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c3a receptor antagonist  (MedChemExpress)


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    MedChemExpress c3a receptor antagonist
    C3a Receptor Antagonist, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 46 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sb290157/SB290157/pm42385800-47-13-22
    Average 95 stars, based on 46 article reviews
    c3a receptor antagonist - by Bioz Stars, 2026-09
    95/100 stars

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    Related Articles

    Saline:

    Article Title: Immune Predictors of Radiotherapy Outcomes in Cervical Cancer.
    Article Snippet: .. Starting on day 7 postinoculation, mice in the C3aRA and C3aRA + RT groups received intraperitoneal (i.p.) injections of SB290157 (30 mg/kg in saline; MedChemExpress, HY-101502A) every other day, while control groups received equivalent volumes of saline. ..

    Article Title: Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
    Article Snippet: .. Starting on day 7 post‐inoculation, mice in the C3aRA and C3aRA + RT groups received intraperitoneal (i.p.) injections of SB290157 (30 mg/kg in saline; MedChemExpress, HY‐101502A) every other day, while control groups received equivalent volumes of saline. ..

    Article Title: C3a/C3aR axis is involved in diabetic kidney injury by regulating podocyte mitophagy in diabetic nephropathy.
    Article Snippet: .. Diabetic db/db mice were randomly allocated into two experimental groups (n=6/group): i) A C3aR antagonist (C3aRA)‐treated group, which received intraperitoneal injections of SB290157 (10 mg/kg; cat. no. HY‐101502A/CS‐6852; MedChemExpress) every 48 h (17); and ii) a vehicle group, which received equiva‐ lent volumes of 5% DMSO in sterile saline. ..

    Article Title: C3a/C3aR axis is involved in diabetic kidney injury by regulating podocyte mitophagy in diabetic nephropathy
    Article Snippet: .. Diabetic db/db mice were randomly allocated into two experimental groups (n=6/group): i) A C3aR antagonist (C3aRA)-treated group, which received intraperitoneal injections of SB290157 (10 mg/kg; cat. no. HY-101502A/CS-6852; MedChemExpress) every 48 h ( ); and ii) a vehicle group, which received equivalent volumes of 5% DMSO in sterile saline. ..

    Control:

    Article Title: Immune Predictors of Radiotherapy Outcomes in Cervical Cancer.
    Article Snippet: .. Starting on day 7 postinoculation, mice in the C3aRA and C3aRA + RT groups received intraperitoneal (i.p.) injections of SB290157 (30 mg/kg in saline; MedChemExpress, HY-101502A) every other day, while control groups received equivalent volumes of saline. ..

    Article Title: Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
    Article Snippet: .. Starting on day 7 post‐inoculation, mice in the C3aRA and C3aRA + RT groups received intraperitoneal (i.p.) injections of SB290157 (30 mg/kg in saline; MedChemExpress, HY‐101502A) every other day, while control groups received equivalent volumes of saline. ..

    Sterility:

    Article Title: C3a/C3aR axis is involved in diabetic kidney injury by regulating podocyte mitophagy in diabetic nephropathy.
    Article Snippet: .. Diabetic db/db mice were randomly allocated into two experimental groups (n=6/group): i) A C3aR antagonist (C3aRA)‐treated group, which received intraperitoneal injections of SB290157 (10 mg/kg; cat. no. HY‐101502A/CS‐6852; MedChemExpress) every 48 h (17); and ii) a vehicle group, which received equiva‐ lent volumes of 5% DMSO in sterile saline. ..

    Article Title: C3a/C3aR axis is involved in diabetic kidney injury by regulating podocyte mitophagy in diabetic nephropathy
    Article Snippet: .. Diabetic db/db mice were randomly allocated into two experimental groups (n=6/group): i) A C3aR antagonist (C3aRA)-treated group, which received intraperitoneal injections of SB290157 (10 mg/kg; cat. no. HY-101502A/CS-6852; MedChemExpress) every 48 h ( ); and ii) a vehicle group, which received equivalent volumes of 5% DMSO in sterile saline. ..



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    (A) Representative immunohistochemical staining of C3 and C3aR in each group (scale bar: 25 μm). (B) Immunofluorescence staining showing co-localization of C3 (red) or C3aR (red) with the mesangial cell nuclear marker GATA3 (green); nuclei counterstained with DAPI (blue); yellow signals in merged images indicate co-localization. Insets (4× magnification of boxed regions) display high-resolution details of C3/C3aR staining surrounding GATA3-positive mesangial nuclei, confirming mesangial compartment-specific co-localization. (scale bar: 100 μm (main images); 50 μm (insets)). (C, D) Representative Western blots of C3 and C3aR. (E, F) Quantitative analysis of C3 and C3aR protein expression ( n = 6–8 per group). (G) Serum C3a levels in WT+vehicle ( n = 8), db/db+vehicle ( n = 7), and <t>db/db+C3aRA</t> ( n = 8) groups. Data are expressed as mean ± standard deviation (SD). Statistical analyses were performed using one-way analysis of variance (ANOVA) with Tukey’s post hoc test or unpaired t-test. **** p < 0.0001; *** p < 0.001; ns, not significant.
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    c3a receptor antagonist sb290157 trifluoroacetate  (MedChemExpress)
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    (A) Representative immunohistochemical staining of C3 and C3aR in each group (scale bar: 25 μm). (B) Immunofluorescence staining showing co-localization of C3 (red) or C3aR (red) with the mesangial cell nuclear marker GATA3 (green); nuclei counterstained with DAPI (blue); yellow signals in merged images indicate co-localization. Insets (4× magnification of boxed regions) display high-resolution details of C3/C3aR staining surrounding GATA3-positive mesangial nuclei, confirming mesangial compartment-specific co-localization. (scale bar: 100 μm (main images); 50 μm (insets)). (C, D) Representative Western blots of C3 and C3aR. (E, F) Quantitative analysis of C3 and C3aR protein expression ( n = 6–8 per group). (G) Serum C3a levels in WT+vehicle ( n = 8), db/db+vehicle ( n = 7), and <t>db/db+C3aRA</t> ( n = 8) groups. Data are expressed as mean ± standard deviation (SD). Statistical analyses were performed using one-way analysis of variance (ANOVA) with Tukey’s post hoc test or unpaired t-test. **** p < 0.0001; *** p < 0.001; ns, not significant.
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    (A) Representative immunohistochemical staining of C3 and C3aR in each group (scale bar: 25 μm). (B) Immunofluorescence staining showing co-localization of C3 (red) or C3aR (red) with the mesangial cell nuclear marker GATA3 (green); nuclei counterstained with DAPI (blue); yellow signals in merged images indicate co-localization. Insets (4× magnification of boxed regions) display high-resolution details of C3/C3aR staining surrounding GATA3-positive mesangial nuclei, confirming mesangial compartment-specific co-localization. (scale bar: 100 μm (main images); 50 μm (insets)). (C, D) Representative Western blots of C3 and C3aR. (E, F) Quantitative analysis of C3 and C3aR protein expression ( n = 6–8 per group). (G) Serum C3a levels in WT+vehicle ( n = 8), db/db+vehicle ( n = 7), and <t>db/db+C3aRA</t> ( n = 8) groups. Data are expressed as mean ± standard deviation (SD). Statistical analyses were performed using one-way analysis of variance (ANOVA) with Tukey’s post hoc test or unpaired t-test. **** p < 0.0001; *** p < 0.001; ns, not significant.
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    c3ar specific antagonist trifluoroacetate  (Selleck Chemicals)
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    (A) Representative immunohistochemical staining of C3 and C3aR in each group (scale bar: 25 μm). (B) Immunofluorescence staining showing co-localization of C3 (red) or C3aR (red) with the mesangial cell nuclear marker GATA3 (green); nuclei counterstained with DAPI (blue); yellow signals in merged images indicate co-localization. Insets (4× magnification of boxed regions) display high-resolution details of C3/C3aR staining surrounding GATA3-positive mesangial nuclei, confirming mesangial compartment-specific co-localization. (scale bar: 100 μm (main images); 50 μm (insets)). (C, D) Representative Western blots of C3 and C3aR. (E, F) Quantitative analysis of C3 and C3aR protein expression ( n = 6–8 per group). (G) Serum C3a levels in WT+vehicle ( n = 8), db/db+vehicle ( n = 7), and <t>db/db+C3aRA</t> ( n = 8) groups. Data are expressed as mean ± standard deviation (SD). Statistical analyses were performed using one-way analysis of variance (ANOVA) with Tukey’s post hoc test or unpaired t-test. **** p < 0.0001; *** p < 0.001; ns, not significant.
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    Image Search Results


    (A) Representative immunohistochemical staining of C3 and C3aR in each group (scale bar: 25 μm). (B) Immunofluorescence staining showing co-localization of C3 (red) or C3aR (red) with the mesangial cell nuclear marker GATA3 (green); nuclei counterstained with DAPI (blue); yellow signals in merged images indicate co-localization. Insets (4× magnification of boxed regions) display high-resolution details of C3/C3aR staining surrounding GATA3-positive mesangial nuclei, confirming mesangial compartment-specific co-localization. (scale bar: 100 μm (main images); 50 μm (insets)). (C, D) Representative Western blots of C3 and C3aR. (E, F) Quantitative analysis of C3 and C3aR protein expression ( n = 6–8 per group). (G) Serum C3a levels in WT+vehicle ( n = 8), db/db+vehicle ( n = 7), and db/db+C3aRA ( n = 8) groups. Data are expressed as mean ± standard deviation (SD). Statistical analyses were performed using one-way analysis of variance (ANOVA) with Tukey’s post hoc test or unpaired t-test. **** p < 0.0001; *** p < 0.001; ns, not significant.

    Journal: PeerJ

    Article Title: Pharmacological targeting of C3aR modulates mesangial matrix deposition in db/db mice

    doi: 10.7717/peerj.21248

    Figure Lengend Snippet: (A) Representative immunohistochemical staining of C3 and C3aR in each group (scale bar: 25 μm). (B) Immunofluorescence staining showing co-localization of C3 (red) or C3aR (red) with the mesangial cell nuclear marker GATA3 (green); nuclei counterstained with DAPI (blue); yellow signals in merged images indicate co-localization. Insets (4× magnification of boxed regions) display high-resolution details of C3/C3aR staining surrounding GATA3-positive mesangial nuclei, confirming mesangial compartment-specific co-localization. (scale bar: 100 μm (main images); 50 μm (insets)). (C, D) Representative Western blots of C3 and C3aR. (E, F) Quantitative analysis of C3 and C3aR protein expression ( n = 6–8 per group). (G) Serum C3a levels in WT+vehicle ( n = 8), db/db+vehicle ( n = 7), and db/db+C3aRA ( n = 8) groups. Data are expressed as mean ± standard deviation (SD). Statistical analyses were performed using one-way analysis of variance (ANOVA) with Tukey’s post hoc test or unpaired t-test. **** p < 0.0001; *** p < 0.001; ns, not significant.

    Article Snippet: The C3aRA compound (SB290157 trifluoroacetate; HY-101502A; MedChemExpress, Monmouth Junction, NJ, USA) was dissolved in DMSO and diluted with 40% PEG300, 5% Tween-80, and 53% normal saline to a final concentration of 2 mg/mL.

    Techniques: Immunohistochemical staining, Staining, Immunofluorescence, Marker, Western Blot, Expressing, Standard Deviation