rif  (TargetMol)

Journal: Scientific Reports

Article Title: Repurposing antibacterial drugs identifies ridinilazole and CRS3123 as promising candidates against vancomycin-resistant enterococci

doi: 10.1038/s41598-025-29583-1

Figure Lengend Snippet: Multistep resistance selection of ridinilazole, CRS3123, and rifampicin against Enterococcus species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin. The MICs of each compound were determined daily using the broth microdilution method.

Article Snippet: Fig. 6 Multistep resistance selection of ridinilazole, CRS3123, and rifampicin against Enterococcus species. (A) E. faecalis ATCC 29,212 and (B) E. faecium NR-31,909 were serially passaged over a 10-day period in the presence of ridinilazole, CRS3123, or rifampicin.

Techniques: Selection

Journal: Molecular Plant Pathology

Article Title: Antimicrobial Peptides as Part of the Arsenal of Constitutive and Inducible Seed Defences in Tomato Seed Exudates Against Pathogens

doi: 10.1111/mpp.70164

Figure Lengend Snippet: Effect of exudates from osmoprimed tomato seeds on the growth of plant pathogens in liquid culture. (A) Matrix representing the plant pathogens selected for this study. (B) Heatmap showing the microbial growth in presence of the seed exudates from different genotypes and the priming agents. Numbers represent the percentage of the total area under the curve (AUC) compared to the control without exudates, which is used as a proxy for fungal growth. Aa, Alternaria alternata ; Ab, Alternaria brassicicola ; Cm, Clavibacter michiganensis subsp. michiganensis ; Xc, Xanthomonas campestris pv. campestris . Blue letters indicate fungi and red letters indicate bacteria. Asterisks indicate that the condition resulted in a significant decrease of microbial growth compared to control without exudates. (C) Histograms representing growth inhibition of A. brassicicola (strain Abra43) in presence of exudates from methyl jasmonate (MeJA)‐primed seeds. Values are expressed as percentages of the total AUC compared to the untreated control. Ct, mock‐primed seeds; MeJA, MeJA 2 mM‐primed seeds. Asterisks indicate significant differences according to Student's t test (*** p < 0.001). Error bars represent SD. (D) Curves showing the growth of A. brassicicola (strain Abra43) in presence of exudates from MeJA‐primed seeds. y ‐axis: Absorbance values in arbitrary units; x ‐axis: Time in hours. Data were analysed and plotted with the Mars Omega software (v. 3.42, BMG LabTech). Error bars represent SD.

Article Snippet: Clavibacter michiganensis subsp. michiganensis (Cmm) rifampicin‐resistant strain Cm 144 (CFBP 7572) was maintained on yeast extract‐dextrose‐CaCO 3 (YDC) plates at 25°C, while Xanthomonas campestris pv. campestris (Xcc) rifampicin‐resistant strain ATCC 33913 (Darrasse et al. ) was maintained on tryptic soy agar (TSA) plates at 28°C.

Techniques: Control, Bacteria, Inhibition, Software