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sb203580 207  (MedChemExpress)


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    Structured Review

    MedChemExpress sb203580 207
    Sb203580 207, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 530 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sb203580/Adezmapimod/pm42612769-76-0-27
    Average 98 stars, based on 530 article reviews
    sb203580 207 - by Bioz Stars, 2026-09
    98/100 stars

    Images

    Related Articles

    Activation Assay:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Western Blot:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Phospho-proteomics:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Infection:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Incubation:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Injection:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    RNA Sequencing:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Reverse Transcription Polymerase Chain Reaction:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Flow Cytometry:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Expressing:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Comparison:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Inhibition:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Control:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    Activity Assay:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).

    MTT Assay:

    Article Title: The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms.
    Article Snippet: Dexmedetomidine (HY-17034), SB203580 (HY-10256), and SC79 (HY-18749) were purchased from MedChemExpress (MCE, USA).



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    TLCA regulates mitochondrial biogenesis and altered myofiber type composition through the <t>p38</t> MAPK/PGC-1α signaling pathway. A Cell viability of cells treated with different concentrations of TLCA for 24 h (n = 10). B & F The mRNA expression of MYH1A and MYH7B (n = 6). C & G Intracellular enzymatic activities of succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH), ATP content and mitochondrial DNA (mtDNA) content (n = 6). D & H The mRNA expression of HK1, GPI, PGAM1, PGK1, PYGL, PGC-1α, NRF1 and TFAM (n = 6). E The protein expression of PGC-1α, <t>p38</t> <t>MAPK</t> and phosphorylation p38 MAPK (n = 3). I The protein expression of PGC-1α (n = 3). Data were shown as mean ± SD; *Represents significant difference when compared with 0 μM TLCA or CON group, and # represents significant difference when compared with TLCA group. *& # P < 0.05, ⁎⁎ & ## P < 0.01, ⁎⁎⁎ & ### P < 0.001.
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    TLCA regulates mitochondrial biogenesis and altered myofiber type composition through the p38 MAPK/PGC-1α signaling pathway. A Cell viability of cells treated with different concentrations of TLCA for 24 h (n = 10). B & F The mRNA expression of MYH1A and MYH7B (n = 6). C & G Intracellular enzymatic activities of succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH), ATP content and mitochondrial DNA (mtDNA) content (n = 6). D & H The mRNA expression of HK1, GPI, PGAM1, PGK1, PYGL, PGC-1α, NRF1 and TFAM (n = 6). E The protein expression of PGC-1α, p38 MAPK and phosphorylation p38 MAPK (n = 3). I The protein expression of PGC-1α (n = 3). Data were shown as mean ± SD; *Represents significant difference when compared with 0 μM TLCA or CON group, and # represents significant difference when compared with TLCA group. *& # P < 0.05, ⁎⁎ & ## P < 0.01, ⁎⁎⁎ & ### P < 0.001.

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    Figure Lengend Snippet: TLCA regulates mitochondrial biogenesis and altered myofiber type composition through the p38 MAPK/PGC-1α signaling pathway. A Cell viability of cells treated with different concentrations of TLCA for 24 h (n = 10). B & F The mRNA expression of MYH1A and MYH7B (n = 6). C & G Intracellular enzymatic activities of succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH), ATP content and mitochondrial DNA (mtDNA) content (n = 6). D & H The mRNA expression of HK1, GPI, PGAM1, PGK1, PYGL, PGC-1α, NRF1 and TFAM (n = 6). E The protein expression of PGC-1α, p38 MAPK and phosphorylation p38 MAPK (n = 3). I The protein expression of PGC-1α (n = 3). Data were shown as mean ± SD; *Represents significant difference when compared with 0 μM TLCA or CON group, and # represents significant difference when compared with TLCA group. *& # P < 0.05, ⁎⁎ & ## P < 0.01, ⁎⁎⁎ & ### P < 0.001.

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    Techniques: Expressing, Phospho-proteomics