Review



stat6 pathway  (MedChemExpress)


Bioz Verified Symbol MedChemExpress is a verified supplier
Bioz Manufacturer Symbol MedChemExpress manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 95
      Buy from Supplier

    Structured Review

    MedChemExpress stat6 pathway
    Stat6 Pathway, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 62 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/stat6 pathway/product/MedChemExpress
    Average 95 stars, based on 62 article reviews
    stat6 pathway - by Bioz Stars, 2026-03
    95/100 stars

    Images



    Similar Products

    stat6 pathway  (MedChemExpress)
    95
    MedChemExpress stat6 pathway
    Stat6 Pathway, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/stat6 pathway/product/MedChemExpress
    Average 95 stars, based on 1 article reviews
    stat6 pathway - by Bioz Stars, 2026-03
    95/100 stars
    		  Buy from Supplier
    anti b220 350 beads  (Miltenyi Biotec)
    94
    Miltenyi Biotec anti b220 350 beads
    Anti B220 350 Beads, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti b220 350 beads/product/Miltenyi Biotec
    Average 94 stars, based on 1 article reviews
    anti b220 350 beads - by Bioz Stars, 2026-03
    94/100 stars
    		  Buy from Supplier
    stat6 phosphorylation inhibitor as1517499  (MedChemExpress)
    95
    MedChemExpress stat6 phosphorylation inhibitor as1517499
    (A, B) RAW264.7 cells were infected with ME49 wt or ME49Δ gra3 for 24 h. Cell lysates were analyzed by Western blot for total <t>STAT6</t> and phospho‑STAT6 (p‑STAT6). (C, D) Cells were pretreated with the STING inhibitor H‑151 (1 μM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (E, F) Cells were pretreated with the <t>AS1517499</t> (100 nM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (G) Following the same pretreatment and infection protocol, intracellular parasite replication was assessed by examining at least 200 vacuoles and categorizing them based on the number of parasites per vacuole (2, 4, 8, or >8). Data were presented as the mean ± SD from three independent experiments. Statistical significance is indicated by * p < 0.05, ** p < 0.01 and *** p < 0.001. Data were compared using one-way analysis of variance.
    Stat6 Phosphorylation Inhibitor As1517499, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/stat6 phosphorylation inhibitor as1517499/product/MedChemExpress
    Average 95 stars, based on 1 article reviews
    stat6 phosphorylation inhibitor as1517499 - by Bioz Stars, 2026-03
    95/100 stars
    		  Buy from Supplier
    stat6  (MedChemExpress)
    94
    MedChemExpress stat6
    (A, B) RAW264.7 cells were infected with ME49 wt or ME49Δ gra3 for 24 h. Cell lysates were analyzed by Western blot for total <t>STAT6</t> and phospho‑STAT6 (p‑STAT6). (C, D) Cells were pretreated with the STING inhibitor H‑151 (1 μM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (E, F) Cells were pretreated with the <t>AS1517499</t> (100 nM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (G) Following the same pretreatment and infection protocol, intracellular parasite replication was assessed by examining at least 200 vacuoles and categorizing them based on the number of parasites per vacuole (2, 4, 8, or >8). Data were presented as the mean ± SD from three independent experiments. Statistical significance is indicated by * p < 0.05, ** p < 0.01 and *** p < 0.001. Data were compared using one-way analysis of variance.
    Stat6, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/stat6/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    stat6 - by Bioz Stars, 2026-03
    94/100 stars
    		  Buy from Supplier
    stat6 in 1  (MedChemExpress)
    94
    MedChemExpress stat6 in 1
    (A, B) RAW264.7 cells were infected with ME49 wt or ME49Δ gra3 for 24 h. Cell lysates were analyzed by Western blot for total <t>STAT6</t> and phospho‑STAT6 (p‑STAT6). (C, D) Cells were pretreated with the STING inhibitor H‑151 (1 μM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (E, F) Cells were pretreated with the <t>AS1517499</t> (100 nM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (G) Following the same pretreatment and infection protocol, intracellular parasite replication was assessed by examining at least 200 vacuoles and categorizing them based on the number of parasites per vacuole (2, 4, 8, or >8). Data were presented as the mean ± SD from three independent experiments. Statistical significance is indicated by * p < 0.05, ** p < 0.01 and *** p < 0.001. Data were compared using one-way analysis of variance.
    Stat6 In 1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/stat6 in 1/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    stat6 in 1 - by Bioz Stars, 2026-03
    94/100 stars
    		  Buy from Supplier
    stat6 in 3  (MedChemExpress)
    94
    MedChemExpress stat6 in 3
    (A, B) RAW264.7 cells were infected with ME49 wt or ME49Δ gra3 for 24 h. Cell lysates were analyzed by Western blot for total <t>STAT6</t> and phospho‑STAT6 (p‑STAT6). (C, D) Cells were pretreated with the STING inhibitor H‑151 (1 μM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (E, F) Cells were pretreated with the <t>AS1517499</t> (100 nM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (G) Following the same pretreatment and infection protocol, intracellular parasite replication was assessed by examining at least 200 vacuoles and categorizing them based on the number of parasites per vacuole (2, 4, 8, or >8). Data were presented as the mean ± SD from three independent experiments. Statistical significance is indicated by * p < 0.05, ** p < 0.01 and *** p < 0.001. Data were compared using one-way analysis of variance.
    Stat6 In 3, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/stat6 in 3/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    stat6 in 3 - by Bioz Stars, 2026-03
    94/100 stars
    		  Buy from Supplier
    stat6in 3  (MedChemExpress)
    94
    MedChemExpress stat6in 3
    (A, B) RAW264.7 cells were infected with ME49 wt or ME49Δ gra3 for 24 h. Cell lysates were analyzed by Western blot for total <t>STAT6</t> and phospho‑STAT6 (p‑STAT6). (C, D) Cells were pretreated with the STING inhibitor H‑151 (1 μM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (E, F) Cells were pretreated with the <t>AS1517499</t> (100 nM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (G) Following the same pretreatment and infection protocol, intracellular parasite replication was assessed by examining at least 200 vacuoles and categorizing them based on the number of parasites per vacuole (2, 4, 8, or >8). Data were presented as the mean ± SD from three independent experiments. Statistical significance is indicated by * p < 0.05, ** p < 0.01 and *** p < 0.001. Data were compared using one-way analysis of variance.
    Stat6in 3, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/stat6in 3/product/MedChemExpress
    Average 94 stars, based on 1 article reviews
    stat6in 3 - by Bioz Stars, 2026-03
    94/100 stars
    		  Buy from Supplier
    anti stat6  (Proteintech)
    95
    Proteintech anti stat6
    (A, B) RAW264.7 cells were infected with ME49 wt or ME49Δ gra3 for 24 h. Cell lysates were analyzed by Western blot for total <t>STAT6</t> and phospho‑STAT6 (p‑STAT6). (C, D) Cells were pretreated with the STING inhibitor H‑151 (1 μM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (E, F) Cells were pretreated with the <t>AS1517499</t> (100 nM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (G) Following the same pretreatment and infection protocol, intracellular parasite replication was assessed by examining at least 200 vacuoles and categorizing them based on the number of parasites per vacuole (2, 4, 8, or >8). Data were presented as the mean ± SD from three independent experiments. Statistical significance is indicated by * p < 0.05, ** p < 0.01 and *** p < 0.001. Data were compared using one-way analysis of variance.
    Anti Stat6, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti stat6/product/Proteintech
    Average 95 stars, based on 1 article reviews
    anti stat6 - by Bioz Stars, 2026-03
    95/100 stars
    		  Buy from Supplier

    Image Search Results


    (A, B) RAW264.7 cells were infected with ME49 wt or ME49Δ gra3 for 24 h. Cell lysates were analyzed by Western blot for total STAT6 and phospho‑STAT6 (p‑STAT6). (C, D) Cells were pretreated with the STING inhibitor H‑151 (1 μM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (E, F) Cells were pretreated with the AS1517499 (100 nM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (G) Following the same pretreatment and infection protocol, intracellular parasite replication was assessed by examining at least 200 vacuoles and categorizing them based on the number of parasites per vacuole (2, 4, 8, or >8). Data were presented as the mean ± SD from three independent experiments. Statistical significance is indicated by * p < 0.05, ** p < 0.01 and *** p < 0.001. Data were compared using one-way analysis of variance.

    Journal: PLOS Neglected Tropical Diseases

    Article Title: Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation

    doi: 10.1371/journal.pntd.0014035

    Figure Lengend Snippet: (A, B) RAW264.7 cells were infected with ME49 wt or ME49Δ gra3 for 24 h. Cell lysates were analyzed by Western blot for total STAT6 and phospho‑STAT6 (p‑STAT6). (C, D) Cells were pretreated with the STING inhibitor H‑151 (1 μM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (E, F) Cells were pretreated with the AS1517499 (100 nM, MCE) for 1 h before infection with the indicated strains for 24 h, followed by Western blot analysis of STAT6, p‑STAT6 and profilin. (G) Following the same pretreatment and infection protocol, intracellular parasite replication was assessed by examining at least 200 vacuoles and categorizing them based on the number of parasites per vacuole (2, 4, 8, or >8). Data were presented as the mean ± SD from three independent experiments. Statistical significance is indicated by * p < 0.05, ** p < 0.01 and *** p < 0.001. Data were compared using one-way analysis of variance.

    Article Snippet: Treatment with the STAT6 phosphorylation inhibitor AS1517499 (100 nM, MCE) suppressed GRA3-induced STAT6 activation and T. gondii profilin expression ( and ).

    Techniques: Infection, Western Blot

    By engaging host STING, the Toxoplasma gondii protein GRA3 activates TBK1 and IRF3, thereby inducing STAT6 phosphorylation and IRF3-mediated expression of IFN-β and ISG56. This regulated immune activation prevents excessive parasite proliferation, thus facilitating the establishment of a stable chronic infection within the host.

    Journal: PLOS Neglected Tropical Diseases

    Article Title: Toxoplasma gondii GRA3 activates interferon-stimulated genes and STAT6 by the cGAS-STING pathway to promote parasite proliferation

    doi: 10.1371/journal.pntd.0014035

    Figure Lengend Snippet: By engaging host STING, the Toxoplasma gondii protein GRA3 activates TBK1 and IRF3, thereby inducing STAT6 phosphorylation and IRF3-mediated expression of IFN-β and ISG56. This regulated immune activation prevents excessive parasite proliferation, thus facilitating the establishment of a stable chronic infection within the host.

    Article Snippet: Treatment with the STAT6 phosphorylation inhibitor AS1517499 (100 nM, MCE) suppressed GRA3-induced STAT6 activation and T. gondii profilin expression ( and ).

    Techniques: Phospho-proteomics, Expressing, Activation Assay, Infection