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stf-62247  (Millipore)


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    Structured Review

    Millipore stf-62247
    Stf 62247, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/stf-62247/stf+62247/pm35792180-177-31-34
    Average 90 stars, based on 1 article reviews
    stf-62247 - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Incubation:

    Article Title: Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity through CBR1 inhibition mechanism.
    Article Snippet: Doxorubicin (DOX) is classified by World Health Organization (WHO) as an essential medicine for cancer.. However, its clinical application is limited due to resistance development and cardiotoxicity.. Many attempts have been made to address these issues with some focused on finding a potential adjuvant therapy.

    Article Title: Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines
    Article Snippet: STF-62247, an autophagy inducer, was purchased from Calbiochem (Darmstadt, Germany).

    Positive Control:

    Article Title: Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity through CBR1 inhibition mechanism.
    Article Snippet: Doxorubicin (DOX) is classified by World Health Organization (WHO) as an essential medicine for cancer.. However, its clinical application is limited due to resistance development and cardiotoxicity.. Many attempts have been made to address these issues with some focused on finding a potential adjuvant therapy.

    Article Title: Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines
    Article Snippet: STF-62247, an autophagy inducer, was purchased from Calbiochem (Darmstadt, Germany).

    Concentration Assay:

    Article Title: Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity through CBR1 inhibition mechanism.
    Article Snippet: Doxorubicin (DOX) is classified by World Health Organization (WHO) as an essential medicine for cancer.. However, its clinical application is limited due to resistance development and cardiotoxicity.. Many attempts have been made to address these issues with some focused on finding a potential adjuvant therapy.

    Article Title: Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines
    Article Snippet: STF-62247, an autophagy inducer, was purchased from Calbiochem (Darmstadt, Germany).



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    Stf 62247, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Fig. 2 Preparation and Characterization of STF-BMS@ZIF-8/PEG-FA. A, B TEM images of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. Scale: 20 nm. C, D TEM test the particle size distribution of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. E Ultraviolet–visible spectroscopy of ZIF-8, STF, STF-BMS@ZIF-8, STF-BMS@ ZIF-8/PEG-FA. F Zeta potentials of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA (n = 3). G, H pH-responsive release percentage of STF and BMS from STF-BMS@ZIF8/PEG-FA in different buffers at pH 5.5 and 7.4. I XRD of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. J FITR of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. K Thermogravimetric analysis of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. L XPS spectra of ZIF-8, STF-BMS@ ZIF-8, and STF-BMS@ZIF-8/PEG-FA (C1s, N1s, O1s, S2p). ZIF-8, zeolitic imidazolate framework-8; STF, <t>STF62247;</t> BMS202, BMS; SBZ, STF- BMS@ZIF-8; SBZP, STF- BMS @ZIF-8@PEG-FA; TEM, Transmission emission micrography; FTIR, Fourier transform IR; XRD, X-ray diffraction; XPS, X-ray photoelectron spectroscopy; FITC, Fluorescein Isothiocyanate
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    Fig. 2 Preparation and Characterization of STF-BMS@ZIF-8/PEG-FA. A, B TEM images of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. Scale: 20 nm. C, D TEM test the particle size distribution of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. E Ultraviolet–visible spectroscopy of ZIF-8, STF, STF-BMS@ZIF-8, STF-BMS@ ZIF-8/PEG-FA. F Zeta potentials of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA (n = 3). G, H pH-responsive release percentage of STF and BMS from STF-BMS@ZIF8/PEG-FA in different buffers at pH 5.5 and 7.4. I XRD of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. J FITR of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. K Thermogravimetric analysis of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. L XPS spectra of ZIF-8, STF-BMS@ ZIF-8, and STF-BMS@ZIF-8/PEG-FA (C1s, N1s, O1s, S2p). ZIF-8, zeolitic imidazolate framework-8; STF, <t>STF62247;</t> BMS202, BMS; SBZ, STF- BMS@ZIF-8; SBZP, STF- BMS @ZIF-8@PEG-FA; TEM, Transmission emission micrography; FTIR, Fourier transform IR; XRD, X-ray diffraction; XPS, X-ray photoelectron spectroscopy; FITC, Fluorescein Isothiocyanate
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    Fig. 2 Preparation and Characterization of STF-BMS@ZIF-8/PEG-FA. A, B TEM images of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. Scale: 20 nm. C, D TEM test the particle size distribution of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. E Ultraviolet–visible spectroscopy of ZIF-8, STF, STF-BMS@ZIF-8, STF-BMS@ ZIF-8/PEG-FA. F Zeta potentials of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA (n = 3). G, H pH-responsive release percentage of STF and BMS from STF-BMS@ZIF8/PEG-FA in different buffers at pH 5.5 and 7.4. I XRD of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. J FITR of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. K Thermogravimetric analysis of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. L XPS spectra of ZIF-8, STF-BMS@ ZIF-8, and STF-BMS@ZIF-8/PEG-FA (C1s, N1s, O1s, S2p). ZIF-8, zeolitic imidazolate framework-8; STF, <t>STF62247;</t> BMS202, BMS; SBZ, STF- BMS@ZIF-8; SBZP, STF- BMS @ZIF-8@PEG-FA; TEM, Transmission emission micrography; FTIR, Fourier transform IR; XRD, X-ray diffraction; XPS, X-ray photoelectron spectroscopy; FITC, Fluorescein Isothiocyanate
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    stf-62247 (ref# 189497)  (Merck KGaA)
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    Fig. 2 Preparation and Characterization of STF-BMS@ZIF-8/PEG-FA. A, B TEM images of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. Scale: 20 nm. C, D TEM test the particle size distribution of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. E Ultraviolet–visible spectroscopy of ZIF-8, STF, STF-BMS@ZIF-8, STF-BMS@ ZIF-8/PEG-FA. F Zeta potentials of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA (n = 3). G, H pH-responsive release percentage of STF and BMS from STF-BMS@ZIF8/PEG-FA in different buffers at pH 5.5 and 7.4. I XRD of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. J FITR of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. K Thermogravimetric analysis of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. L XPS spectra of ZIF-8, STF-BMS@ ZIF-8, and STF-BMS@ZIF-8/PEG-FA (C1s, N1s, O1s, S2p). ZIF-8, zeolitic imidazolate framework-8; STF, <t>STF62247;</t> BMS202, BMS; SBZ, STF- BMS@ZIF-8; SBZP, STF- BMS @ZIF-8@PEG-FA; TEM, Transmission emission micrography; FTIR, Fourier transform IR; XRD, X-ray diffraction; XPS, X-ray photoelectron spectroscopy; FITC, Fluorescein Isothiocyanate
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    stf-62247  (Millipore)
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    Fig. 2 Preparation and Characterization of STF-BMS@ZIF-8/PEG-FA. A, B TEM images of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. Scale: 20 nm. C, D TEM test the particle size distribution of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. E Ultraviolet–visible spectroscopy of ZIF-8, STF, STF-BMS@ZIF-8, STF-BMS@ ZIF-8/PEG-FA. F Zeta potentials of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA (n = 3). G, H pH-responsive release percentage of STF and BMS from STF-BMS@ZIF8/PEG-FA in different buffers at pH 5.5 and 7.4. I XRD of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. J FITR of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. K Thermogravimetric analysis of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. L XPS spectra of ZIF-8, STF-BMS@ ZIF-8, and STF-BMS@ZIF-8/PEG-FA (C1s, N1s, O1s, S2p). ZIF-8, zeolitic imidazolate framework-8; STF, <t>STF62247;</t> BMS202, BMS; SBZ, STF- BMS@ZIF-8; SBZP, STF- BMS @ZIF-8@PEG-FA; TEM, Transmission emission micrography; FTIR, Fourier transform IR; XRD, X-ray diffraction; XPS, X-ray photoelectron spectroscopy; FITC, Fluorescein Isothiocyanate
    Stf 62247, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/stf-62247/stf+62247/pm35792180-177-31-34
    Average 90 stars, based on 1 article reviews
    stf-62247 - by Bioz Stars, 2026-09
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Fig. 2 Preparation and Characterization of STF-BMS@ZIF-8/PEG-FA. A, B TEM images of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. Scale: 20 nm. C, D TEM test the particle size distribution of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. E Ultraviolet–visible spectroscopy of ZIF-8, STF, STF-BMS@ZIF-8, STF-BMS@ ZIF-8/PEG-FA. F Zeta potentials of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA (n = 3). G, H pH-responsive release percentage of STF and BMS from STF-BMS@ZIF8/PEG-FA in different buffers at pH 5.5 and 7.4. I XRD of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. J FITR of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. K Thermogravimetric analysis of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. L XPS spectra of ZIF-8, STF-BMS@ ZIF-8, and STF-BMS@ZIF-8/PEG-FA (C1s, N1s, O1s, S2p). ZIF-8, zeolitic imidazolate framework-8; STF, STF62247; BMS202, BMS; SBZ, STF- BMS@ZIF-8; SBZP, STF- BMS @ZIF-8@PEG-FA; TEM, Transmission emission micrography; FTIR, Fourier transform IR; XRD, X-ray diffraction; XPS, X-ray photoelectron spectroscopy; FITC, Fluorescein Isothiocyanate

    Journal: Journal of nanobiotechnology

    Article Title: Autophagy-amplifying nanoparticles evoke immunogenic cell death combined with anti-PD-1/PD-L1 for residual tumors immunotherapy after RFA.

    doi: 10.1186/s12951-023-02067-y

    Figure Lengend Snippet: Fig. 2 Preparation and Characterization of STF-BMS@ZIF-8/PEG-FA. A, B TEM images of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. Scale: 20 nm. C, D TEM test the particle size distribution of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. E Ultraviolet–visible spectroscopy of ZIF-8, STF, STF-BMS@ZIF-8, STF-BMS@ ZIF-8/PEG-FA. F Zeta potentials of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA (n = 3). G, H pH-responsive release percentage of STF and BMS from STF-BMS@ZIF8/PEG-FA in different buffers at pH 5.5 and 7.4. I XRD of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. J FITR of ZIF-8, STF-BMS@ZIF-8, and STF-BMS@ZIF-8/PEG-FA. K Thermogravimetric analysis of ZIF-8 and STF-BMS@ZIF-8/PEG-FA. L XPS spectra of ZIF-8, STF-BMS@ ZIF-8, and STF-BMS@ZIF-8/PEG-FA (C1s, N1s, O1s, S2p). ZIF-8, zeolitic imidazolate framework-8; STF, STF62247; BMS202, BMS; SBZ, STF- BMS@ZIF-8; SBZP, STF- BMS @ZIF-8@PEG-FA; TEM, Transmission emission micrography; FTIR, Fourier transform IR; XRD, X-ray diffraction; XPS, X-ray photoelectron spectroscopy; FITC, Fluorescein Isothiocyanate

    Article Snippet: Zn (NO3)2•6H2O and 2-MeIM were purchased from Aladdin Holdings Group Co., Ltd (Shanghai); PEGFA 2000, ICG, and FITC from Rixi Biotechnology Co., Ltd. (Xi’an); BMS202 (HY-19745), STF62247 (HY100746), 3-MA (HY-19312), and Chloroquine (HY17589A) from MedChemExpress (Shanghai); ethanol from Guangzhou Chemical Reagent Factory.

    Techniques: Spectroscopy, Transmission Assay

    Fig. 4 SZP enhances autophagy in sublethally heated HCC cells. A Diagram illustrating how autophagy was induced by SZP. B The ultrastructure of tumor cells after SZP NPs treatment observed via TEM, with autophagosomes and autolysosomes pointed out by arrows. Scale: 1 µm. C Immunoblotting of LC3B in SMMC7721 and Huh7 cells pre-treated with 3MA under sublethal heat stress caused by SZP. D Immunoblotting of LC3B and P62 in SMMC7721 and Huh7 cells pre-treated with CQ under sublethal heat stress induced by SZP. E–G Representative CLSM images and quantitative analysis of HCC cells transfected with mRFP-eGFP-LC3 plasmid under the influence of different groups (arrow pointing towards green spots, red spots, and yellow spots). Scale: 20 µm. Results were expressed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. SZP, STF62247@ZIF-8/PEG-FA; TEM, Transmission Electron Microscope; 3MA, 3-Methyladenine; CQ, Chloroquine

    Journal: Journal of nanobiotechnology

    Article Title: Autophagy-amplifying nanoparticles evoke immunogenic cell death combined with anti-PD-1/PD-L1 for residual tumors immunotherapy after RFA.

    doi: 10.1186/s12951-023-02067-y

    Figure Lengend Snippet: Fig. 4 SZP enhances autophagy in sublethally heated HCC cells. A Diagram illustrating how autophagy was induced by SZP. B The ultrastructure of tumor cells after SZP NPs treatment observed via TEM, with autophagosomes and autolysosomes pointed out by arrows. Scale: 1 µm. C Immunoblotting of LC3B in SMMC7721 and Huh7 cells pre-treated with 3MA under sublethal heat stress caused by SZP. D Immunoblotting of LC3B and P62 in SMMC7721 and Huh7 cells pre-treated with CQ under sublethal heat stress induced by SZP. E–G Representative CLSM images and quantitative analysis of HCC cells transfected with mRFP-eGFP-LC3 plasmid under the influence of different groups (arrow pointing towards green spots, red spots, and yellow spots). Scale: 20 µm. Results were expressed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. SZP, STF62247@ZIF-8/PEG-FA; TEM, Transmission Electron Microscope; 3MA, 3-Methyladenine; CQ, Chloroquine

    Article Snippet: Zn (NO3)2•6H2O and 2-MeIM were purchased from Aladdin Holdings Group Co., Ltd (Shanghai); PEGFA 2000, ICG, and FITC from Rixi Biotechnology Co., Ltd. (Xi’an); BMS202 (HY-19745), STF62247 (HY100746), 3-MA (HY-19312), and Chloroquine (HY17589A) from MedChemExpress (Shanghai); ethanol from Guangzhou Chemical Reagent Factory.

    Techniques: Western Blot, Transfection, Plasmid Preparation, Transmission Assay, Microscopy

    Fig. 5 SZP mediates ACD. A The dose–response curve for CCK8 assay of IC50 of STF62247 in different concentrations treating cells at 37 °C and 47 °C for 24 h (n = 3). B The dose–response curve for CCK8 assay of IC50 of STF62247 and SZP NPs in different concentrations treating HCC cells at 47 °C for 24 h (n = 3). C, F Live/dead cells double staining and quantitative analysis of sublethally heated SMMC7721 and Huh7 cells exposed to different groups (n = 4). Scale: 1000 µm. D Analysis of the proliferation of sublethally heated SMMC7721 and Huh7 cells under influence of different groups by CCK8 (n = 3). E, G Representative flow cytometry plots and quantitative analysis of apoptosis in sublethally heated SMMC7721 and Huh7 cells under influence of different conditions (n = 3). H Immunoblotting of p-mTOR, t-mTOR, P62, and LC3B in sublethally heated SMMC7721 and Huh7 cells under influence of different groups. The results were expressed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. ACD, Autophagy-dependent cell death; IC50, Half maximal inhibitory concentration

    Journal: Journal of nanobiotechnology

    Article Title: Autophagy-amplifying nanoparticles evoke immunogenic cell death combined with anti-PD-1/PD-L1 for residual tumors immunotherapy after RFA.

    doi: 10.1186/s12951-023-02067-y

    Figure Lengend Snippet: Fig. 5 SZP mediates ACD. A The dose–response curve for CCK8 assay of IC50 of STF62247 in different concentrations treating cells at 37 °C and 47 °C for 24 h (n = 3). B The dose–response curve for CCK8 assay of IC50 of STF62247 and SZP NPs in different concentrations treating HCC cells at 47 °C for 24 h (n = 3). C, F Live/dead cells double staining and quantitative analysis of sublethally heated SMMC7721 and Huh7 cells exposed to different groups (n = 4). Scale: 1000 µm. D Analysis of the proliferation of sublethally heated SMMC7721 and Huh7 cells under influence of different groups by CCK8 (n = 3). E, G Representative flow cytometry plots and quantitative analysis of apoptosis in sublethally heated SMMC7721 and Huh7 cells under influence of different conditions (n = 3). H Immunoblotting of p-mTOR, t-mTOR, P62, and LC3B in sublethally heated SMMC7721 and Huh7 cells under influence of different groups. The results were expressed as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. ACD, Autophagy-dependent cell death; IC50, Half maximal inhibitory concentration

    Article Snippet: Zn (NO3)2•6H2O and 2-MeIM were purchased from Aladdin Holdings Group Co., Ltd (Shanghai); PEGFA 2000, ICG, and FITC from Rixi Biotechnology Co., Ltd. (Xi’an); BMS202 (HY-19745), STF62247 (HY100746), 3-MA (HY-19312), and Chloroquine (HY17589A) from MedChemExpress (Shanghai); ethanol from Guangzhou Chemical Reagent Factory.

    Techniques: CCK-8 Assay, Double Staining, Flow Cytometry, Western Blot, Concentration Assay