r848 (MedChemExpress)
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MedChemExpress
r848
R848, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 126 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/r848/Resiquimod/pm40528637-58-18-27
Average 96 stars, based on 126 article reviews
R848, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 126 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/r848/Resiquimod/pm40528637-58-18-27
Average 96 stars, based on 126 article reviews
r848 - by Bioz Stars,
2026-09
96/100 stars
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Control:Article Title: Ginsenoside Compound K Mitigates Mitochondrial Fission Through Bile Acid Receptors/YAP Signaling to Counteract Podocyte Injury in Lupus Nephritis. Article Snippet: Irreversible renal damage in lupus nephritis (LN) results from critical podocyte injury.. Disruption in the actin cytoskeleton initiates mitochondrial fission to exacerbate podocyte injury.. While ginsenoside compound K (CK) alleviates podocyte injury in lupusprone mice, its mechanism in regulating mitochondrial dynamics underlying remains elusive. Cell Culture:Article Title: Ectopic B lymphocyte follicles exacerbate ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling Article Snippet: .. The sorted B cells were cultured in RPMI-1640 cell culture medium added with anti-CD40 antibody (BioXCell, Cat#BE0016-2, 10 μg/mL), anti-IgM antibody (Biolegend, Cat#157102, 10 μg/mL) and Activation Assay:Article Title: Triptolide derivative STP1 ameliorates murine systemic lupus erythematosus via targeting Fyn kinase. Article Snippet: Triptolide has demonstrated potent immunosuppressive properties in multiple autoimmune disorders, but its severe toxicity has greatly hampered clinical application.. Here, we synthesized a triptolide derivative STP1, which exhibits remarkably reduced toxicity compared with triptolide.. Immune dysfunction plays a critical role in systemic lupus erythematosus (SLE), an archetypical and refractory autoimmune disorder with limited therapeutic options and suboptimal outcomes. Protein-Protein interactions:Article Title: Triptolide derivative STP1 ameliorates murine systemic lupus erythematosus via targeting Fyn kinase. Article Snippet: Triptolide has demonstrated potent immunosuppressive properties in multiple autoimmune disorders, but its severe toxicity has greatly hampered clinical application.. Here, we synthesized a triptolide derivative STP1, which exhibits remarkably reduced toxicity compared with triptolide.. Immune dysfunction plays a critical role in systemic lupus erythematosus (SLE), an archetypical and refractory autoimmune disorder with limited therapeutic options and suboptimal outcomes. CCK-8 Assay:Article Title: Conjugated polymer intrachain donor-acceptor reconfiguration-tailored off-on NIR-II photoacoustic probes with ultralow background for high-fidelity imaging of immunotherapy-associated macrophage reprogramming. Article Snippet: High-fidelity imaging of pro-tumorigenic M2 macrophages reprogramming into anti-tumorigenic M1 phenotypes during tumor immunotherapy is crucial for guiding personalized treatment.. Off-on probes, switching from low “off” state signals to high “on” signals upon biomarker activation, enable visualization of this process.. However, most existing off-on probes fail to deliver high-fidelity imaging, as even low “off” state probe signals are amplified by extensive intratumoral accumulation without biomarker activation, producing a high probe background that is indistinguishable from biomarker-triggered signals and prone to false-positive diagnoses. |