Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Article Title: Non-Lactobacillus-Dominant and Polymicrobial Vaginal Microbiomes Are More Common in Younger South African Women and Predictive of Increased Risk of Human Immunodeficiency Virus Acquisition.
doi: 10.1093/cid/ciac938
Figure Lengend Snippet: Figure 2. Vaginal bacterial metaproteome profiles of study participants stratified by age group. A, Proportions of bacterial taxa and functional pathways are displayed for each age group: 18–19 (n = 93), 20–24 (n = 326), and 25–41 (n = 269) years. Stacked bar plots are annotated with Lactobacillus dominance status and community state type (CST) categorization. B, Proportion of Lactobacillus-/non-Lactobacillus-dominant status between age groups were assessed for statistical significance using Fisher exact test. C, Proportions of CST-polymicrobial relative to CST–Lactobacillus crispatus dominant between age groups were assessed for statistical significance using Fisher exact test. Abbreviations: CST, community state type; GV, Gardnerella vaginalis dominant; LC, Lactobacillus crispatus dominant; LD, Lactobacillus dominant; LI, Lactobacillus iners dom inant; LS, Lactobacillus species dominant; nLD, non-Lactobacillus dominant; OR, odds ratio; PM, polymicrobial.
Article Snippet: Four microbiome types were identified based on predominant taxa, including Lactobacillus crispatus (CST-LC, 12.2%), Lactobacillus iners (CST-LI, 43.6%), Gardnerella vaginalis (CST-GV, 26.6%), or polymicrobial (CST-PM, 15.1%).
Techniques: Functional Assay