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saha  (MedChemExpress)


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    MedChemExpress saha
    XQ2 has synergistic effects with several LRAs on the reactivation of latent HIV-1. J-Lat A2 (A, B) and ACH2 (C, D) cells were stimulated with PMA (10 ng/mL), XQ2 (30 μM), prostratin (0.5 μM), <t>SAHA</t> (0.5 <t>μM),</t> <t>JQ1</t> (0.5 μM), or combinations therein for 48 h. The percentage of GFP-positive cells or p24 antigen was measured by flow cytometry or ELISA, and the corresponding cell viability was examined by MTT assay. The synergy of the LRA combinations was calculated by using the Bliss independence model. Δf axy = 0, Δf axy > 0, and Δf axy < 0 indicate additive, synergistic, and antagonistic effects, respectively. The data represent the means ± SDs of three independent experiments. One-way ANOVA followed by Dunnett’s multiple comparison post hoc test was used to statistically analyze the differences between the XQ2 or prostratin, SAHA, JQ1 alone, and combination groups (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).
    Saha, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 238 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/saha/product/MedChemExpress
    Average 96 stars, based on 238 article reviews
    saha - by Bioz Stars, 2026-03
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    1) Product Images from "XQ2, a Novel Derivative of Resveratrol, Reactivates Latent HIV‑1 via the Activation of Positive Transcription Elongation Factor B"

    Article Title: XQ2, a Novel Derivative of Resveratrol, Reactivates Latent HIV‑1 via the Activation of Positive Transcription Elongation Factor B

    Journal: ACS Omega

    doi: 10.1021/acsomega.5c10420

    XQ2 has synergistic effects with several LRAs on the reactivation of latent HIV-1. J-Lat A2 (A, B) and ACH2 (C, D) cells were stimulated with PMA (10 ng/mL), XQ2 (30 μM), prostratin (0.5 μM), SAHA (0.5 μM), JQ1 (0.5 μM), or combinations therein for 48 h. The percentage of GFP-positive cells or p24 antigen was measured by flow cytometry or ELISA, and the corresponding cell viability was examined by MTT assay. The synergy of the LRA combinations was calculated by using the Bliss independence model. Δf axy = 0, Δf axy > 0, and Δf axy < 0 indicate additive, synergistic, and antagonistic effects, respectively. The data represent the means ± SDs of three independent experiments. One-way ANOVA followed by Dunnett’s multiple comparison post hoc test was used to statistically analyze the differences between the XQ2 or prostratin, SAHA, JQ1 alone, and combination groups (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).
    Figure Legend Snippet: XQ2 has synergistic effects with several LRAs on the reactivation of latent HIV-1. J-Lat A2 (A, B) and ACH2 (C, D) cells were stimulated with PMA (10 ng/mL), XQ2 (30 μM), prostratin (0.5 μM), SAHA (0.5 μM), JQ1 (0.5 μM), or combinations therein for 48 h. The percentage of GFP-positive cells or p24 antigen was measured by flow cytometry or ELISA, and the corresponding cell viability was examined by MTT assay. The synergy of the LRA combinations was calculated by using the Bliss independence model. Δf axy = 0, Δf axy > 0, and Δf axy < 0 indicate additive, synergistic, and antagonistic effects, respectively. The data represent the means ± SDs of three independent experiments. One-way ANOVA followed by Dunnett’s multiple comparison post hoc test was used to statistically analyze the differences between the XQ2 or prostratin, SAHA, JQ1 alone, and combination groups (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).

    Techniques Used: Flow Cytometry, Enzyme-linked Immunosorbent Assay, MTT Assay, Comparison



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    Image Search Results


    XQ2 has synergistic effects with several LRAs on the reactivation of latent HIV-1. J-Lat A2 (A, B) and ACH2 (C, D) cells were stimulated with PMA (10 ng/mL), XQ2 (30 μM), prostratin (0.5 μM), SAHA (0.5 μM), JQ1 (0.5 μM), or combinations therein for 48 h. The percentage of GFP-positive cells or p24 antigen was measured by flow cytometry or ELISA, and the corresponding cell viability was examined by MTT assay. The synergy of the LRA combinations was calculated by using the Bliss independence model. Δf axy = 0, Δf axy > 0, and Δf axy < 0 indicate additive, synergistic, and antagonistic effects, respectively. The data represent the means ± SDs of three independent experiments. One-way ANOVA followed by Dunnett’s multiple comparison post hoc test was used to statistically analyze the differences between the XQ2 or prostratin, SAHA, JQ1 alone, and combination groups (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).

    Journal: ACS Omega

    Article Title: XQ2, a Novel Derivative of Resveratrol, Reactivates Latent HIV‑1 via the Activation of Positive Transcription Elongation Factor B

    doi: 10.1021/acsomega.5c10420

    Figure Lengend Snippet: XQ2 has synergistic effects with several LRAs on the reactivation of latent HIV-1. J-Lat A2 (A, B) and ACH2 (C, D) cells were stimulated with PMA (10 ng/mL), XQ2 (30 μM), prostratin (0.5 μM), SAHA (0.5 μM), JQ1 (0.5 μM), or combinations therein for 48 h. The percentage of GFP-positive cells or p24 antigen was measured by flow cytometry or ELISA, and the corresponding cell viability was examined by MTT assay. The synergy of the LRA combinations was calculated by using the Bliss independence model. Δf axy = 0, Δf axy > 0, and Δf axy < 0 indicate additive, synergistic, and antagonistic effects, respectively. The data represent the means ± SDs of three independent experiments. One-way ANOVA followed by Dunnett’s multiple comparison post hoc test was used to statistically analyze the differences between the XQ2 or prostratin, SAHA, JQ1 alone, and combination groups (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001).

    Article Snippet: Small-molecule inhibitors such as Resveratrol, JQ1, and SAHA were sourced from MedChemExpress (MCE, Vantaa, Finland).

    Techniques: Flow Cytometry, Enzyme-linked Immunosorbent Assay, MTT Assay, Comparison