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h 151 t5674  (TargetMol)


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    TargetMol h 151 t5674
    H 151 T5674, supplied by TargetMol, used in various techniques. Bioz Stars score: 99/100, based on 25 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/h 151 t5674/product/TargetMol
    Average 99 stars, based on 25 article reviews
    h 151 t5674 - by Bioz Stars, 2026-03
    99/100 stars

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    Cells were treated with the STING inhibitor H151 (10 μM), the TBK1/IKKε inhibitor amlexanox (20 μM) or the NF-κB inhibitor BI605906 (10 μM) alone or in combination with A 3×8 Gy X-rays in MDA-MB-468, B 8 Gy C-ions and 3 μM SAR405 in MDA-MB-436 and C 3 μM SAR405 in MDA-MB-231. H151, amlexanox and BI605906 were applied directly after the last irradiation/SAR405 treatment and kept for 72 hours. All cells were harvested after 72 hours of treatment. RT-qPCR analysis of IFNB1 , CXCL10 , PD-L1 and IL-6 mRNA levels is shown. TBP served as a housekeeping gene. The bars and error bars represent mean values ± standard deviation. Three biologically independent experiments were performed. P-values were calculated with a one-way ANOVA (* ≤ 0.05; **≤ 0.01; ***≤ 0.005, ****≤0.0001).

    Journal: Cell Death & Disease

    Article Title: Molecular features of TNBC govern heterogeneity in the response to radiation and autophagy inhibition

    doi: 10.1038/s41419-025-07873-w

    Figure Lengend Snippet: Cells were treated with the STING inhibitor H151 (10 μM), the TBK1/IKKε inhibitor amlexanox (20 μM) or the NF-κB inhibitor BI605906 (10 μM) alone or in combination with A 3×8 Gy X-rays in MDA-MB-468, B 8 Gy C-ions and 3 μM SAR405 in MDA-MB-436 and C 3 μM SAR405 in MDA-MB-231. H151, amlexanox and BI605906 were applied directly after the last irradiation/SAR405 treatment and kept for 72 hours. All cells were harvested after 72 hours of treatment. RT-qPCR analysis of IFNB1 , CXCL10 , PD-L1 and IL-6 mRNA levels is shown. TBP served as a housekeeping gene. The bars and error bars represent mean values ± standard deviation. Three biologically independent experiments were performed. P-values were calculated with a one-way ANOVA (* ≤ 0.05; **≤ 0.01; ***≤ 0.005, ****≤0.0001).

    Article Snippet: The STING inhibitor H151 (TargetMol, T5674) and the NF-κB inhibitor BI-605906 (THP Medical Products, HY-13019) were used at 10 μM.

    Techniques: Irradiation, Quantitative RT-PCR, Standard Deviation