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puma ab9643 abcam  (Proteintech)


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    Proteintech puma ab9643 abcam
    Puma Ab9643 Abcam, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 76 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/puma ab9643 abcam/product/Proteintech
    Average 94 stars, based on 76 article reviews
    puma ab9643 abcam - by Bioz Stars, 2026-04
    94/100 stars

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    TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression of p21 and PUMA induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.

    Journal: Translational Cancer Research

    Article Title: TC2N promotes the proliferation and invasion of head and neck cancer cells with the p53-R175H

    doi: 10.21037/tcr-24-2130

    Figure Lengend Snippet: TC2N activates p53-R175H-mediated pro-cancer signals. (A) TC2N augmented pro-cancer signals regulated by p53-R175H. (B) TC2N upregulated p53-R248 protein expression. (C) Interference with p53-R175H counteracted the changes in the phosphorylation of Met and the expression of p21 and PUMA induced by TC2N overexpression. (D) Schematic diagram of TC2N promoting HNSCC growth and invasion through p53-R175H. HNSCC, head and neck squamous cell carcinoma; NC, negative control; PUMA, p53 upregulated modulator of apoptosis; TC2N, tandem C2 domains, nuclear.

    Article Snippet: The primary antibody against TC2N (Cat. #: HPA027549) was obtained from Sigma-Aldrich; c-Met (Cat. #: 25869-1-AP), phospho-c-Met (Cat. #: 30737-1-AP), p21 (Cat. #: 10355-1-AP), PUMA (Cat. #: 55120-1-AP), p53 (Cat. #: 10442-1-AP) and Actin (Cat. #: 66009-1-Ig) were purchased from Proteintech Group (Wuhan, China); secondary antibodies (Cat. #: A0216 and A0208) were obtained from Beyotime.

    Techniques: Expressing, Phospho-proteomics, Over Expression, Negative Control