tak 243 mln7243 (MedChemExpress)
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tak 243 mln7243
Tak 243 Mln7243, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 146 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tak/TAK-243/pm42863465-261-164-165
Average 97 stars, based on 146 article reviews
Tak 243 Mln7243, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 97/100, based on 146 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tak/TAK-243/pm42863465-261-164-165
Average 97 stars, based on 146 article reviews
tak 243 mln7243 - by Bioz Stars,
2026-11
97/100 stars
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Infection:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Cell Culture:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Quantitative RT-PCR:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Control:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Virus:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Incubation:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Labeling:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Immunofluorescence:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Staining:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Derivative Assay:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Molecular Weight:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Injection:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). MTT Assay:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). CCK-8 Assay:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). SYBR Green Assay:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Enzyme-linked Immunosorbent Assay:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Bioprocessing:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Inhibition:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Migration:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Flow Cytometry:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). Two Tailed Test:Article Title: CDC7 is a targetable regulator of advanced prostate cancer. Article Snippet: Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. Article Snippet: Secondary horseradish peroxidase (HRP)-conjugated anti-mouse and anti-rabbit antibodies were from GE Healthcare, and the HRP-conjugated anti-goat antibody was purchased from Santa Cruz Biotechnology. Article Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion Article Snippet: Article Title: Two pectic polysaccharides from Stemona tuberosa Lour. roots with detailed structural features display potent immunoenhancing activity via TLR signaling pathway. Article Snippet: Stemona tuberosa Lour., a noted traditional Chinese medicine, exerts potent pharmacological effects, yet its key pectic polysaccharides, especially their chemical structures, remain poorly understood, impeding further investigation and development.. In this study, two pectin polysaccharides (STP-3-1 and STP-3-2) were isolated from the roots for the first time.. Using HPLC, methylation-GC–MS, and 1D/2D NMR, their structures were elucidated. Article Title: Activation of macrophages by the pectin polysaccharide from the immature fruit of Citrus aurantium 'Changshan-huyou' and its molecular mechanisms based on transcriptomics. Article Snippet: In this study, the pectin polysaccharide from the immature fruit of Citrus aurantium ‘Changshan-huyou’ (CSHYP) was investigated for the immunoregulatory potentials on cyclophosphamide (CTX)-induced immunosuppressive mice and RAW264.7 cells as well as its molecular mechanisms based on RNA-seq analysis.. CSHYP restored the immunologic function in immunosuppressive mice induced by CTX.. Meanwhile, CSHYP significantly activated RAW264.7 macrophages, enhancing their phagocytosis, promoting the production of NO, ROS, and multiple cytokines, as well as upregulating the expression of costimulatory molecules (CD80, CD86, and CD206). |