Journal: International Journal of General Medicine
Article Title: Plasma Semaphorin 3A as a Potential Biomarker for Cognitive Impairment in Cerebral Small Vessel Disease
doi: 10.2147/IJGM.S554075
Figure Lengend Snippet: Mediation analysis of plasma Sema3A, CSVD total burden score, and cognitive function. ( A ) Conceptual diagram of mediation analysis with single mediator (M). Total effect of X on Y (c) = indirect effect through M (a × b) + direct effect (c’). ( B ) Sema3A (X), total burden score (M), MoCA (Y). ( C ) Sema3A (X), LI (M), MoCA (Y). ( D ) Sema3A (X), CMBs (M), MoCA (Y). ( E ) Sema3A (X), EPVs (Potter score) (M), MoCA (Y). ( F ) Sema3A (X), WMH (Fazekas score) (M), MoCA (Y). Covariates: age, sex, education.***P < 0.001.
Article Snippet: Plasma Sema3A concentrations were measured using a double antibody sandwich enzyme-linked immunosorbent assay (ELISA, Human SEMA3A ELISA Kit, Elabscience, Wuhan, China).
Techniques: Clinical Proteomics