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small molecule inhibitor rpcamps  (Tocris)


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    Structured Review

    Tocris small molecule inhibitor rpcamps
    Small Molecule Inhibitor Rpcamps, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 35 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rpcamps/cAMPS-Rp%2C+triethylammonium+salt/pmc10153428-277-0-6
    Average 94 stars, based on 35 article reviews
    small molecule inhibitor rpcamps - by Bioz Stars, 2026-09
    94/100 stars

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    Related Articles

    Control:

    Article Title: Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling
    Article Snippet: The following inhibitors were used: KT5720 (PKA; K3761; Sigma-Aldrich), RpcAMPS (PKA; 1337; Tocris Bioscience), ddA (tmACs; 288104; EMD Millipore), KH7 (sAC; 3834; Tocris Bioscience), 2-HE (sAC; 13019; Cayman Chemical), DIDS, anion channel blocker (D3514; Sigma-Aldrich), U0126 (MEK; 662005; EMD Millipore), ESI09 (EPAC1/2; SML0814; Sigma-Aldrich), and Dyngo-4a (dynamin; ab120689; Abcam).

    Article Title: Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Article Snippet: The following small molecule inhibitors were used in neurite outgrowth assays: RpCAMPS (1337/1, Tocris), ESI-09 (4773, Tocris), NSC23766 (2161, Tocris), EHT1864 (3872, Tocris), Y27632 (1254, Tocris), ZCL278 (CAS 587841-73-4, Calbiochem), GW5074 (1381, Tocris), FR180204 (3706, Tocris), LMK235 (4830/10, TOCRIS), Rapamycin (ab120224, Abcam), PLX4720 (ab141362, Abcam), U0126 (1144, Tocris).

    Stable Transfection:

    Article Title: Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling
    Article Snippet: The following inhibitors were used: KT5720 (PKA; K3761; Sigma-Aldrich), RpcAMPS (PKA; 1337; Tocris Bioscience), ddA (tmACs; 288104; EMD Millipore), KH7 (sAC; 3834; Tocris Bioscience), 2-HE (sAC; 13019; Cayman Chemical), DIDS, anion channel blocker (D3514; Sigma-Aldrich), U0126 (MEK; 662005; EMD Millipore), ESI09 (EPAC1/2; SML0814; Sigma-Aldrich), and Dyngo-4a (dynamin; ab120689; Abcam).

    Article Title: Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Article Snippet: The following small molecule inhibitors were used in neurite outgrowth assays: RpCAMPS (1337/1, Tocris), ESI-09 (4773, Tocris), NSC23766 (2161, Tocris), EHT1864 (3872, Tocris), Y27632 (1254, Tocris), ZCL278 (CAS 587841-73-4, Calbiochem), GW5074 (1381, Tocris), FR180204 (3706, Tocris), LMK235 (4830/10, TOCRIS), Rapamycin (ab120224, Abcam), PLX4720 (ab141362, Abcam), U0126 (1144, Tocris).

    Expressing:

    Article Title: Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling
    Article Snippet: The following inhibitors were used: KT5720 (PKA; K3761; Sigma-Aldrich), RpcAMPS (PKA; 1337; Tocris Bioscience), ddA (tmACs; 288104; EMD Millipore), KH7 (sAC; 3834; Tocris Bioscience), 2-HE (sAC; 13019; Cayman Chemical), DIDS, anion channel blocker (D3514; Sigma-Aldrich), U0126 (MEK; 662005; EMD Millipore), ESI09 (EPAC1/2; SML0814; Sigma-Aldrich), and Dyngo-4a (dynamin; ab120689; Abcam).

    Article Title: Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Article Snippet: The following small molecule inhibitors were used in neurite outgrowth assays: RpCAMPS (1337/1, Tocris), ESI-09 (4773, Tocris), NSC23766 (2161, Tocris), EHT1864 (3872, Tocris), Y27632 (1254, Tocris), ZCL278 (CAS 587841-73-4, Calbiochem), GW5074 (1381, Tocris), FR180204 (3706, Tocris), LMK235 (4830/10, TOCRIS), Rapamycin (ab120224, Abcam), PLX4720 (ab141362, Abcam), U0126 (1144, Tocris).

    Transfection:

    Article Title: Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling
    Article Snippet: The following inhibitors were used: KT5720 (PKA; K3761; Sigma-Aldrich), RpcAMPS (PKA; 1337; Tocris Bioscience), ddA (tmACs; 288104; EMD Millipore), KH7 (sAC; 3834; Tocris Bioscience), 2-HE (sAC; 13019; Cayman Chemical), DIDS, anion channel blocker (D3514; Sigma-Aldrich), U0126 (MEK; 662005; EMD Millipore), ESI09 (EPAC1/2; SML0814; Sigma-Aldrich), and Dyngo-4a (dynamin; ab120689; Abcam).

    Article Title: Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Article Snippet: The following small molecule inhibitors were used in neurite outgrowth assays: RpCAMPS (1337/1, Tocris), ESI-09 (4773, Tocris), NSC23766 (2161, Tocris), EHT1864 (3872, Tocris), Y27632 (1254, Tocris), ZCL278 (CAS 587841-73-4, Calbiochem), GW5074 (1381, Tocris), FR180204 (3706, Tocris), LMK235 (4830/10, TOCRIS), Rapamycin (ab120224, Abcam), PLX4720 (ab141362, Abcam), U0126 (1144, Tocris).

    Knockdown:

    Article Title: Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling
    Article Snippet: The following inhibitors were used: KT5720 (PKA; K3761; Sigma-Aldrich), RpcAMPS (PKA; 1337; Tocris Bioscience), ddA (tmACs; 288104; EMD Millipore), KH7 (sAC; 3834; Tocris Bioscience), 2-HE (sAC; 13019; Cayman Chemical), DIDS, anion channel blocker (D3514; Sigma-Aldrich), U0126 (MEK; 662005; EMD Millipore), ESI09 (EPAC1/2; SML0814; Sigma-Aldrich), and Dyngo-4a (dynamin; ab120689; Abcam).

    Article Title: Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Article Snippet: The following small molecule inhibitors were used in neurite outgrowth assays: RpCAMPS (1337/1, Tocris), ESI-09 (4773, Tocris), NSC23766 (2161, Tocris), EHT1864 (3872, Tocris), Y27632 (1254, Tocris), ZCL278 (CAS 587841-73-4, Calbiochem), GW5074 (1381, Tocris), FR180204 (3706, Tocris), LMK235 (4830/10, TOCRIS), Rapamycin (ab120224, Abcam), PLX4720 (ab141362, Abcam), U0126 (1144, Tocris).

    Quantitative RT-PCR:

    Article Title: Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling
    Article Snippet: The following inhibitors were used: KT5720 (PKA; K3761; Sigma-Aldrich), RpcAMPS (PKA; 1337; Tocris Bioscience), ddA (tmACs; 288104; EMD Millipore), KH7 (sAC; 3834; Tocris Bioscience), 2-HE (sAC; 13019; Cayman Chemical), DIDS, anion channel blocker (D3514; Sigma-Aldrich), U0126 (MEK; 662005; EMD Millipore), ESI09 (EPAC1/2; SML0814; Sigma-Aldrich), and Dyngo-4a (dynamin; ab120689; Abcam).

    Article Title: Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Article Snippet: The following small molecule inhibitors were used in neurite outgrowth assays: RpCAMPS (1337/1, Tocris), ESI-09 (4773, Tocris), NSC23766 (2161, Tocris), EHT1864 (3872, Tocris), Y27632 (1254, Tocris), ZCL278 (CAS 587841-73-4, Calbiochem), GW5074 (1381, Tocris), FR180204 (3706, Tocris), LMK235 (4830/10, TOCRIS), Rapamycin (ab120224, Abcam), PLX4720 (ab141362, Abcam), U0126 (1144, Tocris).

    Dominant Negative Mutation:

    Article Title: Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling
    Article Snippet: The following inhibitors were used: KT5720 (PKA; K3761; Sigma-Aldrich), RpcAMPS (PKA; 1337; Tocris Bioscience), ddA (tmACs; 288104; EMD Millipore), KH7 (sAC; 3834; Tocris Bioscience), 2-HE (sAC; 13019; Cayman Chemical), DIDS, anion channel blocker (D3514; Sigma-Aldrich), U0126 (MEK; 662005; EMD Millipore), ESI09 (EPAC1/2; SML0814; Sigma-Aldrich), and Dyngo-4a (dynamin; ab120689; Abcam).

    Article Title: Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth.
    Article Snippet: The following small molecule inhibitors were used in neurite outgrowth assays: RpCAMPS (1337/1, Tocris), ESI-09 (4773, Tocris), NSC23766 (2161, Tocris), EHT1864 (3872, Tocris), Y27632 (1254, Tocris), ZCL278 (CAS 587841-73-4, Calbiochem), GW5074 (1381, Tocris), FR180204 (3706, Tocris), LMK235 (4830/10, TOCRIS), Rapamycin (ab120224, Abcam), PLX4720 (ab141362, Abcam), U0126 (1144, Tocris).



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    PKA inhibition with RPcAMP or H89 largely restores the suppressed KCa-sAHP and IsAHP in chronic-phase post-SE neurons. Aa, b, Representative recordings of a KCa-sAHP evoked by a Ca2+ spike (shown in inset; a) and an IsAHP evoked by a depolarizing pulse (b) in a non-SE neuron. B, Same as in A, but recordings were made in a post-SE neuron. C, Same as in A, but recordings were made in non-SE slices treated for >1 h with the PKA inhibitor RPcAMP (100 μm). D, Same as in B, but recordings were made in post-SE slices treated for >1 h with the PKA inhibitor RPcAMP. E, Same as in C, but recordings were made in non-SE slices treated for >1 h with the PKA inhibitor H89 (10 μm). F, Same as in D, but recordings were made in post-SE slices treated for >1 h with the PKA inhibitor H89. Note that in this condition the KCa-sAHP and IsAHP in the non-SE and post-SE neurons appear similar in size. G, Summary bar diagram of KCa-sAHP amplitudes (measured at the peak of the sAHP) in non-SE and post-SE neurons recorded in normal aCSF and in RPcAMP or H89-containing aCSF. H, Summary bar diagram of IsAHP amplitudes (measured at peak current) in non-SE and post-SE neurons recorded in normal aCSF and RPcAMP or H89 containing aCSF. Note that both KCa-sAHP and IsAHP values are markedly and significantly reduced in post-SE neurons, and are largely restored by treating slices with PKA inhibitors (RPcAMP or H89). I, Spikes were evoked by a series of 1-s-long depolarizing current pulses in non-SE and post-SE neurons, all treated with H89. The two plots depict the number of spikes versus stimulus intensity in the two groups of neurons. Although post-SE neurons fire more spikes, the difference between the two plots is not significant, indicating that H89 treatment reduces the excitability of post-SE neurons to near the non-SE level. ***p ≤ 0.001. n.s., Not significant.

    Journal: The Journal of Neuroscience

    Article Title: Protein Kinase A-Mediated Suppression of the Slow Afterhyperpolarizing KCa3.1 Current in Temporal Lobe Epilepsy

    doi: 10.1523/JNEUROSCI.1603-19.2019

    Figure Lengend Snippet: PKA inhibition with RPcAMP or H89 largely restores the suppressed KCa-sAHP and IsAHP in chronic-phase post-SE neurons. Aa, b, Representative recordings of a KCa-sAHP evoked by a Ca2+ spike (shown in inset; a) and an IsAHP evoked by a depolarizing pulse (b) in a non-SE neuron. B, Same as in A, but recordings were made in a post-SE neuron. C, Same as in A, but recordings were made in non-SE slices treated for >1 h with the PKA inhibitor RPcAMP (100 μm). D, Same as in B, but recordings were made in post-SE slices treated for >1 h with the PKA inhibitor RPcAMP. E, Same as in C, but recordings were made in non-SE slices treated for >1 h with the PKA inhibitor H89 (10 μm). F, Same as in D, but recordings were made in post-SE slices treated for >1 h with the PKA inhibitor H89. Note that in this condition the KCa-sAHP and IsAHP in the non-SE and post-SE neurons appear similar in size. G, Summary bar diagram of KCa-sAHP amplitudes (measured at the peak of the sAHP) in non-SE and post-SE neurons recorded in normal aCSF and in RPcAMP or H89-containing aCSF. H, Summary bar diagram of IsAHP amplitudes (measured at peak current) in non-SE and post-SE neurons recorded in normal aCSF and RPcAMP or H89 containing aCSF. Note that both KCa-sAHP and IsAHP values are markedly and significantly reduced in post-SE neurons, and are largely restored by treating slices with PKA inhibitors (RPcAMP or H89). I, Spikes were evoked by a series of 1-s-long depolarizing current pulses in non-SE and post-SE neurons, all treated with H89. The two plots depict the number of spikes versus stimulus intensity in the two groups of neurons. Although post-SE neurons fire more spikes, the difference between the two plots is not significant, indicating that H89 treatment reduces the excitability of post-SE neurons to near the non-SE level. ***p ≤ 0.001. n.s., Not significant.

    Article Snippet: To that end, we treated chronic-phase slices with the cell-permeable PKA inhibitor RPcAMP ( Dostmann et al., 1990 ; Wang et al., 1991 ).

    Techniques: Inhibition