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psb0788  (Tocris)


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    Tocris psb0788
    Figure 5. <t>PSB0788</t> treatment increased MBP expression. (a) Intraperitoneal injection of PSB0788 at E19 was performed to observe changes in oligodendrocytes at all stages in brains of offspring rats at P7. (b) Immunohistochemical results showed that the number of MBP positive cells in the shoulder of the corpus callosum in the PVL-PSB group was significantly increased compared to the PVL-CON group.Scale bar.100 μm. (c) The results of western blot showed that the level of MBP protein in the cerebral white matter of offspring rats in the PVL-PSB group was increased significantly. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.
    Psb0788, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/psb0788/pm35436416-45-22-23?v=Tocris
    Average 90 stars, based on 5 article reviews
    psb0788 - by Bioz Stars, 2026-07
    90/100 stars

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    1) Product Images from "PSB0788 ameliorates maternal inflammation-induced periventricular leukomalacia-like injury."

    Article Title: PSB0788 ameliorates maternal inflammation-induced periventricular leukomalacia-like injury.

    Journal: Bioengineered

    doi: 10.1080/21655979.2022.2061296

    Figure 5. PSB0788 treatment increased MBP expression. (a) Intraperitoneal injection of PSB0788 at E19 was performed to observe changes in oligodendrocytes at all stages in brains of offspring rats at P7. (b) Immunohistochemical results showed that the number of MBP positive cells in the shoulder of the corpus callosum in the PVL-PSB group was significantly increased compared to the PVL-CON group.Scale bar.100 μm. (c) The results of western blot showed that the level of MBP protein in the cerebral white matter of offspring rats in the PVL-PSB group was increased significantly. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.
    Figure Legend Snippet: Figure 5. PSB0788 treatment increased MBP expression. (a) Intraperitoneal injection of PSB0788 at E19 was performed to observe changes in oligodendrocytes at all stages in brains of offspring rats at P7. (b) Immunohistochemical results showed that the number of MBP positive cells in the shoulder of the corpus callosum in the PVL-PSB group was significantly increased compared to the PVL-CON group.Scale bar.100 μm. (c) The results of western blot showed that the level of MBP protein in the cerebral white matter of offspring rats in the PVL-PSB group was increased significantly. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.

    Techniques Used: Expressing, Injection, Immunohistochemical staining, Western Blot

    Figure 6. PSB0788 treatment of PVL promoted the development and differentiation of OPCs. (a) The number of NG2 positive cells in the shoulder of the corpus callosum in the PVL-PSB group was higher than in the PVL-CON group. Scale bar.20 μm.(b) NG2 protein level increased in the cerebral white matter of offspring rats in the PVL-PSB group. (c) The number of CC-1/Olig2 positive cells in the shoulder of the corpus callosum increased in the PVL-PSB group. Scale bar.100 μm.(d) Oligodendrocytes in the PVL-PSB group tended to be normal.Scale bar.2 μm. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.
    Figure Legend Snippet: Figure 6. PSB0788 treatment of PVL promoted the development and differentiation of OPCs. (a) The number of NG2 positive cells in the shoulder of the corpus callosum in the PVL-PSB group was higher than in the PVL-CON group. Scale bar.20 μm.(b) NG2 protein level increased in the cerebral white matter of offspring rats in the PVL-PSB group. (c) The number of CC-1/Olig2 positive cells in the shoulder of the corpus callosum increased in the PVL-PSB group. Scale bar.100 μm.(d) Oligodendrocytes in the PVL-PSB group tended to be normal.Scale bar.2 μm. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.

    Techniques Used:

    Figure 7. PSB0788 treatment activated anti-inflammatory microglia. (a) The level of inflammatory cytokines IL-1 β, IL-6 and TNF-α were not significantly different in the PVL-PSB group from those in the PVL-CON group, while IL-10 was significantly increased in the PVL-PSB group. #P < 0.05 for student’s t-test.
    Figure Legend Snippet: Figure 7. PSB0788 treatment activated anti-inflammatory microglia. (a) The level of inflammatory cytokines IL-1 β, IL-6 and TNF-α were not significantly different in the PVL-PSB group from those in the PVL-CON group, while IL-10 was significantly increased in the PVL-PSB group. #P < 0.05 for student’s t-test.

    Techniques Used:



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    Figure 5. <t>PSB0788</t> treatment increased MBP expression. (a) Intraperitoneal injection of PSB0788 at E19 was performed to observe changes in oligodendrocytes at all stages in brains of offspring rats at P7. (b) Immunohistochemical results showed that the number of MBP positive cells in the shoulder of the corpus callosum in the PVL-PSB group was significantly increased compared to the PVL-CON group.Scale bar.100 μm. (c) The results of western blot showed that the level of MBP protein in the cerebral white matter of offspring rats in the PVL-PSB group was increased significantly. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.
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    Figure 5. PSB0788 treatment increased MBP expression. (a) Intraperitoneal injection of PSB0788 at E19 was performed to observe changes in oligodendrocytes at all stages in brains of offspring rats at P7. (b) Immunohistochemical results showed that the number of MBP positive cells in the shoulder of the corpus callosum in the PVL-PSB group was significantly increased compared to the PVL-CON group.Scale bar.100 μm. (c) The results of western blot showed that the level of MBP protein in the cerebral white matter of offspring rats in the PVL-PSB group was increased significantly. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.

    Journal: Bioengineered

    Article Title: PSB0788 ameliorates maternal inflammation-induced periventricular leukomalacia-like injury.

    doi: 10.1080/21655979.2022.2061296

    Figure Lengend Snippet: Figure 5. PSB0788 treatment increased MBP expression. (a) Intraperitoneal injection of PSB0788 at E19 was performed to observe changes in oligodendrocytes at all stages in brains of offspring rats at P7. (b) Immunohistochemical results showed that the number of MBP positive cells in the shoulder of the corpus callosum in the PVL-PSB group was significantly increased compared to the PVL-CON group.Scale bar.100 μm. (c) The results of western blot showed that the level of MBP protein in the cerebral white matter of offspring rats in the PVL-PSB group was increased significantly. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.

    Article Snippet: SD rats in the selective A2BAR antagonist group (PVL-PSB group) were intraperitoneally injected with LPS on E17 and E18, and 10 μg/kg PSB0788 (Tocris Bioscience) on E19.

    Techniques: Expressing, Injection, Immunohistochemical staining, Western Blot

    Figure 6. PSB0788 treatment of PVL promoted the development and differentiation of OPCs. (a) The number of NG2 positive cells in the shoulder of the corpus callosum in the PVL-PSB group was higher than in the PVL-CON group. Scale bar.20 μm.(b) NG2 protein level increased in the cerebral white matter of offspring rats in the PVL-PSB group. (c) The number of CC-1/Olig2 positive cells in the shoulder of the corpus callosum increased in the PVL-PSB group. Scale bar.100 μm.(d) Oligodendrocytes in the PVL-PSB group tended to be normal.Scale bar.2 μm. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.

    Journal: Bioengineered

    Article Title: PSB0788 ameliorates maternal inflammation-induced periventricular leukomalacia-like injury.

    doi: 10.1080/21655979.2022.2061296

    Figure Lengend Snippet: Figure 6. PSB0788 treatment of PVL promoted the development and differentiation of OPCs. (a) The number of NG2 positive cells in the shoulder of the corpus callosum in the PVL-PSB group was higher than in the PVL-CON group. Scale bar.20 μm.(b) NG2 protein level increased in the cerebral white matter of offspring rats in the PVL-PSB group. (c) The number of CC-1/Olig2 positive cells in the shoulder of the corpus callosum increased in the PVL-PSB group. Scale bar.100 μm.(d) Oligodendrocytes in the PVL-PSB group tended to be normal.Scale bar.2 μm. Data were expressed as mean ±SD (n = 5). #P < 0.05 for student’s t-test.

    Article Snippet: SD rats in the selective A2BAR antagonist group (PVL-PSB group) were intraperitoneally injected with LPS on E17 and E18, and 10 μg/kg PSB0788 (Tocris Bioscience) on E19.

    Techniques:

    Figure 7. PSB0788 treatment activated anti-inflammatory microglia. (a) The level of inflammatory cytokines IL-1 β, IL-6 and TNF-α were not significantly different in the PVL-PSB group from those in the PVL-CON group, while IL-10 was significantly increased in the PVL-PSB group. #P < 0.05 for student’s t-test.

    Journal: Bioengineered

    Article Title: PSB0788 ameliorates maternal inflammation-induced periventricular leukomalacia-like injury.

    doi: 10.1080/21655979.2022.2061296

    Figure Lengend Snippet: Figure 7. PSB0788 treatment activated anti-inflammatory microglia. (a) The level of inflammatory cytokines IL-1 β, IL-6 and TNF-α were not significantly different in the PVL-PSB group from those in the PVL-CON group, while IL-10 was significantly increased in the PVL-PSB group. #P < 0.05 for student’s t-test.

    Article Snippet: SD rats in the selective A2BAR antagonist group (PVL-PSB group) were intraperitoneally injected with LPS on E17 and E18, and 10 μg/kg PSB0788 (Tocris Bioscience) on E19.

    Techniques: