1 or >1 indicated synergy, additivity and antagonism, respectively. Synergistic effects were seen.

    Article Snippet: The FLT3 inhibitors gilteritinib (ASP 2215; S7754) (Type I) and quizartinib (AC220, S1526) (Type II) were from Selleck Chemicals, Houston, TX, USA, and the glutaminase inhibitor telaglenastat (CB-839; MedChemExpress, Monmouth Junction, NJ, USA, HY-12248).

    Techniques: Cell Culture, Expressing, Western Blot