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qnz  (MedChemExpress)


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    MedChemExpress qnz
    Qnz, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 54 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/qnz/product/MedChemExpress
    Average 94 stars, based on 54 article reviews
    qnz - by Bioz Stars, 2026-03
    94/100 stars

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    QNZ inhibits the MMT process by blocking the TNF-α/NF-κB pathway. A - H . Western blot analysis showed that TROP2-overexpressing EVs significantly altered the protein levels of E-cadherin, N-cadherin, vimentin, p-NF-κB p65, TNF-α, and TROP2 in HMrSV5 cells, which were reversed by QNZ (100 nM) treatment. I - J . Effects of TROP2-overexpressing EVs on migration in HMrSV5 cells with or without QNZ (100 nM) treatment. K - M . Effects of TROP2-overexpressing EVs on adhesion of ovarian cancer cells to HMrSV5 cells with or without QNZ (100 nM) treatment. Data are representative of at least three independent experiments and are presented as mean ± SD. ** P < 0.01, *** P < 0.001

    Journal: Journal of Ovarian Research

    Article Title: Trophoblast cell surface antigen 2 (TROP2) from ascitic extracellular vesicles drives peritoneal metastasis of ovarian cancer by mesothelial-to-mesenchymal transition

    doi: 10.1186/s13048-025-01845-6

    Figure Lengend Snippet: QNZ inhibits the MMT process by blocking the TNF-α/NF-κB pathway. A - H . Western blot analysis showed that TROP2-overexpressing EVs significantly altered the protein levels of E-cadherin, N-cadherin, vimentin, p-NF-κB p65, TNF-α, and TROP2 in HMrSV5 cells, which were reversed by QNZ (100 nM) treatment. I - J . Effects of TROP2-overexpressing EVs on migration in HMrSV5 cells with or without QNZ (100 nM) treatment. K - M . Effects of TROP2-overexpressing EVs on adhesion of ovarian cancer cells to HMrSV5 cells with or without QNZ (100 nM) treatment. Data are representative of at least three independent experiments and are presented as mean ± SD. ** P < 0.01, *** P < 0.001

    Article Snippet: D-Luciferin potassium salt was obtained from Yeasen (China), recombinant human TGF-β1 and human IL-1β were from R&D Systems (USA), and quinazoline (QNZ) was purchased from MCE (USA).

    Techniques: Blocking Assay, Western Blot, Migration