Journal: mAbs
Article Title: Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
doi: 10.1080/19420862.2024.2339337
Figure Lengend Snippet: Quality control of the antibody constructs. A. Representative Biacore sensograms displaying monovalent TfR interaction of Bapi-Fab8D3 constructs. B. Representative Biacore sensograms displaying bivalent TfR interaction of 8D3 IgG. C. TfR ELISA analysis of bispecific antibody constructs D. Aβ ELISA analysis of bispecific antibody contructs E. Aβ ELISA analysis of monospecific antibody contructs F. Representative chromatogram of FcRn-column analysis of Bapi FcRn- (purple), Bapi (blue) and positive control Omalizumab (orange).
Article Snippet: Representative Biacore sensograms displaying monovalent TfR interaction of Bapi-Fab8D3 constructs.
Techniques: Control, Construct, Enzyme-linked Immunosorbent Assay, Positive Control